2Dopamine regulates working memory and its cellular correlates in the PFC
3Adapted from: Sawaguchi et al. (1986; 1988; 1990a,b)
4How does dopamine regulate working memory at the cellular level in the PFC? Study effects of dopamine on intrinsic properties of PFC neurons.Study effects of dopamine on synaptic inputs to PFC neurons.Make a model incorporating these data and see if you can answer the above question.
18D1 agonists do not enhance response to trains when NMDA receptors are blocked
19GNMDA shift + depression shift Models indicate that the selective increase in depolarization is due to both reduced Pr and enhanced NMDA conductanceSimulated D1DataSimulationD1 conditioncontrolGNMDA shift + depression shiftGNMDA shift aloneData
34How does dopamine regulate working memory at the cellular level in the PFC? It gates the flow of synaptic input into the PFC and regulates network activity via its effects on inhibition.It aids in establishing and stabilizing up-states (delay-period activity) via its actions on INAP, IKS, INMDA, & glutamate release.