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1 Advanced Tools in Searching Patents. 2 Searching Generic Groups (Element Count)

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Presentation on theme: "1 Advanced Tools in Searching Patents. 2 Searching Generic Groups (Element Count)"— Presentation transcript:

1 1 Advanced Tools in Searching Patents

2 2 Searching Generic Groups (Element Count)

3 3 Hy Example: Hy with an element count of : N = maximum of 2 S = 0 C = At least 4 For search purposes, element counts are also generated for real atom portions of the query: Example: The following isolated ring has these generated element counts: C = exactly 3 and O = exactly 2: Searching Generic Groups

4 4 The string generated in Marpat for this structure is: Hy Searching Generic Groups Element Count The symbols between are the Element Count

5 5 Hy Searching, in Marpat, the previous structure, will the following heterocycle be found? At Match Level Atom: At Match Level Class: No Yes Searching Generic Groups

6 6 A generic group set to match level class with assigned generic attributes, e.g., Assigned generic attributes for Cb: <7C SATURATED MONOCYCLIC Real atom carbocyclic rings matching the assigned generic attributes, e.g., cyclohexyl, cyclopropyl, etc. Cb with any specification that matches <7 C SATURATED MONOCYCLIC Example: Cb Cb with >6C UNSATURATED POLYCYCLIC would not be retrieved Example: CB Searching Generic Groups

7 7 Match level : 1:Atom 2:Atom 3:Atom 4:Atom 5:Atom Generic attributes : 4: Saturation : Saturated Number of Carbon Atoms : less than 7 Type of Ring System : MonocyclicLMARPAT

8 8 Match level : 1:CLASS 2:CLASS 3:CLASS 4:CLASS 5:CLASS Generic attributes : 4: Saturation : Saturated Number of Carbon Atoms : less than 7 Type of Ring System : MonocyclicLMARPAT

9 9 Only Class Results G1 = hydrocarbyl G2 = cycloalkyl G6 = cycloalkyl G4 = Cb (SO) G2 = alkyl (SR (1-) cycloalkyl G13 = cycloalkyl

10 10 If the query contains Retrievals include the following: A specific heterocyclic ring that is isolated and set to match level class: Pyridine ring Hy with any specification that matches < 7 C * UNSATURATED MONOCYCLIC must be considered the option N 1Q *(must be considered the option N) Example: Hy Hy with >6C SATURATED POLYCYCLIC >1Q would not be retrieved Example: Hy Searching Generic Groups

11 11 Match level : 1:Class 2:Class 3:Class 4:Class 5:Class 6:Class 7:Class 8:Class 1:Class 2:Class 3:Class 4:Class 5:Class 6:Class 7:Class 8:Class 30 SEA SSS FUL L1 LMARPAT

12 12 Match level : 1:Atom 2:Atom 3:Atom 4:Atom 5:Atom 6:Atom 7:Atom 8:Atom 17 SEA SUB=L3 SSS FUL L4 LMARPAT

13 13 Only Class Results (1-2) N G7 = Hy (SO (1-) G8) (1-) N G1 = Hy (0-) N G3 = Hy (SO (-3) G4) G14 = Hy (SO) (1-) N G3 = Hy (SO (1-) G7) (1-) N G4 = heteroaryl (SR (1-) G5) (1-4) N G1 = Hy (SO (1-) G2)

14 14 Generic group element counts Element counts specify the elements that must be present (or absent). Other elements not explicitly defined may also be present if the generic group definition allows for them. Element counts may be assigned to the generic groups Ak, Cy, Cb, Hy in query structures to improve the precision of the search. Searching Generic Groups

15 15 The type of substances retrieved with element counts is determined by the match level assignments: At match level atom, element counts match:  Real atom structures that meet exactly the criteria Searching Generic Groups

16 16 Searching Generic Groups At match level Class, element counts may match:  Real atom structures that meet the criteria  Generic group with additional attributes, if the attributes match the element counts in the query attributes match the element counts in the query

17 17 Structure versus Generic group search at atom level (LMARPAT)

18 18 Match level : 1:Atom 2:Atom 3:Atom 4:Atom 5:Atom 6:Atom 7:Atom 8:Atom isolated ring systems : containing 1 17 SEA SSS FUL

19 19 Match level : 1:Atom 2:Atom 3:Atom Generic attributes : 1: Saturation : Unsaturated Number of Carbon Atoms : less than 7 Number of Hetero Atoms : Exactly 1 Type of Ring System : Monocyclic Type of Ring System : Monocyclic Element Count : Node 1: Limited N,N1 N,N1 C,C5 C,C5 24 SEA SSS FUL

20 20 7 more answers in LMARPAT due to Generic Group search G1 = / / / G6 = O Why this answer was not retrieved in the structure search? For the position of O, it is in meta not in para.

21 21 Structure versus Generic group search at class level (LMARPAT)

22 22 Match level : 1:CLASS 2:CLASS 3:CLASS 4:CLASS 5:CLASS 6:CLASS 7:CLASS 8:CLASS isolated ring systems : containing 1 30 SEA SSS FUL

23 23 Match level : 1:CLASS 2:CLASS 3:CLASS Generic attributes :1: Saturation : Unsaturated Number of Carbon Atoms : less than 7 Number of Hetero Atoms : Exactly 1 Type of Ring System : Monocyclic Type of Ring System : Monocyclic Element Count : Node 1: Limited C,C5 C,C5 N,N1 N,N1 36 SEA SSS FUL

24 24 The answers retreived in the Generic Group and not in the Structure search,at class level, are essentially due to the same reason as atom level

25 25 Case Study (Class-Limited) Find patents in Marpat on the following structure. Rings are isolated. Have you found the EP313874?

26 26 Case Study (Class-Limited) => fil caplus => EP313874/pn L1 1 EP313874/PN => fil marpat L2 HAS NO ANSWERS

27 27 Case Study (Class-Limited) => l2 full L4 41 SEA SSS FUL L2 => l1 and l4 1 L1 L5 0 L1 AND L4

28 28 Element Count Match Level  Limited  Unlimited Searching Generic Groups

29 29 Limited class level Limited is the default value assigned to the entire query structure. Limited affects how real atoms and generic groups with element counts match the MARPAT structures. Limited restricts retrieval at the class level to: Limited has no effect on atom matches. Searching Generic Groups  Real atom structures that match the query attributes that match the query element counts  Generic groups with additional attributes that match the query element counts

30 30 NOTE: Match Level CLASS NOTE: The "Limited" check box specifies how element counts will match candidate generic groups with Match Level CLASS. When checked, only generic groups with assigned element counts that match those in the query structure are retrieved. For best precision, "Limited" should be checked. "Limited" on the circled part of the structure will retrieve: Benzopyran real atom structure Hy Searching Generic Groups

31 31 A generic group set to match level class with assigned generic attributes, e.g., Assigned generic attributes for Cb: SATURATED MONOCYCLIC Assigned element count for Cb: 6-10 C With match level limited: Real atom carbocyclic rings matching the assigned generic attributes, e.g., cyclohexyl, cyclooctyl, etc. Cb with any specification that matches: SATURATED MONOCYCLIC 6-10 C Example: Cb Without match level limited: Previous ones Cb with no further qualification

32 32 A specific heterocyclic ring that is isolated and set to match level class, e.g., With EC match level limited: Pyridine ring Hy with any specification that matches: UNSATURATED MONOCYCLIC E5 C E1 N Examples: Hy Hy Without EC match level limited: Previous ones Hy with no further qualification Hy with any specification that matches Hy with any specification that matches: <7 C UNSATURATED MONOCYCLIC 1Q Examples: Hy Hy

33 33 Match level : 1:Atom 2:Atom 3:Atom 4:Atom 5:Atom 6:Atom 7:Atom 8:Atom 17 SEA SSS FUL Search in Lmarpat at Match Level Atom Limited

34 34 Match level : 1:Atom 2:Atom 3:Atom 4:Atom 5:Atom 6:Atom 7:Atom 8:Atom 17 SEA SSS FUL Search in Lmarpat at Match Level Atom Unlimited

35 35 Match level : 1:CLASS 2:CLASS 3:CLASS 4:CLASS 5:CLASS 6:CLASS 7:CLASS 8:CLASS 30 SEA SSS FUL Search in Lmarpat at Match Level Class Limited

36 36 Match level : 1:CLASS 2:CLASS 3:CLASS 4:CLASS 5:CLASS 6:CLASS 7:CLASS 8:CLASS 50 SEA SSS FUL Search in Lmarpat at Match Level Class Unlimited

37 37 (1-2) N G7 = Hy (SO (1-) G8) (1-) N G1 = Hy (SO (1-) G2) (0-) N G3 = Hy (SO (-3) G4) (1-) N G14 = Hy (SO) / (1-) N G3 = Hy (SO (1-) G7) (1-) N G4 = heteroaryl (SR (1-) G5) / (1-4) N G1 = Hy (SO (1-) G2) / (1-) N G9 = Hy (SO (1-) G5) / (0-) N G1 = heteroarylene (SO (1-) G2) (0-)N G1 = heteroaryl (SO (1-) G4) / (-2) N G8 = Hy (SO (1-) G9) / (0-) N G17 = Hy (SO (1-) G18) / (0-) N G9 = Hy (SO (1-) G10) / Due to Match Level Class Limited

38 38 1) G9 = Hy 2) G3 = heteroaryl (SO (1-) G2) Due to Match Level Class Unlimited 3) G3 = ) G1 = heteroaryl (SR (1-) G2) Hy (SO (1-) G5) 5) G3 = Hy (SO (1-) G5) pyridyl 6) G3 = Hy (SO (1-) G2) / (SC thienyl / pyridyl)

39 39 7) G2 = Hy 8) G1 = heteroaryloxy (SO (1-) G4) 9) G1 = Hy (SO (1-) G5) 10) G1 = heteroaryl (SO (1-) G2) 11) G3 = Cy (SO (1-) G12) 12) G7 = heteroaryl (SO (1-) G8) 13) G3 = heteroaryl (SO (1-) G2) 14) G1 = heteroaryl (SO (1-) alkyl) 15) G1 = heteroaryl (SR (1-2) G2 16) G2 = heteroaryloxy (SO (1-) G3) 17) G2 = heteroaryloxy (SO (1-) G3) 18) G1 = heteroaryl (SO (1-) G2) 19) G8 = Hy (SO (1-) G7) 20) G8 = Ak (SO) / Cy (SO) Due to Match Level Class Unlimited

40 40 Search in Lmarpat at Match Level Class Limited Match level : 1:CLASS 2:CLASS 3:CLASS Generic attributes : 1: Saturation : Unsaturated Number of Carbon Atoms : less than 7 Number of Hetero Atoms : Exactly 1 Element Count : Node 1: Limited C,C5 N,N1 36 SEA SSS FUL

41 41 Search in Lmarpat at Match Level Class Unlimited Match level : 1:CLASS 2:CLASS 3:CLASS Generic attributes : 1: Saturation : Unsaturated Number of Carbon Atoms : less than 7 Number of Hetero Atoms : Exactly 1 Element Count : Node 1: Limited C,C5 N,N1 56 SEA SSS FUL

42 42 SUMMARY Element Count (Limited, Unlimited)

43 43 Generic attributes :1 Saturation: Unsaturated N°of Carbon Atoms : less than 7 N°of Hetero Atoms : Exactly 1 Element Count:Node 1:C,C5 N,N1 1) Atom 17 answers 2) Class Limited 30 answers 3) Class Unlimited 49 answers 1) Atom 24 answers 2) Class Limited 36 answers 3) Class Unlimited 56 answers Group A Group B

44 44 Differences between Goup A and Group B Class Limited AN 111: AN 110: AN 110: AN 110:57406 AN 109: AN 108: Atom AN 111: AN 111: AN 110: AN 110: AN 110:57406 AN 109: AN 108: Class Unlimited AN 112:35299 AN 111: AN 110: AN 110: AN 110:57406 AN 109: AN 108:167322

45 45 The difference between the two groups is almost costant. Six, of seven, are generated at Atom level Then it is better, if possible, searching Marpat, to use Generic Groups with element count, instead of drawing a structure.

46 46 Limited or Unlimited has no effect on Generic Groups definitions

47 47 Match level : 1:CLASS 2:CLASS 3:CLASS Generic attributes : 1: Saturation : Unsaturated Number of Carbon Atoms : less than 7 Number of Hetero Atoms : Exactly 1 LIMITED 73 SEA SSS FUL Match level : 1:CLASS 2:CLASS 3:CLASS Generic attributes : 1: Saturation : Unsaturated Number of Carbon Atoms : less than 7 Number of Hetero Atoms : Exactly 1 UNLIMITED 73 SEA SSS FUL

48 48 Due to the last search The difference between this last searches and n°3, Group B, (Hy class unlimited), is:17 16 of 17 are again generated at Atom level, and always N is absent

49 49 Match level : (Limited or Unlimited) 1:CLASS 2:CLASS 3:CLASS (Limited or Unlimited) 161 SEA SSS FUL Search in Lmarpat at Match Level Class

50 50 Conclusions It seems that when you have an element count, in any way, the system creates a population on this basis. Then it extends the search, passing from Atom, to Class Limited, and to Class Unlimited, but the population is always the same. Searching in Marpat you should put your structure always at: CLASS, UNLIMITED

51 51 Find patents in Marpat on the following structure. Rings are isolated. Have you found the EP313874? Case Study (Class-Unlimited)

52 52 Case Study (Class-Unlimited) => fil caplus => EP313874/pn L1 1 EP313874/PN => fil marpat L2 HAS NO ANSWERS

53 53 Case Study (Class-Unlimited) => l2 full L4 198 SEA SSS FUL L2 => l1 and l4 1 L1 L5 1 L1 AND L4 => d fhit heterocycle G8 =....heterocycle

54 54 Query Atom Class L Class U Hy Write a correct string for each level

55 55 Hy Yes No Yes No Yes Searching at Level Class Limited with the following string: Which of the following structures are retreived?

56 56 Query Atom Class L Class U Hy Write a correct string for each level QQ

57 57 Precision Tools If you draw in your query a specific group (i.e. pyridine), also at Class Level, you find only Generic Groups which specifically encompass your designed group (i.e. … a heterocycle with 1 N …) at Match Level Class Limited. You find also Generic Groups with no definitions if you use, for pyridine ring, the Match Level Class Unlimited. But you always miss all structures for which pyridine is not allowed But you always miss all structures for which pyridine is not allowed.

58 58 Ak Hy X Cy Precision Tools

59 59 Hy* limited finds Hys which encompass specifically the pyridine ring Hy* unlimited finds also Hy or Cy without specifications Precision Tools (Class Level)

60 60 Searching Structures in Marpat (connected) SEA SSS FUL

61 61 Searching Structures in Marpat (connected) pyridyl G1 =... pyridyl heteroaryl G4 =.. heteroaryl

62 62 Searching Structures in Marpat (disconnected) => fil lmarpat 106 SEA SSS FUL

63 63 68 G1 = 13 / 19 / 68 alkyl G4 =... alkyl alkyl G8 =...alkyl Searching Structures in Marpat (disconnected)

64 64 System Limits

65 65 System Limits

66 66 Large Queries There is a limit on the size of the query that STN can search. This may happen if the structure query contains:  Variable groups with many repetitions.  Many G-groups with many definitions. System Limits

67 67 System Limits

68 68 System Limits

69 69 Structures with Invalid Ring/Chain Bonds  Ring/chain nodes may be used in MARPAT queries;  Ring/chain bonds may not. System Limits

70 70 Marpat, CAPlus, Registry

71 71 In this examples we analyze the interactions among the Files:  REGISTRY  (H)CAPLUS  MARPAT Marpat, CAPlus, Registry

72 72 Registry CAPlus Marpat The basic starting point of this kind of searches is that also in patents containing Markush structures, at least one example with a compound must be present

73 73 Registry CAPlus Marpat I.Then you can collect in Registry a broad class of compounds focused on the main structural aspects reported in the examplified compound. II.Search this set in CAPlus (up to RNs in one item) and isolate the patents present in Marpat. III.That patents set is the subset on which run a broad substructure search in Marpat (you can transfer up to patents in one item)

74 74 Find patents in Marpat on the following structure. Rings are isolated. Find the EP Case Study (Reg-CA-Marpat)

75 75 Case Study (Reg-CA-Marpat) Searching this structure at level class limited, in Marpat, you get 41 patents and EP is not present.

76 76 Case Study (Reg-CA-Marpat) Searching this structure at level class unlimited, in Marpat, you get 198 patents and EP is present.

77 77 Case Study (Reg-CA-Marpat) => fil reg => (c6-c10/ea or c6-c9/ea or c6-c8/ea or c5-c10/ea or c5-c9/ea or c5-c8/ea) L (C6-C10/EA OR C6-C9/EA OR C6-C8/EA OR C5-C10/EA OR..... You can collect in Registry a broad class of compounds focused on the main structural aspects reported in the examplified compound

78 78 Case Study (Reg-CA-Marpat) Search this set in CAPlus (up to RNs in one item) and isolate the patents present in Marpat. => fil caplus => EP313874/pn L2 1 EP313874/PN => l1 and marpat/os L3 79 L1 AND MARPAT/OS

79 79 Case Study (Reg-CA-Marpat) That patents set is the subset on which run a broad substructure search in Marpat (you can transfer up to patents in one item) => fil marpat => fil marpat => l3 L4 79 L3 L4 79 L3 => Uploading C:\STNEXP\Queries\registrycaplusmarpat.str L5 STRUCTURE UPLOADED

80 80 Case Study (Reg-CA-Marpat) That patents set is the subset on which run a broad substructure search in Marpat (you can transfer up to patents in one item) Class Level Unlimited

81 81 Case Study (Reg-CA-Marpat) That patents set is the subset on which run a broad substructure search in Marpat (you can transfer up to patents in one item) => l5 full subset=l4 L7 13 SEA SUB=L4 SSS FUL L5 => fil caplus => l2 and l7 L8 1 L2 AND L7

82 82 Search Question: Find patents claiming the use of the Zr complexes. These complexes are used in olefines polymerization. Case Study (Reg-CA-Marpat)

83 83 => fil reg => zr/rel L ZR/REL => b4/pg L B4/PG => l2 and ti/els L L2 AND TI/ELS => l2 not l3 L L2 NOT L3 Case Study (Reg-CA-Marpat)

84 84 => fil caplus => l1(l)(?olefi? or ?ethen? or ?ethyle? or ?propyle? or ?propen?)(l)?polym? L L1(L)(?OLEFI? OR ?ETHEN? OR ?ETHYLE? OR.. => l5 and p/dt L L5 AND P/DT Case Study (Reg-CA-Marpat)

85 85 => l3 and marpat/os L L3 AND MARPAT/OS => l4 and marpat/os L L4 AND MARPAT/OS => fil marpat => l7 or l8 L L7 OR L8 Case Study (Reg-CA-Marpat)

86 86 => Uploading C:\STNEXP\Queries\Zr1.str ring nodes : ring bonds : exact/norm bonds : Match level : 1:CLASS 2:CLASS 3:CLASS UNLIMITED L10 STRUCTURE UPLOADED => l10 full subset=l9 L SEA SUB=L9 SSS FUL L10 Case Study (Reg-CA-Marpat)

87 87 => Uploading C:\STNEXP\Queries\Zr2.str chain nodes : 4 ring nodes : ring bonds : exact/norm bonds : Match level : 4:Atom 1:CLASS 2:CLASS 3:CLASS 4:Atom UNLIMITED L13 STRUCTURE UPLOADED => l13 full subset=l12 L SEA SUB=L12 SSS FUL L13 Case Study (Reg-CA-Marpat)

88 88 => fil caplus => l15 and (?olefi? or ?ethen? or ?ethyle? or ?propyle? or ?propen?)(l)?polym? L L15 AND (?OLEFI? OR ?ETHEN? OR... => l16 not l6 L L16 NOT L6 G14 = Ti / Zr / Hf Case Study (Reg-CA-Marpat)

89 89 Marpat, CAPlus, Registry (Marpat results analysis)

90 90 Search Question: Find patents claiming the use of the following Copper complexes as dyes. Case Study (Reg-CA-Marpat)

91 91 N ACu A NN N A A A = Any atom except Hydrogen The bonds are all undefined Case Study (Reg-CA-Marpat)

92 92 A very general search is run, using dictionary terms, in File Registry. Structures are searched containing:  Copper in a ring system  The ring system must have: 4 or more N C atoms 8 or more rings Case Study (Reg-CA-Marpat)

93 93 => cu/rel(s)>=4 n/rel(s)c/rel(s)nrrs=>8 L CU/REL(S)>=4 N/REL(S)C/REL (S)NRRS=>8 Case Study (Reg-CA-Marpat)

94 94 In File CAPlus are searched patents, concerning dyes, in which one or more of the previous structures are claimed. Case Study (Reg-CA-Marpat)

95 95 => fil caplus => l1 and dye? and p/dt L L1 AND DYE? AND P/DT Case Study (Reg-CA-Marpat)

96 96 => d hitstr Case Study (Reg-CA-Marpat)

97 97 Marpat is searched by structure (the only available). The search is done in two steps: 1) All the desired structures containing a complexed metal (Class level) are isolated. 2) On this set a refinement is done for Copper Case Study (Reg-CA-Marpat)

98 98 => fil marpat => Uploading C:\Program Files\Stnexp\Queries\k1.str L3 STRUCTURE UPLOADED Case Study (Reg-CA-Marpat)

99 99 Case Study (Reg-CA-Marpat)

100 100 Match level : 1:Atom 2:Atom 3:Atom 4:CLASS 6:Atom 7:Atom 8:Atom 9:Atom 10:Atom 11:Atom 12:Atom 13:Atom 14:Atom 15:Atom 16:Atom 17:Atom 18:Atom 19:Atom 20:Atom 21:Atom 22:Atom 23:Atom 24:Atom 25:Atom 26:Atom Case Study (Reg-CA-Marpat)

101 101 => l3 full L SEA SSS FUL L3 => Uploading C:\Program Files\Stnexp\Queries\k2.str L5 STRUCTURE UPLOADED Case Study (Reg-CA-Marpat)

102 102 Case Study (Reg-CA-Marpat)

103 103 chain nodes : 6 ring nodes : ring bonds : exact/norm bonds : Match level : 1:Atom,2:Atom,3:Atom,4:CLASS,6:Atom Case Study (Reg-CA-Marpat)

104 104 => l5 full subset=l4 L SEA SUB=L4 SSS FUL L5 => fil caplus => l6 and dye? L7 436 L6 AND DYE? => l7 not l2 L8 115 L7 NOT L2 Case Study (Marpat-CA-Reg)

105 105 At the end of this first part there are 115 patents, due to searching Marpat, on the matter of interest, and not retreived in Registry Caplus search. Marpat, CAPlus, Registry

106 106 At this point it is interesting to have a look at Markush structures, in Marpat, for which those 115 patents were selected. They all have the same kind of structures, as the following: Marpat, CAPlus, Registry

107 107 G5 = metal ion (+2) / 86 G7 = Cu / Zn / Mg / Co / Ni / Fe Marpat, CAPlus, Registry

108 108 The basic reason for missing those patents in Registry, CAPlus is: In the 115 patents the searched Cu complexes are claimed but not described. So there is no indexing for the searched RNs, coming from Registry, in CAPlus. Marpat, CAPlus, Registry

109 109 Now the first question is: Is it possible to isolate in the 115 set, patents describing the required complexes, but with metals not Cu? Marpat, CAPlus, Registry

110 110 Search for similar complexes Marpat, CAPlus, Registry

111 111 Summary of the previous search FILE 'REGISTRY' ENTERED L CU/REL(S)>=4 N/REL(S)C/REL(S)NRRS=>8 FILE 'CAPLUS' ENTERED L L1 AND DYE? AND P/DT FILE 'MARPAT' ENTERED L3 STR L SEA FILE=MARPAT SSS FUL L3 L7 STR L SEA FILE=MARPAT SUB=L4 SSS FUL L7 Marpat, CAPlus, Registry

112 112 => l8 and dye? L9 436 L8 AND DYE? => l9 not l2 L L9 NOT L2 => sel rn SmartSELECT INITIATED New TRANSFER and ANALYZE Commands Now Available See HELP TRANSFER and HELP ANALYZE for Details L11 SEL L10 1- RN : 1140 TERMS Marpat, CAPlus, Registry

113 113 => fil reg => l11 and m/rel(s)>=4 n/rel(s)c/rel(s)nrrs=>8 L L12 AND M/REL(S)>=4 N/REL(S)C/REL.. => fil caplus => l10 and l L13 L18 52 L10 AND L13 => l10 not l18 L19 63 L10 NOT L18 63 patents remaining Marpat, CAPlus, Registry

114 114 => d l18 hitstr... Marpat, CAPlus, Registry

115 115 Marpat, CAPlus, Registry

116 116 Marpat, CAPlus, Registry

117 117 Another question is: Is it possible that someone claimed the simultaneous presence of a metal and a ligand for making a dye? Not considering any pre-formed complex between metal and ligand? In order to analyze these points the next search starts from the last 63 patents set. Marpat, CAPlus, Registry

118 118 Search for derivatives Marpat, CAPlus, Registry

119 119 FILE 'CAPLUS' ENTERED L13 63 L8 NOT L12 => sel rn SmartSELECT INITIATED L14 SEL L13 1- RN : 624 TERMS Marpat, CAPlus, Registry

120 120 => fil reg => l14 and >=4 n/rel(s)c/rel(s)nrrs>=5 L18 35 L17 AND >=4 N/REL(S).... => l14 and m/els not (m/rel or (a1 or a2)/pg) L26 14 L25 AND M/ELS NOT (M/REL OR.. Searching for the ligand Searching for the metal Marpat, CAPlus, Registry

121 121 => fil caplus => l13 and l18 and l L L26 L27 2 L13 AND L18 AND L26 => l13 not l27 L28 61 L13 NOT L27 61 patents remaining Marpat, CAPlus, Registry

122 122 => d L27 hitstr 1-2 L27 ANSWER 1 OF 2 CAPLUS COPYRIGHT 2002 ACS IT D, Phthalocyanine, derivs D, Aluminum, phthalocyanine deriv. complexes, uses D, Scandium, phthalocyanine deriv. complexes, uses D, Titanium, phthalocyanine deriv. complexes, uses D, Gallium, phthalocyanine deriv. complexes, uses D, Zinc, phthalocyanine deriv. complexes, uses RN CAPLUS CN Aluminum (8CI, 9CI) (CA INDEX NAME) RN CAPLUS CN Scandium (8CI, 9CI) (CA INDEX NAME) Marpat, CAPlus, Registry

123 123 L27 ANSWER 2 OF 2 CAPLUS IT , Aluminum chloride, IT DP Marpat, CAPlus, Registry

124 124 The next search starts considering only the 61 remaining patents. Marpat, CAPlus, Registry

125 125 L28 61 L13 NOT L27 => sel rn SmartSELECT INITIATED New TRANSFER and ANALYZE Commands Now Available See HELP TRANSFER and HELP ANALYZE for Details L29 SEL L28 1- RN : 618 TERMS Marpat, CAPlus, Registry

126 126 => fil reg => l29 and >=4 n/rel(s)c/rel(s)nrrs>=5 L31 35 L30 AND >=4 N/REL(S)C/REL... => fil caplus => l28 and l31/d 2251 L31/D L33 6 L28 AND L31/D => l28 not l33 L35 55 L28 NOT L33 55 patents remaining Searching for the ligand Marpat, CAPlus, Registry

127 127 => d L33 hitstr l33... L33 ANSWER 1 OF 6 CAPLUS COPYRIGHT 2002 ACS IT DP,... Marpat, CAPlus, Registry

128 128 IT D, Phthalocyanine, derivs., metal complexes... Marpat, CAPlus, Registry

129 129 In these last two searches for derivatives only 8 patents have been found. But in other cases (i.e. complexes used as catalysts) this kind of searches collect many more results. Marpat, CAPlus, Registry

130 130 The last 55 have not any peculiar indexing. So it is not possible to look a bit in depth in the patents. But they have in Marpat the reported structure, because the searched complexes are mentioned in the patents. In the following slides one of the 55 is reported. Marpat, CAPlus, Registry

131 131 AB A reactive dye mixt. of at least 2 dyes comprises I (X1, X2 = H, SO3H; Y1, Y2 = vinyl or vinyl-generating group under alk. conditions) and at least one addnl. reactive dye selected from a monoazo pyrazole dye, a mono- or disazo dye, a monoazo pyridone dye, a monoazo naphthyl dye, a disazo aminonaphthyl dye, a formazan dye, an azo acetoacetanilide dye, an azobenzene-based disazo dye, a metal a naphthalimide or azo naphthalenetriazole dye, a metal phthalocyanine dye phthalocyanine dye, or a triphendioxazine dye. Incorporation of I improves the fastness of the dye mixt. Examples were given for dyeing of cotton. Marpat, CAPlus, Registry

132 132 IT Reactive dyes (reactive dye mixts. for application to cotton) IT Reactive dyeing (reactive dye mixts. for application to cotton in) IT Reactive azo dyes (vinyl sulfone; reactive dye mixts. for application to cotton) IT RL: TEM (Technical or engineered material use); USES (Uses) (dye; for reactive dyeing of cotton) IT RL: TEM (Technical or engineered material use); USES (Uses) (dye; in reactive dye mixts. for application to cotton) IT RL: TEM (Technical or engineered material use); USES (Uses) (navy blue mixt.; reactive dye mixts. for application to cotton) Marpat, CAPlus, Registry

133 133 Casreact Registry, CAPlus, Marpat

134 134 Search patents for the following reaction Casreact Registry, CAPlus, Marpat

135 135 Casreact Registry, CAPlus, Marpat

136 136 Casreact chain nodes : ring nodes : chain bonds : exact/norm bonds : exact bonds : fragments assigned product role: containing 9 fragments assigned reactant/reagent role: containing 1, containing 3 reaction site bonds: 1-2:CC 4-6:CC 9-10:CC node mappings: 1:9 5:11 Casreact Registry, CAPlus, Marpat

137 137 Casreact => fil casreact L1 STRUCTURE UPLOADED => l1 full L3 34 SEA SSS FUL L1 ( 204 REACTIONS) => l3 and p/dt P/DT L4 6 L3 AND P/DT (6 patents in Casreact) Casreact Registry, CAPlus, Marpat

138 138 Registry, CAPlus Strategy PREP/RL RCT/RL AND Casreact Registry, CAPlus, Marpat

139 139 Registry, CAPlus => fil reg => c5n/eas and nc=1 and nrs=>2 L C5N/EAS AND NC=1 AND NRS=>2 => Uploading C:\Program Files\stnexp\Queries\..... L2 STRUCTURE UPLOADED => d L2 HAS NO ANSWERS L2 STR Casreact Registry, CAPlus, Marpat

140 140 Registry, CAPlus => l2 full subset=l1 FULL SUBSET SEARCH INITIATED 10:50:17 FULL SUBSET SCREEN SEARCH COMPLETED TO ITERATE 100.0% PROCESSED ITERATIONS 1323 ANSWERS SEARCH TIME: L SEA SUB=L1 SSS FUL L2 (product) Casreact Registry, CAPlus, Marpat

141 141 Registry, CAPlus => fil reg => c5n/eas and nc=1 and nrs=1 and c<19 L C5N/EAS AND NC=1 AND NRS=1 AND C<19 => Uploading C:\Program Files\stnexp\Queries\..... Connectivity : 1:2 E exact RC ring/chain 2:2 M minimum RC ring/chain 3:2 E exact RC ring/chain 4:2 E exact RC ring/chain 6:2 E exact RC ring/chain Casreact Registry, CAPlus, Marpat

142 142 Registry, CAPlus => l2 full subset=l1 FULL SUBSET SEARCH INITIATED 14:35:07 FULL SUBSET SCREEN SEARCH COMPLETED TO ITERATE 100.0% PROCESSED ITERATIONS 1933 ANSWERS SEARCH TIME: L SEA SUB=L1 SSS FUL L2 (reactant 1) => l2 sample subset=l1 PROJECTIONS (WITHIN SPECIFIED SUBSET):ONLINE **INCOMPLETE** PROJECT ITERATIONS (WITHIN SPECIFIED SUBSET): TO PROJECT ANSWERS (WITHIN SPECIFIED SUBSET): 1704 TO 3006 L3 6 SEA SUB=L1 SSS SAM L2 Casreact Registry, CAPlus, Marpat

143 143 Registry, CAPlus => fil reg => c6/eas and nc=1 and nrs=1 and c<=25 and 1-3/o L C6/EAS AND NC=1 AND NRS=1 AND C<=25 AND 1-3/O Casreact Registry, CAPlus, Marpat

144 144 Registry, CAPlus Connectivity : 9:1 E exact RC ring/chain Match level : 1:Atom 2:Atom 3:Atom 4:Atom 5:Atom 6:Atom 7:CLASS 8:CLASS 9:CLASS L2 STRUCTURE UPLOADED => l2 full subset=l1 L SEA SUB=L1 SSS FUL L2 (reactant 2) Casreact Registry, CAPlus, Marpat

145 145 Registry, CAPlus => fil caplus => l11/prep and l7/rct and l4/rct and p/dt L12 7 L11/PREP AND L7/RCT AND L4/RCT AND P/DT (7 patents in Registry-CAPLus) Casreact Registry, CAPlus, Marpat

146 146 Marpat, Registry, CAPlus Strategy CLASS RCT/RL AND Casreact Registry, CAPlus, Marpat

147 147 Marpat, Registry, CAPlus Strategy Match level : 1:CLASS 2:CLASS 3:CLASS 4:CLASS 5:CLASS 6:CLASS 7:CLASS 8:CLASS 9:CLASS 10:CLASS 11:CLASS 12:CLASS 13:CLASS 14:CLASS L1 STRUCTURE UPLOADED Casreact Registry, CAPlus, Marpat

148 148 => l1 FULL FILE PROJECTIONS: ONLINE **INCOMPLETE** BATCH **COMPLETE** PROJECTED ITERATIONS: TO PROJECTED ANSWERS: 1399 TO 2595 L2 23 SEA SSS SAM L1 => batch ENTER QUERY L# FOR BATCH REQUEST OR (END):l1 fedipromar/b ENTER BATCH REQUEST NAME OR (END):fedipromar/b ENTER TYPE OF SEARCH (SSS) OR CSS:. ENTER SCOPE OF SEARCH (FULL) OR RANGE:. QUERY L1 HAS BEEN SAVED AS BATCH REQUEST 'FEDIPROMAR/B' Marpat, Registry, CAPlus Strategy Casreact Registry, CAPlus, Marpat

149 149 Marpat, Registry, CAPlus Strategy => fil marpat => d sav NAME CREATED NOTES/TITLE FEDIPROMAR/A FEDIPROMAR/A 02 OCT ANSWERS IN FILE MARPAT => act fedipromar/a L1 STR L SEA FILE=MARPAT SSS FUL L1 => fil caplus => l2 L L2 => l14 and (l5/rct and l8/rct) L24 36 L14 AND (L5/RCT AND L8/RCT) (36 patents in Marpat-Registry-CAPLus) Casreact Registry, CAPlus, Marpat

150 150 Only from Marpat 32 patents TI Preparation of 2,4-pyrimidinediamines as IgE and/or IgG receptor modulators for treatment of allergic diseases, inflammatory conditions, and tissue destruction IT , 3-Methylcarbonylaniline , Piperidine, reactions RL: RCT (Reactant); RN CAPLUS CN Ethanone, 1-(3-aminophenyl)- (9CI) (CA INDEX NAME) RN CAPLUS CN Piperidine (7CI, 8CI, 9CI) (CA INDEX NAME) Casreact Registry, CAPlus, Marpat

151 151 Only from CAPLus 3 patents TI Preparation and effect of triazaspiro[5.5]undecane derivatives as active ingredients in remedy for inflammatory diseases IT P RL: PREP (Preparation); IT RL: RCT (Reactant) IT RL: RCT (Reactant) Casreact Registry, CAPlus, Marpat

152 152 Only from CASREACT 5 patents Casreact Registry, CAPlus, Marpat

153 153 Derwent Chemistry Resource

154 154 Derwent Chemistry Resource Specific compound registry for DWPI –Chemical structure and related substance data –Greater ease-of-use for chemical searchers –DCR Numbers link to DWPI (subscribers and not)

155 155 DCR Coverage B,C,E Basic Patents Derwent Update onwards Japan not included Derwent Chemistry Resource

156 156 Online availability Fully functional and seamless on STN Structures included on Questel.Orbit Available through Dialog-Link Available to all Derwent Users Seamless segment of WPIDS, WPINDEX and WPIX Derwent Chemistry Resource

157 157 Why use DCR? Unique answers in comparison to CAS Supplement your CAS Registry search with extra DCR answers Current awareness SDIs Derwent Chemistry Resource

158 158 DCR Record

159 159 DCR Number is the link to DWPI“Derwent Compound Number” is the compound number for this substance Chemical structures are searchable in STN-CAS format Synonyms

160 160 Crossover to DWPI 1. Search in DCR - e.g. by Compound name 3. Display the DWPI records - DCR Numbers are indexed in the KW field 2. Crossover from DCR to DWPI - to retrieve patent records

161 161 Derwent Chemistry Resource Number Format: figure sequential number 00 First suffix for stereisomers 00 Second suffix for salts 00 Third suffix for other cases (isotopes,....)

162 162 => 465-?/dcse L ?/DCSE => d dcse str 1-5

163 163 0 DCSE

164 DCSE

165 165 => ?/dcse L ?/DCSE => d 1,2 dcse str

166 166 6 DCSE Cl CM 1 Cl CM 2

167 167 5 DCSE Br CM 1 Br CM 2

168 168 List of Search fields...

169 169

170 170 Related DWPI Search fields...

171 171

172 172 Display Formats...

173 173

174 174 Structure Searching Use STN Express Standard query format Access WPINDEX, WPIDS or WPIX Upload structure query Search the query in DCR Crossover the DCR hits to DWPI

175 175 Search Options –Substructure (Sample) –Substructure (SSS) –Closed Substructure (CSS) –Family (FAM) –Exact (EXA) SSS Sample is the default Structure Searching

176 176 Prepare the structure query using “Standard Format” in STN Express

177 177 => file wpindex => Uploading C:\...\Stnexp\Queries\quinoline.str L1 STRUCTURE UPLOADED => d L1 HAS NO ANSWERS L1 STR

178 178 => l1 SAMPLE SEARCH INITIATED 11:55:54 SAMPLE SCREEN SEARCH COMPLETED TO ITERATE 100.0% PROCESSED 786 ITERATIONS INCOMPLETE SEARCH (SYSTEM LIMIT EXCEEDED) SEARCH TIME: FULL FILE PROJECTIONS: ONLINE **COMPLETE** BATCH **COMPLETE** PROJECTED ITERATIONS: 7032 TO 8688 PROJECTED ANSWERS: 3461 TO 4659 L2 50 SEA SSS SAM L1

179 179 => l1 full FULL SEARCH INITIATED 11:56:21 FULL SCREEN SEARCH COMPLETED TO ITERATE 100.0% PROCESSED 7074 ITERATIONS SEARCH TIME: L SEA SSS FUL L1

180 180 => d 10 all L3 ANSWER 10 OF 3130 WPINDEX (C) 2002 THOMSON AN.S DCR DCSE DCSE CN.S 7-[2-Cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3- yl]-3,5-dihydroxy-hept-6-enoic acid isopropyl ester

181 181 MF C28 H30 F N O4 SMF C28 H30 F N O4 *1; TOTAL *1; TYPE *1 MW SDCN RA6NTK SMIL CC(C)OC(=O)CC(O)CC(O)C=Cc1c(nc2ccccc2c1c3ccc(F)cc3)C4CC4 ISMI CC(C)OC(=O)CC(O)CC(O)/C=C/c1c(nc2ccccc2c1c3ccc(F)cc3)C4CC4 Derwent Compond Number in Derwent Chemistry Resource (DCR)

182 182 => d 1000 all L3 ANSWER 1000 OF 3130 WPINDEX AN.S DCR DCSE CM 1 Cl CM 2 Derwent Chemistry Resource Number

183 183 C20 H22 N4 O5 S. H Cl MF C20 H22 N4 O5 S. H Cl SMF C20 H22 N4 O5 S *1; H Cl *1; TOTAL *2; TYPE *2 MW SDCN RA4M2X SMIL Cl.Cc1cc(OCCCONC(=N)N)cc(OS(=O)(=O)c2cccc3cccnc23)c1 ISMI Cl.Cc1cc(OCCCONC(=N)N)cc(OS(=O)(=O)c2cccc3cccnc23)c1

184 184 => C20 H22 N4 O5 S. H Cl/mf L1 1 C20 H22 N4 O5 S. H CL/MF => C20 H22 N4 O5 S. Cl H/mf L2 0 C20 H22 N4 O5 S. CL H/MF => d l1 all L1 ANSWER 1 OF 1 WPINDEX (C) 2002 THOMSON DERWENT AN.S DCR DCSE

185 185 => fil reg => C20 H22 N4 O5 S. Cl H/mf L1 3 C20 H22 N4 O5 S. CL H/MF => C20 H22 N4 O5 S. H Cl/mf L2 0 C20 H22 N4 O5 S. H CL/MF => d l1 1-3 RN REGISTRY CN 8-Quinolinesulfonic acid, 3-[3- [[(aminoiminomethyl)amino]oxy]propoxy]-5- methylphenyl ester, monohydrochloride (9CI) C20 H22 N4 O5 S. Cl H MF C20 H22 N4 O5 S. Cl H

186 186

187 187 Chemical Name Fields  CN Chemical Name (Preferred and Synonym)  CN.P Chemical Name, Preferred  SY Synonym Name  CN.S Chemical Name, Systematic  CNS Chemical Name Segments (CN.S, CN.P, SY)

188 188 Indexing of Chemical Name Fields  CN Phrase (Preferred and Synonyms)  CN.P Phrase  SY Phrase  CN.S Phrase  CNS Words (CN.S, CN.P, SY)

189 189 Substance Descriptor Keywords related to classes of compounds. - Searchable in /CC field. - On Line help: HELP SDC

190 190 Substance Descriptor => e a/cc **** START OF FIELD **** E3 0 --> A/CC E4 735 ALKALOIDS/CC E5 50 ALLOYS/CC E6 163 ANTHRACYCLINES/CC E7 16 ANTIBODIES/CC E8 273 BARBITURATES/CC E9 899 BENZODIAZEPINES/CC E BETA LACTAMS/CC E11 12 BORANES/CC E CARBOHYDRATES/CC

191 191 Substance Descriptor => help sdc DCR Substance Descriptors (CC field) The Substance Descriptors are keywords that relate to classes of compounds, they are designed for retrieving groups of substances which are difficult, or impossible, to retrieve using a structure query, e.g. general Alkaloids.....

192 192 Searching Chemical Name => fil wpindex => bisphenol a/cn L1 1 BISPHENOL A/CN => d all

193 193 L1 ANSWER 1 OF 1 WPINDEX (C) 2002 THOMSON DERWENT AN.S DCR-9523 DCSE CN.P BISPHENOL-A BISPHENOL A SY 4,4'-DIHYDROXYDIPHENYL-2,2-PROPANE; BISPHENOL A; BISPHENOL-A

194 194 MF C15 H16 O2 SMF C15 H16 O2 *1; TOTAL *1; TYPE *1 MW SDCN R00470 SDRN 0470 SMIL CC(C)(c1ccc(O)cc1)c2ccc(O)cc2 ISMI CC(C)(c1ccc(O)cc1)c2ccc(O)cc2

195 195 => l1/dcr L2 179 L1/DCR => d l2 kwic L2 ANSWER 1 OF 179 WPINDEX (C) 2002 THOMSON DERWENT KW [1] CL PRD; CL PRD; CL; CL; CL; CL; CL; CL; CL; => d l2 179 an L2 ANSWER 179 OF 179 WPINDEX (C) 2002 THOMSON DERWENT [25] AN [25]

196 196 => help roles DERWENT COMPOUND NUMBER ROLES File WPINDEX incoporates two separate searchable compound numbering systems*: 1. Derwent Chemistry Resource Numbers (DCRE, 1999-date) 2. Derwent Compound Numbers (DCN, 1987-date) Each numbering system is searchable with Role Qualifiers to help narrow a search to particular kinds of references to a given compound

197 Derwent Chemistry Resource Number (DCRE) Roles The DCRE field does not include Roles. DCR numbers are indexed separately in the Keyword Indexing (KW) field with their Roles. DCR Roles can be searched on their own, or linked with DCR Numbers ONLY in the KW field. The (T) proximity operator is used to link Roles to DCR Numbers, e.g. => S ( (T)PRD)/KW => S L2/DCR(T)NEW/KW. See HELP DCR for further background information. The following DCR roles are available from 1999 onwards.

198 198 Role Definition Scope Notes CL CLAIM Applied to compounds present in the claim(s) or to compounds present in other parts of the patent document which specifically exemplify the patent claim(s). NEW NEW Substance, process, or apparatus claimed or described as new. PRD PRODUCED Production or manufacture of substance or apparatus is claimed or described. USE USE Use of substance or apparatus is claimed or described. DET DETECTED Applied to the keyword for a con- dition or substance which has been detected as a result of testing. ST SALT

199 199 KW KW [1] CL PRD; Also Inside DCR Field? Inside KW Field

200 200 => fil wpindex => ( (t)cl)/kw /KW CL/KW L2 249 ( (T)CL)/KW => /dcr(t)prd/kw /DCR PRD/KW L /DCR(T)PRD/KW

201 201 => flunitrazepam/cn L4 1 FLUNITRAZEPAM/CN L4 ANSWER 1 OF 1 WPINDEX (C) 2003 THOMSON DERWENT AN.S DCR DCSE CN.P FLUNITRAZEPAM => l4/dcr L5 14 L4/DCR L5 ANSWER 1 OF 14 WPINDEX (C) 2003 THOMSON DERWENT KW [1] CL USE; CL USE

202 202 => sel l4 dcse L9 SEL L4 1- DCSE : 1 TERM => d L9 SEL L4 1- DCSE : 1 TERM TERM # # OCC # DOC % DOC DCSE ********* END OF L9 *** => l9/dcr L10 0 L9/DCR

203 203 => e 9523/dcr **** START OF FIELD **** E > 9523/DCR E DCR-1/DCR E DCR-10/DCR E DCR-100/DCR E17 92 DCR-1000/DCR E18 20 DCR /DCR E19 2 DCR /DCR E20 4 DCR /DCR E21 27 DCR /DCR E22 1 DCR /DCR => dcr /dcr L8 1 DCR /DCR L8 ANSWER 1 OF 1 WPINDEX (C) 2003 THOMSON DERWENT KW [1] CL USE; CL ST USE

204 204 t => l1/dcr(t)prd/kw 179 L1/DCR PRD/KW L3 73 L1/DCR(T)PRD/KW => d dcn drn R00470-K; R00470-P M3 *01* DCN: R00470-K; R00470-P M3 *02* DCN: R00868-K; R00868-S M3 *03* DCN: R00272-K; R00272-S M3 *04* DCN: RA00I9-K; RA00I9-C 0470-P; 0470-U DRN 0272-S; 0272-U; 0470-P; 0470-U; 0868-S; 0868-U

205 205 => fil wpindex => bisphenol a/cn L1 1 BISPHENOL A/CN L1 ANSWER 1 OF 1 WPINDEX MF C15 H16 O2 SMF C15 H16 O2 *1; TOTAL *1; TYPE *1 MW SDCN R00470 SDRN 0470 SMIL CC(C)(c1ccc(O)cc1)c2ccc(O)cc2 ISMI CC(C)(c1ccc(O)cc1)c2ccc(O)cc2

206 206 => sel sdcn l1 SmartSELECT INITIATED New TRANSFER and ANALYZE Commands Now Available See HELP TRANSFER and HELP ANALYZE for Details L4 SEL L1 1- SDCN : 1 TERM => d l4 L4 SEL L1 1- SDCN : 1 TERM TERM # # OCC # DOC % DOC SDCN R00470 ********* END OF L4 ***

207 207 => l4/dcn L5 531 L4/DCN => d kwic L5 ANSWER 1 OF 531 WPINDEX (C) 2002 DCNR00470KR00470P M3 *01* DCN: R00470-K; R00470-P => d 531 an L5 ANSWER 531 OF 531 WPINDEX (C) [06] AN [06]

208 Derwent Compound Number (DCN) Roles DCN roles are searchable appended to individual Derwent Compound Numbers in the DCN field, e.g. => S R00708-P/DCN They cannot be searched on their own, nor linked to an L-numbered answer set with a proximity operator. The following DCN roles are from 1987 available from 1987 onwards, except as indicated.

209 209 Role Definition/Notes A Analysed or detected C Catalyst D Detecting agent R Removing or purifying agent S Intermediate or starting material X Substance removed N New Compound P Known compound produced Q Product defined by its starting material(s) M Component of a Mixture U Use of a single compound E Excipient (from 1998) T Therapeutically active agent or prodrug(from 1998) V Reagent (from 1998) K Known compound (from 1998)

210 210 => sel sdrn l1 SmartSELECT INITIATED New TRANSFER and ANALYZE Commands Now Available See HELP TRANSFER and HELP ANALYZE for Details L6 SEL L1 1- SDRN : 1 TERM => d L6 SEL L1 1- SDRN : 1 TERM TERM # # OCC # DOC % DOC SDRN ********* END OF L6 ***

211 211 => l6/drn 'DRN' IS A RESTRICTED FIELD CODE L7 0 L6/DRN

212 212 => sel l1 cn SmartSELECT INITIATED New TRANSFER and ANALYZE Commands Now Available See HELP TRANSFER and HELP ANALYZE for Details L8 SEL L1 1- CN : 3 TERMS => d 1-3 L8 SEL L1 1- CN : 3 TERMS TERM # # OCC # DOC % DOC CN BISPHENOL-A BISPHENOL A ,4'-DIHYDROXYDIPHENYL- 2,2-PROPANE ********* END OF L8 ***

213 213 => l8/bi L L8/BI => d l an L9 ANSWER OF WPINDEX F [00] AN F [00]

214 214 Searching Structures L1 STRUCTURE UPLOADED => d L1 HAS NO ANSWERS L1 STR

215 215 => l1 full FULL SEARCH INITIATED 06:39:00 FULL SCREEN SEARCH COMPLETED TO ITERATE 100.0% PROCESSED 7089 L SEA SSS FUL L1

216 216 => l2 and (c and h)/els C/ELS H/ELS L L2 AND (C AND H)/ELS MF C14 H16 N2 => l2 and (c and h)/els(s)2/els.cnt PROXIMITY OPERATION NOT ALLOWED

217 217 => l2 and c/els(s)2/els.cnt C/ELS /ELS.CNT C/ELS(S)2/ELS.CNT L L2 AND C/ELS(S)2/ELS.CNT 2 MF C14 H16 N2 => l2 and c/els(s)3/els.cnt C/ELS /ELS.CNT C/ELS(S)3/ELS.CNT L L2 AND C/ELS(S)3/ELS.CNT 3 MF C28 H29 F3 N4 S

218 218 => l4 and l5 L6 424 L4 AND L5 32 MF C36 H41 N3 O2

219 219 => l2 and nc=1 and 2/els.cnt NC= /ELS.CNT L L2 AND NC=1 AND 2/ELS.CNT

220 220 => sel l3 srin SmartSELECT INITIATED New TRANSFER and ANALYZE Commands Now Available See HELP TRANSFER and HELP ANALYZE for Details L4 SEL L3 1- SRIN : 87 TERMS => d 1-10 ans L4 SEL L3 1- SRIN : 87 TERMS TERM # # OCC # DOC % DOC SRIN (ANS: 15,16...

221 221 => d 15 l3 all L3 ANSWER 15 OF 1034 WPINDEX (C) 2002 THOMSON DERWENT AN.S DCR DCSE CN.S Pent-3-enoic acid 4-ethyl-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a- diaza-dibenzo[b,h]fluoren-4-yl ester MF C25 H22 N2 O5 SMF C25 H22 N2 O5 *1; TOTAL *1; TYPE *1 MW SRIN SDCN RA6GK0 CC UNSATURATED FATTY ACIDS

222 222 => l4 SmartSELECT INITIATED New TRANSFER and ANALYZE Commands Now Available See HELP TRANSFER and HELP ANALYZE for Details SEL L4 1 L5 SEL L4 1 : 1 TERM S L5 L6 242 L5 => l4 SmartSELECT INITIATED New TRANSFER and ANALYZE Commands Now Available See HELP TRANSFER and HELP ANALYZE for Details SEL L4 1,3,5 L7 SEL L4 1,3,5 : 3 TERMS S L7 L L7

223 223 => d his L1 STRUCTURE UPLOADED L L1 FULL L L2 AND NC=1 AND 2/ELS.CNT L4 SEL L3 1- SRIN : 87 TERMS L5 SEL L4 1 : 1 TERM L6 242 S L5 L7 SEL L4 1,3,5 : 3 TERMS L S L7 => l6 not l2 L10 37 L6 NOT L2

224 224 => d str L10 ANSWER 1 OF 37 WPINDEX

225 225 => l4/rin 'RIN' IS A RESTRICTED FIELD CODE L12 0 L4/RIN => l2/dcr L L2/DCR => l2 or l8 L L2 OR L8 => l16/dcr L L16/DCR

226 226 Search Question: Find in Wpindex if the reported heterocycle has been used in anxiety treatment. Have been other similar structures used?

227 227 Searching Keywords => fil wpindex => ?heterocycl?(l)treat?(l)(depress? or anxie? or obsess?) L ?HETEROCYCL?(L)TREAT?(L)(DEPRESS? OR ANXIE? OR OBSESS?) => l2 and py=>1999 L L2 AND PY=>1999 dcre => sel dcre L4 SEL L3 1- DCRE : TERMS

228 228 => e /dcre E /DCRE E /DCRE E3 1 --> /DCRE E /DCRE E /DCRE E /DCRE E /DCRE E /DCRE E /DCRE E /DCRE E /DCRE E /DCRE => e /dcr **** START OF FIELD **** E > /DCR E DCR-1/DCR E DCR-10/DCR E DCR-100/DCR E17 92 DCR-1000/DCR E18 20 DCR /DCR E19 2 DCR /DCR E20 4 DCR /DCR E21 27 DCR /DCR E22 1 DCR /DCR

229 229 => l4/dcse L L4/DCSE => Uploading C:\Program Files\stnexp\Queries\dcr1.str

230 230 L6 STRUCTURE UPLOADED => d L6 HAS NO ANSWERS L6 STR

231 231 => l6 full subset=l5 'SUBSET' IS NOT A VALID SEARCH SCOPE => l6 full L7 284 SEA SSS FUL L6 => l7 and l5 L8 24 L7 AND L5

232 232 => d str srin L8 ANSWER 1 OF 24 WPINDEX (C) 2003 THOMSON DERWENT SRIN 00690; 01190

233 233 => sel l8 srin L9 SEL L8 1- SRIN : 3 TERMS => l9/srin L L9/SRIN => l10 not l8 L L10 NOT L8

234 234 => d str L11 ANSWER 1 OF 834 WPINDEX (C) 2003 THOMSON DERWENT

235 235 => d his L ?HETEROCYCL?(L)TREAT?(L)(DEPRESS? OR ANXIE? OR OBSESS?) L L2 AND PY=>1999 L4 SEL L3 1- DCRE : TERMS L L4/DCSE L6 STRUCTURE UPLOADED L7 284 L6 FULL L8 24 L7 AND L5 L9 SEL L8 1- SRIN : 3 TERMS L L9/SRIN L L10 NOT L8 => l11/dcr and treat?(l)(depress? or anxie? or obsess?) L13 23 L11/DCR AND TREAT?(L)(DEPRESS? OR ANXIE? OR OBSESS?) => l13 not l3 L14 7 L13 NOT L3

236 236 => d ti 1-5 L14 ANSWER 1 OF 7 WPINDEX (C) 2003 THOMSON DERWENT TI (+)-1-(3,4-Dichlorophenyl)-3-azabicyclo(3.1.0)hexane, useful for treating depression.

237 237 Sviluppare SRIN


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