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HEMOSTAZ Yard. Doç. Dr. Murat ÖRMEN
SUNUM PLANI n Hemostaza genel bakış n Hemostatik sistemlerin bileşenleri n Primer hemostaz n Sekonder hemostaz
n Hemotaz, kanama,tromboz animasyon
Coagulation Factors n Fibrinogen Group n Factors I, V, VIII and XIII n Prothrombin Group n Factors II, VII, IX and X n Contact Group n Factors XI, XII n Prekallikrein (Fletcher Factor) n High Molecular Weight Kininogen n (Fitzgerald Factor)
Thrombolytic Therapy t-PA Streptokinase Urokinase Anaphylaxis GI Bleeding Intracranial Hemorrhage
Anatomy of a Platelet Dense Body ADPSerotonin ATPCalcium Microtubular System Glycogen Exterior Coat (Glycocalyx) Mitochondria Surface Connecting System Cytosol Factor XIII Alpha Granules PF 4 Fibrinogen Factor VFibronectin Factor VIII R:ag Thromboglobulin (vWF) Plasma Membrane PF 3 Dense Tubular System
Platelet Function Aggregation Coagulation Shape Change Release Fibrin Formation A B C 3 seconds 10 seconds 5 minutes ADP Release Adhesion
Clot Formation Review with Animations Nicole L. Draper, MD.
1. What is the sequence of the intrinsic pathway of coagulation?
Hemostasis and blood coagulation Lecture by Dr Sandeep :30-10:30 am.
HEMOSTAZ Yard. Doç. Dr. Murat ÖRMEN. Vessels Platelets Fibrinolysis/Inhibitors Coagulation Proteins BleedingClotting Hemostaz.
Coagulation Mechanisms TEXTBOOK OF MEDICAL PHYSIOLOGY GUYTON & HALL 11 TH EDITION UNIT VI CHAPTER 3 6 Dr Mohammed Alotaibi MRes, PhD (Liverpool, England)
Blood coagulation involves a biological amplification system in which relatively few initiation substances sequentially activate by proteolysis a cascade.
거핵구 (Megakaryocytic). Thrombocyte(Platelets ) Platelet Satelitism ( 혈소판 위성현상 ) EDTA Pseudothrombocytopenia.
CHAPTER13 Biomaterials and Thrombosis 13-1 Introduction: Overview of Hemostasis Blood-Biomaterials Interaction via protein coats ---- blood coagulation.
Basic Principles of Hemostasis Basic Principles of Hemostasis 1.
Drmsaiem HEMOSTASIS Damaged Blood Vessels. On vessel injury Vasoconstriction occurs as a neurogenic response. Injury breaks the smooth endothelial lining,
Hemostasis: Dr.Faten Hemostasis: Hemo/Stasis Hemo=BleedigStasis=Stop.
HEAMOSTASIS & FIBRINOLYSIS 1 HAEMOSTASIS & FIBRINOLYSIS DR B L Mtinangi DEPARTMENT OF PHYSIOLOGY Hubert Kairuki Memorial University December 3, 2015.
Coagulation Just the basics.... Three steps Vasoconstriction Platelet plug formation Fibrin clot formation.
Anticoagulants, Thrombolytic Agents and Antiplatelet Drugs Management and Prevention of Vascular Thrombosis Benedict R. Lucchesi, M.D., Ph.D. Department.
Tabuk University Faculty of Applied Medical Sciences Department Of Medical Lab. Technology 3 rd Year – Level 5 – AY
HEMOSTASIS. Due to damaged blood vessels Events that stop bleeding.
1 Functional Aspects of. 2 Homeostasis: State of fluid equilibrium within the blood vessels Vessels Platelets Fibrinolysis/Inhibitors Coagulation Proteins.
HEMOSTASIS. Hemostasis a body mechanism to stop traumatic bleeding to prevent spontaneous bleeding to keep the fluidity of blood.
BLOOD AND BODY DEFENCE Dr. Amel Eassawi Dr. Abdelrahman Mustafa 1.
Coagulation Mechanisms Dr. Nervana Bayoumy Associate Professor Department of Physiology.
ПОРТФОЛИО профессиональной деятельности Белово 2015 Таюшовой Натальи Борисовны Преподавателя дисциплин «Химия», «Биология»
Haemostasis TEXTBOOK OF MEDICAL PHYSIOLOGY GUYTON & HALL 11 TH EDITION UNIT VI CHAPTER 3 6 Dr.Salah Elmalik Department of Physiology College of Medicine.
Mechanism of Haemostasis & Coagulation DR. Khaled Khalil.
Hemostasis and Blood Coagulation Events in Hemostasis The term hemostasis means prevention of blood loss. Whenever a vessel is severed or ruptured, hemostasis.
HEMOSTASIS Hemostasis The process by which the body stops bleeding upon injury and maintains blood in the fluid state in the vascular compartment Process.
Blood Course 2nd Year Physiotherapy- November Lecture 3 HAEMOSTASIS I.
Objectives At the end of this lecture student should be able to: 1.Recognize different stages of hemostasis 2.Describe formation and development.
MLAB 1227: C OAGULATION K ERI B ROPHY -M ARTINEZ The Platelets.
Nerves Smooth muscle Endothelium Platelets White cells eg neutrophils Red cells.
Coagulation (the basics) and recombinant Factor VIIa Mechanism of Action Jerrold H. Levy, MD Emory University School of Medicine and Emory Healthcare Atlanta,
PLATELET AND HEMOSTASIS Dr. Zahoor Lecture - 6 HMIM BLOCK
HEMOSTASIS Primary hemostasis. HEMOSTASIS Hemostasis The process by which the body stops bleeding upon injury and maintains blood in the fluid state in.
Platelet Structure & Function Dr. Nervana Bayoumy MD, PhD (Aberdeen – UK)) Associate Professor of Physiology, College of Medicine.
Coagulation Or Clotting of Blood
Haemostasis Prof. K. Sivapalan. June 2013Haemostasis2 Thrombocytes 2 – 4 μm in diameter. Half life – 4 days. 300,000 / μL. Break off from megakaryocytes.
Platelets. Fig Hemostasis the process by which the bleeding is stopped from broken vessels. steps involved: Vascular spasm. Platelets plug formation.
HEMOSTASIS When blood vessels are cut or damaged, the loss of blood from the system must be stopped before shock and possible death occur. This is accomplished.
HEMOSTAZA Curs an IV limba engleza HEMOSTASIS Hemostasis is defined as a property of circulation whereby blood is maintained within a vessel.
Blood Week 7 Dr. Walid Daoud A. Professor. Anemia ____________________________ Anemia is decrease in O2 carrying capacity of blood due to: 1- Decreased.
Renee Wilkins, Ph.D., MLS(ASCP) CM MLS 322 Clinical Hematology School of Health Related Professions University of Mississippi Medical Center.
Drmsaiem PLATELETS OBJECTIVES Platelets Production Platelet Structure Peripheral Zone Sol-Gel Zone Organelle Zone Platelet Function Platelet Function Tests.
Hemostasis and Blood Coagulation BS 4 th Semester Arsalan Yousuf.
HAEMOSTASIS AND VASCULAR PATHOLOGY Patrick Elder and Matt Newman.
Hemostasis and Blood Coagulation Prepared by Hamad ALAssaf
Hemostasis & Thrombosis: Platelet Disorders Beth A. Bouchard BIOC 212: Biochemistry of Human Disease Spring 2005.
CLOT FORMATION AND LYSIS FunctionConsequences of dysfunction Rapid formation of mechanically sound clot at areas of injury Bleeding Prevent clotting in.
Coagulation Disorders: Secondary Hemostasis Part One MLAB 1227: Coagulation Keri Brophy-Martinez.
Bruno Sopko. Biochemistry of haemocoagulation Laboratory test.
PLATELETS (PLTs) or Thrombocytes Dr. Taj Platelets Thrombocytes are Fragments of megakaryocytes in bone marrow.
Hemostasis/Thrombosis I Normal Hemostasis/Thrombosis; Assessment of Clotting System.
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