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1 Substance Searching in Registry,CAplus. 2 The Registry File is the recommended starting point for substance searching in CAS databases (also for Marpat)

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Presentation on theme: "1 Substance Searching in Registry,CAplus. 2 The Registry File is the recommended starting point for substance searching in CAS databases (also for Marpat)"— Presentation transcript:

1 1 Substance Searching in Registry,CAplus

2 2 The Registry File is the recommended starting point for substance searching in CAS databases (also for Marpat)

3 3 CAS RNs may be retrieved from Registry using a variety of search terms:  Dictionary  Structure  Peptide Sequences  Nucleic Acid Sequences Substances indexed in CAplus

4 4 Gold ions Locate references published on methods for detecting Gold ions in water. Skills Practice

5 5 => water/cn L1 1 WATER/CN => au/els L AU/ELS => au/mf L3 207 AU/MF => l2 not l3 L L2 NOT L3

6 6 => fil caplus => l4/ant and l1/amx L5 5 L4/ANT AND L1/AMX => d ti hit

7 7 L5 ANSWER 1 OF 5 CAPLUS COPYRIGHT 2004 ACS on STN TI Anion-exchange chromatography of metal cyanide complexes with gradient separation and direct UV detection IT , Water, analysis RL: AMX (Analytical matrix); ANST (Analytical study) (anion-exchange chromatog. of metal cyanide complexes in waters with gradient separation and direct UV detection) IT , Hexacyanoferrate , Dicyanoaurate(1-) , Dicyanoargentate(1-) , Tricyanocuprate(2-) , Hexacyanocobaltate(4-) ,TetracyanoNickelate(2-) RL: ANT (Analyte); ANST (Analytical study) (anion-exchange chromatog. of metal cyanide complexes with gradient separation and direct UV detection)

8 8 Has anyone done a crystal structure study on this compound? Find methods to prepare the organic molecule, or its salts. Skills Practice

9 9 => fil reg => C7 H9 N5 O. Cl H. H2 O/mf L2 1 C7 H9 N5 O. CL H. H2 O/MF CRN ( )

10 10 => fil caplus => l2 and cryst? L3 2 L2 AND CRYST? => d scan hitrn

11 11 L3 2 ANSWERS CAPLUS COPYRIGHT 2002 ACS IT RL: PRP (Properties) (crystal structure of) HOW MANY MORE ANSWERS DO YOU WISH TO SCAN? (1):1 L3 2 ANSWERS CAPLUS COPYRIGHT 2002 ACS IT RL: PRP (Properties) (crystal and mol. structure of)

12 12 => fil reg => L ( /RN) => /crn L /CRN => l6 or l7 L8 4 L6 OR L7 => fil caplus

13 13 => l8/prep 43 L PREP/RL L9 12 L8/PREP (L8 (L) PREP/RL) => d scan hitrn

14 14 IT P RL: SPN (Synthetic preparation); PREP (Preparation) (prepn. of)

15 15 Has anything been reported about the calcium salts of this 2-Sulfanylbenzoic acid? Is any of this salts used as monomer in polymers? Skills Practice

16 16 => c7h6o2s and ca/els L1 1 C7H6O2S AND CA/ELS IN Benzoic acid, 2-mercapto-, calcium salt (2:1) (9CI) MF C7 H6 O2 S. 1/2 Ca

17 17 => c ca o s/relf(s)nrrs=>2 and 2- mercapt?(l)(benz? or phenyl?) L4 2 C CA O S/RELF(S)NRRS=>2.. IN Calcium, [2-mercaptobenzoato(2-)-O,S]- (9CI) MF C7 H4 Ca O2 S CI COM

18 18 IN Calcium, [2-mercaptobenzoato(2-)-O,S]-, polymer with chloroethene (9CI) MF (C7 H4 Ca O2 S. C2 H3 Cl)x CI PMS

19 19 Locate references which study the pharmaceutical uses of Mg pyridoxal-5’- phosphate glutaminate salt. MF C13 H17 N2 O9 P Skills Practice*

20 20 => C13H17N2O9P/MF and nrs=1 and nc5/es 15 C13H17N2O9P/MF NRS= NC5/ES L1 3 C13H17N2O9P/MF AND NRS=1 AND NC5/ES => d scan L1 3 ANSWERS REGISTRY COPYRIGHT 2003 ACS IN L-Glutamic acid, N-[[3-hydroxy-2-methyl-5- [(phosphonooxy)methyl]-4-pyridinyl]methylene]- (9CI) MF C13 H17 N2 O9 P Absolute stereochemistry. Double bond geometry unknown.

21 21 => 13/c(p)2/n(p)1/p(p)9/o(p)mg/els L1 1 13/C(P)2/N(P)1/P(P)9/O(P)MG/ELS => 13/c(p)2/n(p)1/p(p)9/o(p)mg/els and ?pyridin?/cns L2 1 13/C(P)2/N(P)1/P(P)9/O(P)MG/ELS AND ?PYRIDIN?/CNS => 13/c(p)2/n(p)1/p(p)9/o(p)mg/els and nrrs>=1 L3 1 13/C(P)2/N(P)1/P(P)7-9/O(P)MG/ELS AND NRRS>=1

22 22

23 23 Skills Practice Isolate this compound starting with MF in /MF

24 24 Molecular Formula (/MF) Basic Index (/BI or none) (C5H8O2)x C5H8O2 (C7H10Cl2O4.C4H10N2)x C7H10Cl2O4 C4H10N2 (C12H2O4)n C12H2O4 (C2H4O)nC28H40 C2H4O (C2H4O)nC28H40 (C8H6O.(C2H4O)nH2O4)x C8H6O C2H4O (C2H4O)nH2O4 (C10H8O4)n.xNa C10H8O4 Na (C10H8O4)n ((C18H34O2)2.C14H32N2)x C18H34O2 C14H32N2 (C18H34O2)2 (C5H8O2.C3H3N)x.CH2I2 C5H8O2 C3H3N CH2I2 (C5H8O2.C3H3N)x MF Indexing for Polymers in Basic Index

25 25 => fil reg => "(c2h4o)"nc6h10o3/mf L1 12 "(C2H4O)"NC6H10O3/MF => d scan => l1 and oxiranyl OXIRANYL L2 2 L1 AND OXIRANYL => d scan

26 26

27 27 Skills Practice Isolate this compound starting with MF in BI

28 28 => c2h4o(l)"(c2h4o)n"c6h10o3 L1 600 C2H4O(L)"(C2H4O)N"C6H10O3 => l1 and 2 oc2/es and nc=1 and nrs=2 L2 4 L1 AND 2 OC2/ES AND NC=1 AND NRS=2 => d scan

29 29 MF (C2 D4 O)n C6 D10 O3 MF ((C2 D4 O)n C6 D10 O3)x MF (C2 H4 O)n C6 H10 O3 MF ((C2 H4 O)n C6 H10 O3)x

30 30 Skills Practice Isolate this compound starting with /ELF

31 31 Formula Search Fields

32 32 => ("poly("?/hp or sru) and nc=1 and c h o/elf(l)"(c h o)"n c h o/elf L ("POLY("?/HP OR SRU) AND NC=1 AND => l1 and oc2/es and nrs=2 L2 50 L1 AND OC2/ES AND NRS=2 => l2 and 8/c and 4/o and 14/h L3 4 L2 AND 8/C AND 4/O AND 14/H

33 33

34 34 Find references on the pyrene polyesters with the following structure fragments. Look at the differences between searching with the complete RID and other strings in Dictionary. Skills Practice

35 35 => fil reg => pyrene/cn L1 1 PYRENE/CN => d ide rsd L1 ANSWER 1 OF 1 REGISTRY COPYRIGHT 2002 ACS RN REGISTRY CN Pyrene (8CI, 9CI) (CA INDEX NAME)

36 36 Ring System Data Elemental | Elemental | Size of |Ring System| Ring | RID Analysis | Sequence |the Rings| Formula |Identifier|Occurrence EA | ES | SZ | RF | RID | Count ===========+===========+=========+===========+==========+======== C6-C6-C6-C6|C6-C6-C6-C6| |C16 | |1

37 37 => sel rid SmartSELECT INITIATED New TRANSFER and ANALYZE Commands Now Available See HELP TRANSFER and HELP ANALYZE for Details L2 SEL L1 1- RID : 1 TERM => polyester/pct L POLYESTER/PCT => l2 and l3 L7 74 L2 AND L3

38 38 => c6-c6-c6-c6/ea(s)16/ratc and pyren? and l3 L12 79 C6-C6-C6-C6/EA(S)16/RATC AND PYREN? AND L3 => l12 not l7 L13 5 L12 NOT L7

39 39 => d scan

40 40 Find copolymers formed by the following monomers: C8H8, (C2H4O)n and at least by another monomer containing only C H N. Isolate the polymers containing only C, H, O, N. Skills Practice

41 41 => c8h8(l)"(c2h4o)n"? L C8H8(L)"(C2H4O)N"? => l1 and c h n/elf and 4/elc.sub and pms/ci L2 216 L1 AND C H N/ELF AND.... => d mf 1-10

42 42 MF (C16 H10 O9. C10 H10 O4. C10 H10 O4. C8 H8. C3 H3 N. C2 H6 O2. (C2 H4 O)n H2 O)x MF (C8 H8. C5 H13 N O2. C3 H3 N. (C2 H4 O)n C6 H10 O3)x MF (C8 H8. C6 H11 N O. C3 H3 N. (C2 H4 O)n (C2 H4 O)n C15 H16 O2)x MF (C8 H8. C7 H7 N. (C2 H4 O)n C5 H8 O2)x

43 43 Find among the results:  polymers containing the searched SRU with an ending group formed only by H and O.  polymers containing the searched SRU with an ending group formed by C, H and O.

44 44 => "(c h o)"n h o/elf and l "(C H O)"N H O/ELF L7 35 "(C H O)"N H O/ELF AND L2 => d mf 1-10

45 45 L7 ANSWER 1 OF 35 REGISTRY COPYRIGHT 2002 ACS MF (C16 H10 O9. C10 H10 O4. C10 H10 O4. C8 H8. C3 H3 N. C2 H6 O2. (C2 H4 O)n H2 O)x L7 ANSWER 2 OF 35 REGISTRY COPYRIGHT 2002 ACS MF (C8 H8. C4 H2 O3. (C3 H6 O)n (C3 H6 O)n (C3 H6 O)n C3 H8 O3. C3 H3 N. (C2 H4 O)n H2 O)x L7 ANSWER 3 OF 35 REGISTRY COPYRIGHT 2002 ACS MF (C14 H18 O7. C9 H6 N2 O2. C8 H8. C7 H12 O2. C6 H14 O4. C6 H10 O3. C3 H4 O2. (C2 H4 O)n H2 O)x. x C6 H15 N L7 ANSWER 4 OF 35 REGISTRY COPYRIGHT 2002 ACS MF (C8 H8. C7 H7 N. C3 H4 O2. (C2 H4 O)n H2 O)x

46 46 => "(c h o)"n c h o/elf and l "(C H O)"N C H O/ELF L8 134 "(C H O)"N C H O/ELF AND L2 => d mf 1-5

47 47 L8 ANSWER 1 OF 134 REGISTRY COPYRIGHT 2002 ACS MF (C8 H8. C5 H13 N O2. C3 H3 N. (C2 H4 O)n C6 H10 O3)x L8 ANSWER 2 OF 134 REGISTRY COPYRIGHT 2002 ACS MF (C8 H8. C7 H7 N. (C2 H4 O)n C5 H8 O2)x L8 ANSWER 3 OF 134 REGISTRY COPYRIGHT 2002 ACS MF (C8 H14 O2. C8 H8. C7 H12 O2. C6 H10 O3. C3 H6 N6. C3 H4 O2. (C2 H4 O)n C5 H8 O2. C H2 O)x L8 ANSWER 4 OF 134 REGISTRY COPYRIGHT 2002 ACS MF (C16 H28 O5. C8 H14 O2. C8 H8. C7 H12 O3. C7 H12 O2. C3 H6 N6. C3 H4 O2. (C2 H4 O)n C5 H8 O2. C H2 O)x L8 ANSWER 5 OF 134 REGISTRY COPYRIGHT 2002 ACS MF (C22 H42 O2. C12 H18 O4. C8 H8. C7 H12 O2. C7 H10 O3. C6 H10 O3. C5 H8 O2. C3 H4 O2. C3 H3 N. (C2 H4 O)n C5 H8 O2)x. x H3 N

48 48 Are the thioctic acid salts with carnitine known? Consider, particularly, if the triple salts are known Skills Practice

49 49 => fil reg => s thioctic acid/cn L1 1 THIOCTIC ACID/CN => d L1 ANSWER 1 OF 1 REGISTRY COPYRIGHT 2005 ACS on STN RN REGISTRY CN 1,2-Dithiolane-3-pentanoic acid (9CI) (CA INDEX NAME)

50 50 => e carnitin/cn E3 1 --> CARNITIN/CN E4 1 CARNITINAMIDE CHLORIDE/CN E5 1 CARNITINE/CN => e3,e5 L1 2 (CARNITIN/CN OR CARNITINE/CN) CN 1-Propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, inner salt, (2R)-(9CI)

51 51 => c h o s/elf(p)8/c(p)2/o(p)2/s and s2c3/es L1 199 C H O S/ELF(P)8/C(P)2/O(P)2/S AND S2C3/ES => d scan

52 52 => c h n o/elf(p)c=>6(p)3/o(p)1/n not rsd/fa L C H N O/ELF(P)C=>6(P)3/O(P)1/N NOT RSD/FA => l2 and 1-propan?(l)3-carbox?(l)2-hydrox?(l)n(w)(dimethyl or trimethyl) L3 192 L2 AND 1-PROPAN?(L)3-CARBOX?(L)2-HYDROX?(L)N(W)..... => sel l1 rn L4 SEL L1 1- RN : 199 TERMS => sel l3 rn L5 SEL L3 1- RN : 192 TERMS

53 53 => l4/crn and l5/crn L8 8 L6 AND L7 => l8 and nc=3 L9 4 L8 AND NC=3 IN 1-Propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, (2R)-, 1,2-dithiolane-3-pentanoate, monopotassium salt (9CI) MF C8 H13 O2 S2. C7 H16 N O3. K IN 1-Propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, (2R)-, 1,2-dithiolane-3-pentanoate, monosodium salt (9CI) MF C8 H13 O2 S2. C7 H16 N O3. Na IN 1-Propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, inner salt, (2R)-, compd. with magnesium 1,2-dithiolane-3-pentanoate (1:1) (9CI) MF C8 H14 O2 S2. C7 H15 N O3. 1/2 Mg IN 1-Propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, inner salt, (2R)-, compd. with calcium 1,2-dithiolane-3-pentanoate (1:1) (9CI) MF C8 H14 O2 S2. C7 H15 N O3. 1/2 Ca

54 54 Substances indexed in CAplus

55 55 Substance index entries, in CAplus, are made when new or novel information is reported in a document about a substance Substances indexed in CAplus

56 56 There are two types of substance index terms in CAplus There are two types of substance index terms in CAplus:  CAS RNs  Subject Index Entries Substances indexed in CAplus

57 57 IT , 1-Hexadecanol RL: TEM (Technical or engineered material use); USES (Uses) (metal working oil contg. adipic acid diesters for rolling stainless steel) IT Alcohols RL: FFD (Food or feed use); BIOL (Biological study); USES (Uses) (long-chain; Saccharomyces cerevisiae yeast mutant with defect in biosynthesis of citric acid cycle enzymes use in non-alc. beer prodn.) CAS RN Index entry Subject Index entry Substances indexed in CAplus

58 58 Document TypeSubstances Indexed Journals,Reports, Etc. New Compounds Compounds with new inf. PatentsCompounds in examples. Compounds defined in claims. Review Review focus, from title Books Compounds in titles Non Indexed None

59 59 Compounds indexed from Journals, Technical Reports, etc. with novelty about:  Preparative method  Source  Property information  Reaction Study  Kinetic or mechanistic study  Detection method  Use or application  Biological effects Substances indexed in CAplus

60 60 Compounds indexed from Patents, novelty generally appears in:  Patent Examples (with supporting data)  Tables in Disclosure (with supporting data)  Patent Claims (unambiguously defined) Other claimed substances (Markush) are indexed in Marpat Substances indexed in CAplus

61 61 Compounds indexed from Reviews  The focus of the review  Mentioned in the title Substances indexed in CAplus

62 62 AN 1972:97992 CAPLUS DN 76:97992 TI DDT and other chlorinated insecticides in milk AU Uhnak, Jan CS Czech. SO Vyziva Zdravie (1971), 16(1), 21-2 CODEN: VYZDAP General Review DT Journal; General Review LA Slovak Milk IT Milk (DDT and other chlorinated insecticides of) Insecticides IT Insecticides (chlorine-contg., of milk) IT , biological studies RL: BOC (Biological occurrence); BIOL (Biological study); OCCU (Occurrence) (of milk) Substances indexed in CAplus

63 63 Compounds indexed from Books Indexing for books and dissertations is done from the title only Substances indexed in CAplus

64 64 AN 1996: CAPLUS DN 126:47009 porphyrins TI The stepwise synthesis of expanded porphyrins utilizing novel heterocyclic precursors AU Hoehner, Michael Craig CS Univ. of Texas, Austin, TX, USA SO (1996) 203 pp. Avail.: Univ. Microfilms Int., Order No. DA From: Diss. Abstr. Int., B 1996, 57(6), 3739 Dissertation DT Dissertation LA English Porphyrins IT Porphyrins RL: SPN (Synthetic preparation); PREP (Preparation) (stepwise synthesis of expanded porphyrins utilizing novel heterocyclic precursors) Substances indexed in CAplus

65 65 Non-indexed documents Documents not meeting the criteria for inclusion on print Chemical Abstracts Substances indexed in CAplus

66 66 it => d acc 1995: bib it AN 1995: CAPLUS TI Isotopic tracking of change in diet and habitat use in African elephants AU Koch, Paul L.; Heisinger, Jennifer; Moss, Cynthia; Carlson, Richard W.; Fogel, Marilyn L.; Behrensmeyer, Anna K. CS Department Geological Geophysical Sciences, Princeton University, Princeton, NJ, 08544, USA SO Science (Washington, D. C.) (1995), 267(5202), CODEN: SCIEAS; ISSN: DT Journal LA English Substances indexed in CAplus

67 67 CAS RN Indexing Generally, if a substance is identified in a document, the substance is indexed using a CAS RN. Substances indexed in CAplus

68 68 AN 1996: CAPLUS Full-textFull-text DN 124: IT , Freon , Amberlite XAD-2 RL: ARU (Analytical role, unclassified); ANST (Analytical study) (detn. of wine flavor by using Amberlite XAD-2/Freon 11 extn.) Substances indexed in CAplus

69 69 Indexing Guidelines indexed only in the specific molecular form reported in the original document In general the substance is indexed only in the specific molecular form reported in the original document Substances indexed in CAplus

70 70 Amino acids For naturally occurring amino acids the L-isomer can be assumed Indexing Guidelines Substances indexed in CAplus

71 71 Hydrates, Solvates, Labelled compounds, Ions of elements Are indexed in those forms only if stressed by autor, or relevant in the paper. Substances indexed in CAplus Indexing Guidelines

72 72 Substances indexed in CAplus Indexing Guidelines Note: Note: When you are searching sugars remember to search, the open structure, and the furanosic and the pyranosic structures, rings at 5 and 6 atoms.

73 73 Buckminsterfullerene was first detected experimentally in Find reviews in English from the last 5 years on methods for synthesizing the compound. Derivatives preparations are not intersting intersting. Substances indexed in CAplus

74 74 => Buckminsterfullerene/cn L1 1 BUCKMINSTERFULLERENE/CN => d L1 ANSWER 1 OF 1 REGISTRY RN REGISTRY CN [5,6]Fullerene-C60-Ih (9CI) OTHER NAMES: CN Buckminsterfullerene CN Fullerene Substances indexed in CAplus

75 75 => fil hcaplus => help roles => l1/prep L PREP/RL L L1/PREP (L1 (L) PREP/RL) Substances indexed in CAplus

76 76 => d kwic DP IT DP, fullerene C60, polyhydroxylated, hydroxysulfate RL: DEV (Device component use); PNU (Preparation, unclassified); PREP (Preparation); USES (Uses) (driving of electrochem. device using carbon-based cluster deriv. with improved proton cond.) Substances indexed in CAplus

77 77 => l1/rn/prep L L1/D PREP/RL L3 831 L1/RN/PREP ((L1 (NOTL) L1/D) (L) PREP/RL) => d kwic L3 ANSWER 1 OF 734 IT P, Substances indexed in CAplus

78 78 => l3 and l1/dp 536 L1/DP L4 18 L3 AND L1/DP => d kwic IT P, Fullerene RL: IMF (Industrial manufacture); PREP (Preparation) (alkali metal amino acid salt derivs.; method for preparing water-soluble salts of amino acid derivs. of fullerene) IT DP, Substances indexed in CAplus

79 79 => l3 and review/dt and english/la and py> REVIEW/DT ENGLISH/LA PY>1994 L5 9 L3 AND REVIEW/DT AND.. => d hit py Substances indexed in CAplus

80 80 DT Journal; General Review LA English IT P, Fullerene RL: SPN (Synthetic preparation); PREP (Preparation) (mols.; detonation of carbon- or nitrogen- containing explosive mol PY 2003 Substances indexed in CAplus

81 81 => e fullerenes/ct E# FREQUENCY AT TERM E1 0 2 FULLERENE-C70/CT E2 0 1 FULLERENE-C70-D5H/CT E > FULLERENES/CT Substances indexed in CAplus

82 82 => e e3+all E > Fullerenes/CT E19 UF Buckminsterfullerenes/CT E20 UF Fulleroids/CT Substances indexed in CAplus

83 83 => e17+uf(l)prep/rl(notl)(salt or ?adduct? or ?addn or comp? or polymer or complex or deriv?) L FULLERENES+UF/CT(L).. Substances indexed in CAplus

84 84 => l14 and review/dt and english/la and py> REVIEW/DT ENGLISH/LA PY>1994 L L14 AND REVIEW/DT AND ENGLISH/LA AND PY>1994 Substances indexed in CAplus

85 85 => l15 not l6 L16 79 L15 NOT L6 => d scan Substances indexed in CAplus

86 86 TI Endohedral rare-gas radiofullerenes by nuclear recoil IT Fullerenes RL: SPN (Synthetic preparation); PREP (Preparation) Substances indexed in CAplus

87 87 => fil reg => Buckminsterfullerene/cn L1 1 BUCKMINSTERFULLERENE/CN => set smart on SET COMMAND COMPLETED => sel name SmartSELECT INITIATED New TRANSFER and ANALYZE Commands Now Available See HELP TRANSFER and HELP ANALYZE for Details L2 SEL L1 1- NAME : 21 TERMS Substances indexed in CAplus

88 88 => fil hcaplus => l2 and nonindexed/fs L6 915 L5 AND NONINDEXED/FS => l6 and review/dt and english/la and py>1994 L7 4 L6 AND REVIEW/DT AND ENGLISH/LA AND PY>1994 Substances indexed in CAplus

89 89 Imigran Locate analytical studies with methods for detecting Imigran Substances indexed in CAplus

90 90 Substances indexed in CAplus => fil reg => imigran/cn L1 1 IMIGRAN/CN => sel l1 name SmartSELECT INITIATED New TRANSFER and ANALYZE Commands Now Available See HELP TRANSFER and HELP ANALYZE for Details L4 SEL L1 1- NAME : 9 TERMS

91 91 Substances indexed in CAplus => fil hcaplus => l1/ant 70 L ANT/RL L5 13 L1/ANT (L1 (L) ANT/RL)

92 92 Substances indexed in CAplus => This Predefined Search Strategy is designed to be used in the CA File in combination with search terms for your analyte or sample. FOR EXAMPLE: If L1 contains the results from a search in the Registry File using names, formulas, structures, etc. for the substances you are interested in, and if L7 is the final L-number created by this Predefined Search Strategy, then you should use the following overall strategy => search L1 (L) L7 Running CAALL.PSS

93 93 Substances indexed in CAplus L7 QUERY ANAL OR ANALY? OR ASSAY? OR DETN OR DETERMIN? OR DETECT? L8 QUERY TITR? OR CHROMATOG? OR HPLC OR TLC OR ELECTROPHORESIS OR L9 QUERY MICROANAL? OR ULTRAMICROANAL? OR MICROASSAY? OR MICRODET? L10 QUERY ELECTROANAL? OR SPECTROANAL? OR THERMOANAL? OR RADIOASSAY L11 QUERY BIOANAL OR BIOANALY? OR IMMUNOANAL? OR BIOASSAY? OR ELECT L12 QUERY L7 OR L8 OR L9 OR L10 OR L11 Running CAALL.PSS

94 94 Substances indexed in CAplus => l4(l)l12 L14 23 L13(L)L12 => l14 not l5 L15 11 L14 NOT L5 => d kwic

95 95 Substances indexed in CAplus L15 ANSWER 1 OF 11 HCAPLUS COPYRIGHT 2003 ACS TI Development and validation of an LC assay for sumatriptan succinate residues on surfaces in the manufacture of pharmaceuticals

96 96 Locate journal articles published since 1997 on methods for detecting the pesticide Alachlor. Skills Practice

97 97 => fil reg => alachlor/cn L1 1 ALACHLOR/CN => sel name SmartSELECT INITIATED New TRANSFER and ANALYZE Commands Now Available See HELP TRANSFER and HELP ANALYZE for Details L2 SEL L1 1- NAME : 17 TERMS => d 1-17

98 98 TERM # # OCC # DOC % DOC NAME ALACHLOR ALANEX ALAPAZ CP LASAGRIN LASSO LAZO METACHLOR METHACHLOR MICRO-TECH NITALA PERFECT (HERBICIDE) PERFECT SATOCHLOR CHLORO-N CHLORO-2‘ ',6'-DIETHYL-...

99 99 => fil hcaplus => l1/ant 3257 L ANT/RL L3 429 L1/ANT (L1 (L) ANT/RL) => l3 and journal/dt and py> JOURNAL/DT PY>1996 L4 164 L3 AND JOURNAL/DT AND PY>1996 => d scan

100 IT , 2,4-D, analysis , Aldicarb , Carbofuran , Atrazine , Carbendazim , Alachlor RL: ANT (Analyte); ANST (Analytical study)

101 101 => l2 (s)(det? or ?anal? or assay) L7 713 L6 (S)(DET? OR ?ANAL? OR ASSAY) => l7 and journal/dt and nonindexed/fs and py>1996 L8 7 L7 AND JOURNAL/DT AND NONINDEXED/FS AND PY>1996 => d scan You can use also CAALL.PSS File

102 102 TI Determination of alachlor and its metabolites in rat plasma and urine by liquid chromatography-electrospray ionization mass spectrometry ST alachlor metabolite detn plasma urine liq chromatog mass spectrometry IT Blood analysis Urine analysis (detn. of alachlor....

103 103 => l4 or l8 L9 170 L4 OR L8

104 104 Locate patents and articles since 1996 on uses for the polymer Maruka Lyncur M, uses of derivatives are not of interest. Include non-indexed documents. Skills Practice

105 105 => fil reg => maruka lyncur m/cn L1 1 MARUKA LYNCUR M/CN => sel name SmartSELECT INITIATED New TRANSFER and ANALYZE Commands Now Available See HELP TRANSFER and HELP ANALYZE for Details L2 SEL L1 1- NAME : 45 TERMS => fil hcaplus

106 106 => l1/uses 1918 L USES/RL L L1/USES (L1 (L) USES/RL) => l3 and l1/d 746 L1/D L4 606 L3 AND L1/D => d scan hit

107 107 IT DP, Ethyl vinyl ether, reaction products with poly(hydroxystyrene) DP DP, Poly(p-hydroxystyrene), reaction products with Et vinyl ether RL: IMF (Industrial manufacture); PRP (Properties); TEM (Technical or USES (Uses) engineered material use); PREP (Preparation); USES (Uses)

108 108 => l1/rn/uses 1918 L1 746 L1/D USES/RL L5 941 L1/RN/USES ((L1 (NOTL) L1/D) (L) USES/RL) => d scan hit

109 IT , Poly(p-hydroxystyrene) , p-Hydroxystyrene-styrene copolymer USES (Uses) RL: TEM (Technical or engineered material use); USES (Uses) (radiation resist compn. contg. sulfonic acid onium salt as acid generator)

110 110 => l5 and (journal or patent)/dt and py> JOURNAL/DT PATENT/DT PY>1995 L6 419 L5 AND (JOURNAL OR PATENT)/DT AND PY>1995 => d ti hitrn

111 111 IT , Maruka Lyncur M RL: TEM (Technical or engineered material use); USES (Uses) (masks and thermal, pos.-working mask precursors from substrates with layer of film forming polymer with at least one IR-absorbing group for fabricating electronic parts)

112 112 => d l2 1- L2 SEL L1 1- NAME : 45 TERMS TERM # # OCC # DOC % DOC NAME MARUKA LYNCUR M-H

113 113 => l2 and (journal or patent)/dt and py>1995 and nonindexed/fs SmartSELECT INITIATED New TRANSFER and ANALYZE Commands Now Available See HELP TRANSFER and HELP ANALYZE for Details SEL L2 1-16,19-23,27-45 L11 SEL L2 1-16,19-23,27-45 : 40 TERMS S L11 AND (JOURNAL OR PATENT)/DT AND PY>1995 AND NONINDEXED/FS L13 15 L12 AND (JOURNAL OR PATENT)/DT AND PY>1995 AND NONINDEXED/FS

114 114 => l13 not l6 L16 12 L13 NOT L6 => d scan hit poly(4-hydroxystyrene) TI Resonant Auger spectroscopy of poly(4-hydroxystyrene)

115 115 Resveratrol Locate reviews discussing the biological activity of Resveratrol. ( Think about different ways substances might be indexed for review documents ) Skills Practice

116 116 => fil reg => resveratrol/cn L1 1 RESVERATROL/CN => d cn

117 117 CN 1,3-Benzenediol, 5-[(1E)-2-(4- hydroxyphenyl)ethenyl]- (9CI) CN 1,3-Benzenediol, 5-[2-(4- hydroxyphenyl)ethenyl]-, (E)- CN 3,4',5-Stilbenetriol (7CI, 8CI) CN Resveratrol (6CI) OTHER NAMES: CN (E)-5-(p-Hydroxystyryl)resorcinol CN (E)-Resveratrol CN 3,5,4'-Trihydroxystilbene CN CA 1201 CN trans-Resveratrol

118 118 => fil caplus => l1/biol and review/dt 878 L BIOL/RL 732 L1/BIOL (L1 (L) BIOL/RL) REVIEW/DT L2 55 L1/BIOL AND REVIEW/DT

119 119 => (resveratrol or stilbenetriol? or trihydroxystilben? or trihydroxy stilben?) and review/dt L5 80 (RESVERATROL OR STILBENETRIOL? OR TRIHYDROXYSTILBEN? OR TRIHYDROXY STILBEN?) AND REVIEW/DT => l2 or l5 L6 80 L2 OR L5

120 120 => l6 and bio/sc BIO/SC L7 78 L6 AND BIO/SC => d scan

121 121 TI Resveratrol ST review resveratrol grape wine antitumor effect IT Grape Wine (antitumor effect of resveratrol in)

122 122 Class Identifiers ALLOY CONCEPT COORDINATION GENERIC INCOMPLETELY DEFINED MANUAL MINERAL MIXTURE POLYMER RADICAL ION RING PARENT TABULAR INORGANIC UVCB

123 123 CONCEPT - /CTS GENERIC REGISTRATION - /GRS UVCB = CTS or GRS Class Identifiers

124 124 => cts/ci L CTS/CI => grs/ci L GRS/CI => (grs or cts)/ci L (GRS OR CTS)/CI => uvcb/ci L UVCB/CI Class Identifiers

125 125 => d l1 50 L1 ANSWER 50 OF REGISTRY... RN REGISTRY * * Use of this CAS Registry Number alone as a search term in other STN files may result in incomplete search results. For additional information, enter HELP RN* at an online arrow prompt (=>). CN Siloxanes and Silicones, MF Unspecified CTS CI PMS, MAN, CTS Class Identifiers

126 126 => d l2 50 L2 ANSWER 50 OF REGISTRY.... RN REGISTRY * * Use of this CAS Registry Number alone as a search term in other STN files may result in incomplete search results. For additional information, enter HELP RN* at an online arrow prompt (=>). CN Iron, chloro diethylene glycol.... MF Unspecified GRS CI MAN, GRS Class Identifiers

127 127 (Concepts) CTS (Concepts) Generally the CA Index Name contains the compound class subject term (CT), used in Caplus to index the substance. Often the name includes modifying terms indicating the type of derivative. Class Identifiers

128 128 Class Identifiers RN REGISTRY * * Use of this CAS Registry Number alone as a search term in other STN files may result in incomplete search results. For additional information, enter HELP RN* at an online arrow prompt (=>). CN Polyolefin rubber, butene-propene (CA INDEX NAME)

129 129 Class Identifiers => fil caplus => e polyolefin rubber/ct E# FREQUENCY AT TERM E1 1 POLYOLEFIN FIBERS, USES/CT E2 0 2 POLYOLEFIN REACTION PRODUCTS/CT E > POLYOLEFIN RUBBER/CT => e e3+nt E65 NT1 Rubber, synthetic (L) butene-propene/CT

130 130 Class Identifiers => e65 L4 16 "RUBBER, SYNTHETIC (L) BUTENE-PROPENE"/CT => REG1stRY INITIATED L6 0 L5 => polyolefin(1a)(prop?(1a)(buten or butyl?)) L7 30 POLYOLEFIN(1A)(PROP?(1A)(BUTEN OR BUTYL?)) => (rubber or polyolefin)(1a)(prop?(1a)(buten or butyl?)) L (RUBBER OR POLYOLEFIN)(1A)(PROP?(1A)(BUTEN OR BUTYL?))

131 131 Find information about the substance called Protectol KLC Class Identifiers

132 132 => protectol klc/cn L1 1 PROTECTOL KLC/CN => d rn cn ci L1 ANSWER 1 OF 1 REGISTRY COPYRIGHT 2002 ACS RN REGISTRY * * Use of this CAS Registry Number alone as a search term in other STN files may result in incomplete search results. For additional information, enter HELP RN* at an online arrow prompt (=>). Quaternary ammonium compounds CN Quaternary ammonium compounds, benzyl-C alkyldimethyl, chlorides (CA INDEX NAME) OTHER NAMES: Alkylbenzyldimethylammonium chlorides CN Alkylbenzyldimethylammonium chlorides, benzyl-C12-14-alkyldimethyl CTS CI MAN, CTS Class Identifiers

133 133 => fil hcaplus => e Quaternary ammonium compounds/ct E# FREQUENCY AT TERM E QUATERNARY AMMONIUM CHLORIDES/CT E14 1 QUATERNARY AMMONIUM COMPDS./CT E > QUATERNARY AMMONIUM COMPOUNDS/CT Class Identifiers

134 134 => e e15+all E BT2 Organic compounds/CT E BT1 Onium compounds/CT E > Quaternary ammonium compounds/CT HN Valid heading during volume 76 (1972) to present. E28 1 OLD Ammonium compounds, substituted/CT Class Identifiers

135 135 => e27+old,uf(l)?benzyl?(l)?dimethyl?(l)(c12(w) (14 or c14)) L2 71 "QUATERNARY AMMONIUM COMPOUNDS"+OLD,UF/CT (L)?BENZYL?(L)?DIMETHYL?(L)(C12(W)(14 OR C14)) => d scan hit Class Identifiers

136 136 IT Quaternary ammonium compounds, uses RL: MOA (Modifier or additive use); USES (Uses) (benzyl-C12-14-alkyldimethyl,..... Class Identifiers

137 137 => e Alkylbenzyldimethylammonium chlorides/ct E# FREQUENCY AT TERM E ALKYLBENZYLDIMETHYLAMMONIUM/CT E ALKYLBENZYLDIMETHYLAMMONIUM BROMIDES/CT E > ALKYLBENZYLDIMETHYLAMMONIUM CHLORIDES/CT Class Identifiers

138 138 => e e111+all E > Alkylbenzyldimethylammonium chlorides/CT E122 USE Quaternary ammonium compounds(L) alkylbenzyldimethyl, chlorides/CT Class Identifiers

139 139 => e111(l)(c12(w)(14 or c14)) 440 "ALKYLBENZYLDIMETHYLAMMONIUM CHLORIDES"/CT C C14 L3 5 "ALKYLBENZYLDIMETHYLAMMONIUM CHLORIDES"/CT(L)(C12(W)(14 OR C14)) Class Identifiers

140 140 => d scan hit L3 5 ANSWERS HCAPLUS COPYRIGHT 2002 ACS IT Alkylbenzyldimethylammonium chlorides RL: TEM (Technical or engineered material use); USES (Uses) (C12-14 alkyl; water-thinned wood preservation conc. contg. fungicides) Class Identifiers

141 141 => fil reg => sel l1 name SmartSELECT INITIATED New TRANSFER and ANALYZE Commands Now Available See HELP TRANSFER and HELP ANALYZE for Details L4 SEL L1 1- NAME : 12 TERMS Class Identifiers

142 142 => fil hcaplus => d l L4 SEL L1 1- NAME : 12 TERMS TERM # # OCC # DOC % DOC NAME ALKYLBENZYLDI B 50 (SURFACTANT) B BAS E Class Identifiers

143 143 => l4 SmartSELECT INITIATED New TRANSFER and ANALYZE Commands Now Available See HELP TRANSFER and HELP ANALYZE for Details SEL L4 2,4,7-10,12 L5 SEL L4 2,4,7-10,12 : 7 TERMS S L5 L6 30 L5 Class Identifiers

144 144 => l2 or l3 or l6 L7 86 L2 OR L3 OR L6 => l6 not (l2 or l3) L8 10 L6 NOT (L2 OR L3) => d scan ti it Class Identifiers

145 145 IT Quaternary ammonium compounds, uses and miscellaneous RL: USES (Uses) (di-C16-18-alkyldimethyl, chlorides, parting materials, for unsatd Class Identifiers

146 146 GRS (Generic Registration) If the CI Index contains the code GRS this compound is indexed in Caplus at the known part of the structure. The CAS RN is appended with a “D” (“D” started only from 1976) Class Identifiers

147 147 => L ( /RN) => d Class Identifiers

148 148 L1 ANSWER 1 OF 1 REGISTRY COPYRIGHT 2002 ACS RN REGISTRY * * Use of this CAS Registry Number alone as a search term in other STN files may result in incomplete search results. For additional information, enter HELP RN* at an online arrow prompt (=>). 1,1'-Biphenyl CN 1,1'-Biphenyl, chloro derivs. (CA INDEX NAME) MF Unspecified GRS CI MAN, GRS ) 3 REFERENCES IN FILE CAPLUS (1967 TO DATE) Class Identifiers

149 149 => "1,1'-biphenyl"/cn L2 1 "1,1'-BIPHENYL"/CN => fil caplus Class Identifiers

150 150 => l1 or l2/d(l)?chlor? L L1 OR L2/D(L).... => d scan hit Class Identifiers

151 151 IT D, Biphenyl, chloro derivs. RL: BSU (Biological study, unclassified); BIOL (Biological study) (synthetic prepn. and identification of new mutagenic polychlorinated biphenyl deriv. in Waka River, Wakayama, Japan, showing activation of aryl hydrocarbon receptor) Class Identifiers

152 152 Class Identifiers RN REGISTRY * * Use of this CAS Registry Number alone as a search term in other STN files may result in incomplete search results. For additional information, enter HELP RN* at an online arrow prompt (=>). CN Phenol, 4,4'-(1-methylethylidene)bis-, polymer with (chloromethyl)oxirane and methyloxirane, reaction products with diethanolamine and diisopropanolamine MF Unspecified CI PMS, MAN, GRS Reaction products

153 153 Class Identifiers Reaction products => fil reg => diethanolamine/cn L2 1 DIETHANOLAMINE/CN => diisopropanolamine/cn L3 1 DIISOPROPANOLAMINE/CN

154 154 Class Identifiers Reaction products => fil hcaplus => e phenols/ct E# FREQUENCY AT TERM E > PHENOLS/CT => e38+nt L PHENOLS+NT/CT (415 TERMS)

155 155 Class Identifiers Reaction products => l4(l)react?(l)produc? L L4(L)REACT?(L)PRODUC? => l5 and l2 and l L L3 L6 18 L5 AND L2 AND L3

156 156 Class Identifiers Reaction products => d hit L6 ANSWER 1 OF 18 HCAPLUS COPYRIGHT 2003 ACS IT DP, Diisopropanolamine, reaction products with nonylphenol and epoxy resins DP, Diethanolamine, reaction products with nonylphenol

157 157 Class Identifiers Reaction products RN REGISTRY * * Use of this CAS Registry Number alone as a search term in other STN files may result in incomplete search results. For additional information, enter HELP RN* at an online arrow prompt (=>). CN 1,2-Benzenedicarboxylic acid, mixed esters with benzyl alc., cyclohexanol, 2-ethyl-1-hexanol, fumaric acid and propylene glycol (CA INDEX NAME) MF Unspecified CI MAN, GRS

158 158 Class Identifiers Reaction products => fil reg => 1,2-benzenedicarboxylic acid/cn L1 1 1,2-BENZENEDICARBOXYLIC ACID/CN => benzyl alcohol/cn L2 1 BENZYL ALCOHOL/CN => cyclohexanol/cn L3 1 CYCLOHEXANOL/CN => 2-ethyl-1-hexanol/cn L4 1 2-ETHYL-1-HEXANOL/CN => fumaric acid /cn L5 1 FUMARIC ACID /CN => propylene glycol/cn L6 1 PROPYLENE GLYCOL/CN

159 159 Class Identifiers Reaction products => fil hcaplus => e 1,2-benzenedicarboxylic acid/ct E# FREQUENCY AT TERM E > 1,2-BENZENEDICARBOXYLIC ACID/CT => e e3+all E > 1,2-Benzenedicarboxylic acid/CT E14 0 USE Phthalic acid/CT ********* END***

160 160 Class Identifiers Reaction products => (l1/d or e14)(l)ester? 2804 L1/D 8461 "PHTHALIC ACID"/CT (1 TERM) ESTER? L (L1/D OR "PHTHALIC ACID"/CT)(L)ESTER? => l7 and l L2 L8 36 L7 AND L2

161 161 Class Identifiers Reaction products => d hit L8 ANSWER 1 OF 36 HCAPLUS COPYRIGHT 2003 ACS IT , Propylene glycol, uses D, Acrylic acid, ester, polymers with siloxanes D, Phthalic acid, ester , Benzyl alcohol,

162 162 Class Identifiers Reaction products => l7 and l L3 L9 18 L7 AND L3 => l7 and l L4 L10 60 L7 AND L4 => l7 and l L5 L11 35 L7 AND L5 => l7 and l L6 L12 37 L7 AND L6

163 163 Searching IDS

164 164 Search the following structure:

165 165 Structure searched

166 166 SEARCH CHARGES Answer in Registry 1 Aswer in CAPlus AN 2004: CAPLUS DN 141: DT Journal

167 167

168 168 Structure searched

169 169 Structure searched

170 170 SEARCH CHARGES Answers in Registry 2 Aswer in CAPlus AN 2005: CAPLUS DN 143: DT Patent (not in MARPAT) AN 2004: CAPLUS DN 141: DT Journal

171 171

172 172

173 173 c6/es(p)nonc2/es and 4/n(p)9/o and glutam? c6/es(p)nonc2/es and 4/n(p)9/o and glutam? and cnrs=>2 and c h n o/elf and nc=1 5 answers in Registry 5 answers in Registry SEARCH CHARGES 36.80

174 174 Find all non-polymeric glycerides containing oleic and/or stearic fatty acid that are used, in patents, for drug delivery. Skills Practice

175 175 CN 9-Octadecenoic acid (9Z)- (9CI) (CA INDEX NAME) OTHER CA INDEX NAMES: CN 9-Octadecenoic acid (Z)- CN Oleic acid (8CI) MF C18 H34 O2

176 176 CN Octadecanoic acid (9CI) (CA INDEX NAME) OTHER CA INDEX NAMES: CN Stearic acid (8CI) MF C18 H36 O2

177 177 CN 1,2,3-Propanetriol (9CI) (CA INDEX NAME) OTHER CA INDEX NAMES: CN Glycerol (8CI) CN Propanetriol (7CI) MF C3 H8 O3

178 178 Remarkable hints for search strategy: 1)The esterification, with the two acids, can occur in three different points 2)Other acids can be present 3)Is it reasonable to think about IDS compounds?

179 179 => fil reg => c h o/elf(p)21-57/c(p)4-6/o not (pms/ci or rsd/fa) L C H O/ELF(P)21-57/C(P)4-6/O NOT (PMS/CI OR RSD/FA) => Uploading C:\Program Files\stnexp\Queries\13.str Conn.=2

180 180 => l2 full subset=l1 L SEA SUB=L1 SSS FUL L2 IN Eicosanoic acid, 3-[(1-oxododecyl)oxy]-2-[[(9Z)-1-oxo-9- octadecenyl]oxy]propyl ester (9CI) MF C53 H100 O6

181 IDS compounds present in this set IN Octadecanoic acid, 1-ester with 1,2,3-propanetriol monoacetate (9CI) MF C23 H44 O5 CI IDS Octadecenoic acid IN Octadecenoic acid, 2,3-bis(octadecyloxy)propyl ester (7CI, 9CI) MF C57 H112 O4 CI IDS

182 182 => l1 and (propan? or glycer?)/cns(l)(octadecen? or oleic? or octadecan? or stear?) L L1 AND (PROPAN? OR GLYCER?)/CNS(L) extra IDS compounds present in this set

183 183 IN 9-Octadecenoic-9,10-t2 acid, diester with 1,2,3-propanetriol, (9Z,9'Z)- (9CI) MF C39 H68 O5 T4 CI IDS IN 9,12-Octadecadienoic acid (9Z,12Z)-, ester with 1,2,3-propanetriol di-(Z)-octadecenoate di-(Z)-octadecenoate (9CI) MF C57 H102 O6 CI IDS

184 184 => l4 or l3 L L4 OR L3 => oleic acid/cn L8 1 OLEIC ACID/CN => stearic acid/cn L9 1 STEARIC ACID/CN => glycerol/cn L10 1 GLYCEROL/CN => fil hcaplus => e drug delivery/ct

185 185 => l7(l)(deliv? or dosag? or releas? or capsul?) and p/dt L L7(L)(DELIV? OR DOSAG? OR RELEAS? OR => d hitstr

186 186 => l10/d(l)(oleic? or stear? or c18 or 18 or octadec?) L12 86 L10/D(L)(OLEIC? OR STEAR? OR C18 OR 18 OR OCTADEC?) => l9/d(l)glycerid? L13 38 L9/D(L)GLYCERID? => l8/d(l)glycerid? L14 43 L8/D(L)GLYCERID? => (l12 or l13 or l14)(l)(deliv? or dosag? or releas? or capsul?) and p/dt L15 6 (L12 OR L13 OR L14)(L)(DELIV? OR DOSAG? OR RELEAS? OR => l15 not l11 L16 5 L15 NOT L11

187 187 => d kwic L16 ANSWER 1 OF 5 HCAPLUS COPYRIGHT 2003 ACS DT Patent IT D, Palmitic acid, glycerides D, Stearic acid,glycerides prolonged-release microspheres

188 188 Find information on the effect of diatomaceous earth on the lungs Skills Practice

189 189 => diatomaceous earth/cn L1 1 DIATOMACEOUS EARTH/CN => d L1 ANSWER 1 OF 1 REGISTRY COPYRIGHT 2002 ACS RN REGISTRY * * Use of this CAS Registry Number alone as a search term in other STN files may result in incomplete search results. For additional information, enter HELP RN* at an online arrow prompt (=>). Kieselguhr CN Kieselguhr (CA INDEX NAME) OTHER NAMES: CN Aquafil N 81 CTS CI COM, MAN, CTS

190 190 => sel name SmartSELECT INITIATED New TRANSFER and ANALYZE Commands Now Available See HELP TRANSFER and HELP ANALYZE for Details L2 SEL L1 1- NAME : 152 TERMS => fil hcaplus

191 191 => e Kieselguhr/ct E# FREQUENCY AT TERM E1 0 2 KIESELGEL/CT E2 0 2 KIESELGEL 40/CT E > KIESELGUHR/CT

192 192 => e e3+all E > Kieselguhr/CT HN Valid heading during volumes ( ) only. E NEW Diatomite/CT ********* END***

193 193 => e e14+all..... E > Diatomite/CT HN Valid heading during volume 126 (1997) to present. E26 1 OLD Chromosorb G/CT E27 1 OLD Chromosorb W/CT E OLD Kieselguhr/CT..... => e25+old,uf L DIATOMITE+OLD,UF/CT (146 TERMS)

194 194 => e lung/ct E# FREQUENCY AT TERM E LUNELLA CORNATA COREENSIS/CT E LUNELLA CORONATUS/CT E > LUNG/CT

195 195 => e e178+all E > Lung/CT HN Valid heading during volume 76 (1972) to present. E OLD Lungs/CT => e192+all L LUNG+ALL/CT (36 TERMS) => l3 and l4 L5 19 L3 AND L4

196 196 => d scan IT Kieselguhr RL: IMF (Industrial manufacture); PREP (Preparation) (air pollution and manuf. of, lung disorder in workers exposed to) IT Lung, composition (silica and cristobalite in, of deceased workers in kieselguhr industry)

197 197 => l2(l)l4 L9 11 L8(L)L4 => l9 not l5 L10 1 L9 NOT L5 => d scan

198 198 IT Death Environmental modeling Epidemiology Industrial hygiene Lung, neoplasm Occupational health Risk assessment Simulation and Modeling, biological (quant. risk assessment of lung cancer mortality from cryst. silica exposure in diatomaceous earth industry workers)

199 199 => e25-e170/bi L (DIATOMITE/BI OR... => e192-e223/bi L (LUNG/BI OR..... => (l2 or l17)(l)l18 L20 68 (L19 OR L17)(L)L18 => l20 not (l5 or l9) L21 54 L20 NOT (L5 OR L9) => d scan

200 200 TI Biogenic amorphous silica ST review biogenic silica health hazard IT Air pollution (biogenic amorphous silica and its potential health hazards in relation to) IT Diatom

201 201 Find information from 1990 on the adverse effects of chlorinated phenols. A CAS RN is Skills Practice

202 202 => L ( /RN) => d rn cn ci L1 ANSWER 1 OF 1 REGISTRY COPYRIGHT 2002 ACS RN REGISTRY * * Use of this CAS Registry Number alone as a search term in other STN files may result in incomplete search results. For additional information, enter HELP RN* at an online arrow prompt (=>). Phenol CN Phenol, chloro derivs. (CA INDEX NAME) OTHER NAMES: CN Phenol, chlorinated GRS CI MAN, GRS

203 203 => d rn mf L2 ANSWER 1 OF 1 REGISTRY COPYRIGHT RN REGISTRY MF C6 H6 O => phenol/cn L2 1 PHENOL/CN

204 204 => (c6h5clo or c6h4cl2o or c6h3cl3o or c6h2cl4o or c6hcl5o)/mf and phen?/ins.hp L4 102 (C6H5CL OR C6H4CL2O...

205 205 => fil hcaplus => l4/adv and py>1989 L8 934 L4/ADV AND PY>1989 => (l2/d(l)(?chlor? or halo?)(l) adv/rl) and py>1989 L9 69 (L2/D(L)(?CHLOR? OR HALO?)(L)ADV/RL) AND PY>1989

206 206 => d scan IT D, Phenol, derivs. RL: ADV (Adverse effect, including toxicity); => l8 not l9 L L8 NOT L9 => d scan

207 207 IT , Pentachlorophenol RL: ADV (Adverse effect, including toxicity);

208 208 => phenol/it(1a)(?chlor? or halo?)(l) (adv/rl or adv? or tox?) ran=1967,1976 L3 6 PHENOL/IT(1A)(?CHLOR? OR HALO?)(L) => d scan

209 209 Phenol IT Phenol, chloro RL: ADV (Adverse effect, including toxicity); Phenol IT Phenol, pentachloro-, RL: ADV (Adverse effect, including toxicity);

210 210 Find the vaporization latent heat of :    Skills Practice

211 211 => fil stnguide => vapor?(l)(enthal? or heat?) L1 6 VAPOR?(L)(ENTHAL? OR HEAT?) => (vaporiz?(1a)enthalp?)/prop L1 6 (VAPORIZ?(1A)ENTHALP?)/PROP DBN BEILSTEIN - BEILSTEIN File of Organic Compounds DBN ZREGISTRY - CAS Registry File DBN HSDB - Hazardous Substances Databank DBN DIPPR - AIChE Design Institute for Physical Properties DBN GMELIN - Gmelin Handbook of Inorganic Chemistry DBN REGISTRY - CAS Registry File

212 212 => and hvap/fa L AND HVAP/FA => d qrd CODE| VALUE | CONDITION | TYPE |NOTE ====+==================+================+==========+==== HVAP|48210+/-3000 J/mol|Press: Pa|Predicted |(1) (1)Calculated using Advanced Chemistry Development (ACD/Labs) 

213 213 => d lc L1 ANSWER 1 OF 1 REGISTRY COPYRIGHT 2006 ACS on STN LC STN Files: ANABSTR, AQUIRE, BEILSTEIN*, BIOSIS, CA, CAOLD, CAPLUS, CASREACT, CHEMCATS, CHEMLIST, CHEMSAFE, CIN, CSCHEM, CSNB, DETHERM*, DIPPRHSDB DIPPR*, HSDB*, IFICDB, IFIPAT, IFIUDB, MEDLINE, MSDS-OHS, NIOSHTIC, PDLCOM*, PROMT, RTECS*, SCISEARCH, SPECINFO, TOXCENTER, ULIDAT, USPAT2, USPATFULL

214 214 => fil dippr => and hvap/fa L AND HVAP/FA RN DIPPR HVAP Enthalpy of Vaporization (saturation pressure) Units: J/mol Temp Accept K Value Code E+04 reject E+04* accept Property and Equation Coefficients Information A B C D E HVAP E E-01 Enthalpy of Vaporization (saturation pressure) Units: J/kmol Min Temp (K): Value: E+07 Max Temp (K): Value: E+00 Eqn: Y=A*(1-Tr)**(B+C*Tr+D*Tr**2+E*Tr**3) (< 25% err) *Note: Data calculated from Clapeyron equation used in regression.

215 215 => and hvap/fa L AND HVAP/FA => L ( /RN) => d 

216 216 RN REGISTRY CN Benzene, 1,1'-methylenebis[isocyanato- (9CI) (CA INDEX NAME) OTHER CA INDEX NAMES: CN Isocyanic acid, methylenediphenylene ester (6CI, 7CI, 8CI) MF C15 H10 N2 O2 IDS CI IDS, COM LC STN Files: ANABSTR, CA, CAOLD, CAPLUS, CHEMLIST, CSNB, IFICDB, IFIPAT, IFIUDB, MSDS-OHS, NIOSHTIC, TOXCENTER, ULIDAT, USPAT2, USPATFULL Other Sources: DSL**, EINECS**, TSCA**

217 217 => c15h10n2o2/mf and (benzene or isocyanic acid)/hp(l)("1,1'"-methylenebis(l) isocyanato or methylenediphenylene) L3 4 C15H10N2O2/MF AND => d scan

218 218

219 219 => l3 and hvap/fa L4 3 L3 AND HVAP/FA => d lc hvap LC STN Files: AGRICOLA, ANABSTR, AQUIRE, BEILSTEIN*, BIOSIS, BIOTECHNO, CA, CAOLD, CAPLUS, CASREACT, CBNB, CHEMCATS, CHEMINFORMRX, CHEMLIST, CHEMSAFE, CIN, CSCHEM, CSNB, DETHERM*, DIPPR*, EMBASE, ENCOMPLIT, ENCOMPLIT2, ENCOMPPAT, ENCOMPPAT2, GMELIN*, HSDB*, IFICDB, IFIPAT, IFIUDB, MEDLINE, MSDS-OHS, NIOSHTIC, PDLCOM*, PIRA, PROMT, RTECS*, SCISEARCH, SPECINFO, TOXCENTER, ULIDAT, USPAT2, USPATFULL, VTB (*File contains numerically searchable property data) Other Sources: DSL**, EINECS**, TSCA** (**Enter CHEMLIST File for up-to-date regulatory information) CODE| VALUE | CONDITION | TYPE |NOTE ====+==================+================+==========+==== HVAP|62060+/-3000 J/mol|Press: Pa|Predicted |(1) (1) Calculated using Advanced Chemistry Development

220 220 => and hvap/fa L AND HVAP/LC => L ( /RN) => d 

221 221 RN REGISTRY * * Use of this CAS Registry Number alone as a search term in other STN files may result in incomplete search results. For additional information, enter HELP RN* at an online arrow prompt (=>). CN 1,2-Benzenedicarboxylic acid, diundecyl ester, branched and linear (CA INDEX NAME) MF Unspecified CI IDS, MAN, GRS SR Commission of European Communities LC STN Files: CHEMLIST Other Sources: DSL**, EINECS**, TSCA** (**Enter CHEMLIST File for up-to-date regulatory information) *** STRUCTURE DIAGRAM IS NOT AVAILABLE ***

222 222 => c h o/elf and 1,2-Benzenedicarboxylic acid(l)diundecyl ester and nc=1 L3 1 C H O/ELF AND => l3 and hvap/fa L4 1 L3 AND HVAP/FA => d str lc hvap

223 223 LC STN Files: ANABSTR, AQUIRE, BEILSTEIN*, BIOSIS, CA, CAOLD, CAPLUS, CHEMCATS, CHEMLIST, CIN, CSCHEM, DIPPR*, HSDB*, IFICDB, IFIPAT, IFIUDB, NIOSHTIC, PROMT, RTECS*, SPECINFO, TOXCENTER, ULIDAT, USPAT2, USPATFULL (*File contains numerically searchable property data) Other Sources: DSL**, EINECS**, TSCA** (**Enter CHEMLIST File for up-to-date regulatory information) CODE| VALUE | CONDITION | TYPE |NOTE ====+==================+================+==========+==== HVAP|73560+/-3000 J/mol|Press: Pa|Predicted |(1)

224 224 Have there been any reports on the use of Cs complex with the following molecule as component of polymerization catalyst? How many reports on NMR studies of these complexes?

225 225 => 2/nrrs(s)c n o/relf(s)2 n/rel(s)6 o/rel(s)18 c/rel and ring parent/ci L1 7 2/NRRS(S)C N O/RELF(S)2 N/REL(S)6 O/REL(S)18 C/REL AND RING PARENT/CI

226 226 => l1 and c12n2o4-c12n2o4/ea 164 C12N2O4-C12N2O4/EA L2 1 L1 AND C12N2O4-C12N2O4/EA => d rn mf str rsd

227 227 RN MF C18H36N2O6

228 228 Ring System Data Elemental| Elemental | Size of |Ring System| Ring | RID Analysis | Sequence |the Rings| Formula | Identif. | Occurr. EA | ES | SZ | RF | RID | Count =========+=============+=========+===========+==========+======== C12N2O4- |NC2OC2OC2NC2O|18-18 |C18N2O6 | |1 C12N2O4 |C2OC2- | | | | |NC2OC2OC2NC2O| | | | |C2OC2

229 229 => c cs n o/relf(s)18 c/rel(s)2 n/rel(s)6 o/rel(s)nrrs>=2 L1 15 => l1 and nmr spectra/spec L2 0 L1 AND NMR SPECTRA/SPEC

230 230

231 231 => /rid L /RID => fil caplus => l1 L4 43 L1 => l4 and (polym? or oligomer?) L5 1 L4 AND (POLYM? OR OLIGOMER?)

232 232 => l3/d(l)(cs or ces? or group(w)(I or Ia) or alkal?(2a)earth?) L6 23 L3/D(L)(CS OR => l6 and (?polym? or oligom? or catal?) L7 0 L6 AND => (l4 or l6)(l)nmr L8 10 (L4 OR L6)(L)NMR


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