1. Strategic Goal #5: T1 Translational Research Brian Athey University of Michigan

2. SG#5 T1 Mission Statement “The mission of the Translating Research Discoveries to Clinical Testing Strategic Goal Committee #5 is to assess the opportunities and barriers to T1 Translation and develop strategies for efficient movement of discoveries and mechanistic knowledge into clinical testing through new models of partnership (both public and private) to develop new prognostics, diagnostics, and therapeutics.”

3. Clarification of “bench to bedside” “The T1 Translational Research Strategic Goal Committee aims to accelerate T1 translational science through the improvement and development of resources for moving discoveries (markers, agents or devices) across translational barriers through "first time in humans.”

4. The Foci of the T1 Strategic Goal #5 Committee are: Development of education and training requirements for T1 investigators, leveraging focus on the following (Education and Training Theme): Encourage collaborative demonstration projects that will develop infrastructure for proof-of-concept studies in humans across different CTSA sites. Through the coalescing of smaller groups of experts around disease-oriented studies, this goal will test and grow the ability of the CTSA Consortium to lead to more rapid movement from proposal to results. Consortium and Acceleration Themes Develop efficient, effective and consistent models of technology transfer through the integration of input from the Translational and Public Private Partnerships Key Function Committees. Technology/Public-Private Partnership Themes

5. SG#5 Lead Personnel Co-Chair(s) – Don McClain (Utah) Kenneth S. Polonsky (Washington U) Eric J. Topol (Scripps) NCRR Leads— Renee Joskow (NCRR) Susan E. Old (NCRR) Lili Portilla (NCRR) Doug Sheely (NCRR)

6. CTSA Translational Steering Committee Projects Informatics Resource Web Presence Translational Resource Database Goal: Searchable database of publicly available CTSA resources For T1 research Federated Biobank Database Goal: Federated database of CTSA-associated biological repositories Pediatric Rare Disease Biobank Database Pathways of Translation Goal: Searchable map of T1 pathways and resources Workshop: Decision-making in Translational Research Goal: Consensus view of needs and priorities for T1 infrastructure, expertise, and resource access Translational Technology Training Goal: Crossover training of clinical and translational researchers Translational Technology Rounds Goal: Archived webinars on T1 technologies CTSA Imaging Working Group RSNA Support (Radiological Society of North America) Core Resources Imaging Informatics Clinical Trials Education NCI Translational Research Work Group NIH IC – CTSA Accelerator Goal: Accelerate leveraging of CTSA infrastructure by NIH programs