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Published byBrent Crowhurst Modified about 1 year ago

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Counts TLR3-PE Counts TLR8-PE Counts TLR9-PE C AB Supplemental Figure 1

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A TLR7-PE No. of living cells (in million) B PBS CL264 Cisplatin CL264+ Cisplatin Percentage (apoptotic cells) PBS CL264 Cisplatin CL264+ Cisplatin Counts ** *** Supplemental Figure 2

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PBS CL264 Cisplatin(100µM)Cisplatin(200µM) Cisplatin(300µM) CL264+Cisplatin(100µM)CL264+Cisplatin(200µM) CL264+Cisplatin(300µM) ns Tumor volume (mm 3 ) ** Supplemental Figure 3

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A B Tumor volume (mm 3 ) day CL264 Cisplatin IRS661 ODN Supplemental Figure 4

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PBS CL264 %CD3+ cells among CD45+ cells ns PBS CL nb CD3+ cells (x10 6 ) ns PBS CL264 %CD3+ CD4+ cells among CD45+ cells ns PBS CL264 nb CD3+ CD4+ cells (x10 6 ) ns CD3 + T cellsCD4 + T cells PBS CL %CD3+ CD8+ cells among CD45+ cells ns PBS CL264 nb CD3+ CD8+ cells (x10 6 ) ns CD8 + T cells PBS CL %CD3+ Foxp3+ cells among CD45+ cells ns nb CD3+ Foxp3+ cells (x10 6 ) PBS CL ns CD3 + Foxp3 + T Reg cells PBS CL %Gr1- CD11c+ cells among CD45+ cells nb Gr1- CD11c+ cells (x10 6 ) PBS CL264 Gr1 - CD11c + dendritic cells PBS CL264 %Gr1- CD11b+ cells among CD45+ cells PBS CL nb Gr1- CD11b+ cells (x10 6 ) Gr1 - CD11b + macrophages PBS CL %Gr1+ CD11b+ cells among CD45+ cells 0 PBS CL nb Gr1+ CD11b+ cells (x10 6 ) Gr1 + CD11b + MDSCs A B CD EF G ** Supplemental Figure 5

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P value Percentage of TLR7 expressing tumor cells Supplemental Figure 6

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P value Percentage of TLR7 expressing tumor cells Supplemental Figure 7

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Overall Survival (OS) Time (months) Responders =55/166 Non-responders =111/166 P = Supplemental Figure 8

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R 2 = p= % TLR7 in tumor cells in LN after chemotherapy % TLR7 in tumor cells in lung after chemotherapy Supplemental Figure 9

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No Yes % TLR7 positive tumoral cells Tumor Downstaging A B Yes No Lymph Node Downstaging % TLR7 positive tumoral cells PatientsMean %TLR7 expressing cells P value for the mean Median %TLR7 expressing cells P value for the median Tumor downstaging Yes No4750 Lymph Node downstaging Yes No51 50 C Supplemental Figure 10

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