Presentation on theme: "Infrastructures use, requirements & prospect in ICT for health domain"— Presentation transcript:
1 Infrastructures use, requirements & prospect in ICT for health domain Karin JohanssonICT for HealthDG Information Society & MediaEuropean Commission
2 ICT for Health research activities Relevant Grid-related activities OutlineICT for Health research activitiesRelevant Grid-related activitiesWhere are we going in the short/medium term?Where do we go beyond FP7?
3 WHO ARE WE? ICT for Health (eHealth) Unit, European Commission Information Society and Media DG established in 1989supported to date > 450 projects worth > € 1 Billioncurrently funds eHealth projects (€ 100 Million/year)The vision (since 1994): “eHealth-enabled citizen-centred care” or equivalently “eHealth-enabled continuity of care”Today’s focusR&D:Personal Health SystemsPatient SafetyModelling and Simulation of Human Physiology and Disease (Virtual Physiological Human)Support to deployment: eHealth Action plan, Large Scale Pilots, Lead market initiative, Recommendation on Interoperability of EHRs, Communication on Telemedicine (2009)Wider than just research support: also includes implementation and deployment support through the CIP and policy activities to take research results further.1994: start of FP5Policy areas:Luba: Action Plan, Cross-Border InteroperabilityChristoph: Communication on TelemedicineMike: Lead Market InitiativeFlora: Large-scale pilots (CIP)PHS: Wearable, implantable, portable systemsPS: IT systems for detecting trends in adverse events (treatments, drugs etc)VPH: Modelling and Simulation of Human Physiology and Disease
4 Budget for research supported by the ICT for Health unit in FP7 Overall € 340 M over 4 years ( )Personalisation of HealthcarePersonal Health Systems (PHS)€ 72 M in € 63 M in 2009Patient safety (PS) - avoiding medical errors€ 30 M in € 30 M in 2009Predictive Medicine – Virtual Physiological Human (VPH)Modelling/simulation of human physiology and disease€ 72 M in € 5 M in € 63 M in 2010Next work programme will cover and will be published on CORDIS in Oct-Nov 2010.
5 ICT for Health research activities Relevant Grid-related activities OutlineICT for Health research activitiesRelevant Grid-related activitiesWhere are we going in the short/medium term?Where do we go beyond FP7?
6 Where are Grid activities most relevant? VPHNeed for data capacity originates from biomedical informatics rootsHuge demand onData storage/managementComputing powerPatient Safety (PS)Early detection of public health eventsRe-use of EHR data for research purposes
7 The Virtual Physiological Human (VPH) concept Based on the ideas of the International Physiome projectThe Virtual Physiological Human is a methodological and technological framework that once established will enable the investigation of the human body as a single complex system.One of the 12 pioneer projects in FP6, The VPH research roadmap developed by project STEP in 2007:The concepts have been elaborated through the physiome initiative and the field of biomedical informaticsIt is mainly the computational framework (infrastructure and tools) which could allow the modelling and simulation of the human physiology. The ultimate goal is to enable the move towards the personalised and predictive medicine. This is a quite ambitious goal which is certainly quite long-term. We are favouring a step wise approach towards this objectives. FP7 Calls 2, 4 and 6 are just first steps in this process.STEP roadmap: For different VPH areas:status and state-of-the-artidentification of gaps in knowledgechallenges to be addressedneeds for research funding- Personalised (patient-specific) healthcare solutions- Early diagnostics & predictive medicine- Understanding diseases for the first timeacross several biological levels
8 Virtual Physiological Human: a schematic picture Computational resourcesApplicationKnowledgeof biological and physiologicalpathways, processes etcData managementModellingConstruction and/or refinement of models on different temporal and spatial scalesIntegration of modelsMultiscale model verificationClinical validationHealth care professionalsHospitalData accessData processingPatientSpecific Data-omicsimagingclinicalpharmaPatientData management is continuously an issue in the modelling and simulation process.We fund in the middle boxes, not so much in data acquisition.Verification of models must be done using independent data sets.Prediction,Early Diagnosis,Treatment
9 First VPH Call: FP7 call 2Technical focus:Patient-specific computational modelling and simulation of organs targeting specific clinical needs.Data integration and new knowledge extraction.Clinical focus:Simulation environments for surgery training, planning and intervention.Prediction of disease or early diagnosis.Simulation and assessment of the efficacy and safety of specific drugs.
10 Results of the 1st VPH call: 15 FP7 projects Results of the 1st VPH call: 15 FP7 projectsIndustryParallel VPH projectsGrid access CACV/ Atheroschlerosis IPLiver surgery STREPBreast cancer/ diagnosis STREPHeart/ LVD surgery STREPOsteoporosisIPOral cancer/ BM D&T STREPCancer STREPNetworking NoEHeart /CV disease STREPThe Virtual Physiological Human is at the heart of the VPH projects.Overview of all the projects funded under Call 2, with a brief explanation of their main field of activity.Vascular/ AVF & haemodialysis STREPLiver cancer/RFA therapy STREPAlzheimer's/ BM & diagnosis STREPHeart /CV disease STREPReproduction from VPH NoESecurity and Privacy in VPH CAClinics
11 Results of the 1st VPH call: 15 FP7 projects Results of the 1st VPH call: 15 FP7 projectsIndustryParallel VPH projectsGrid access CACV/ Atheroschlerosis IPLiver surgery STREPBreast cancer/ diagnosis STREPHeart/ LVD surgery STREPOsteoporosisIPOral cancer/ BM D&T STREPCancer STREPNetworking NoEHeart /CV disease STREPSome areas are better developed than others:Red – cardiovascular projectseuHeartARCHpreDICTARTreatVPH2Green – cancer projectsContraCancrumImppactNeoMarkVascular/ AVF & haemodialysis STREPLiver cancer/RFA therapy STREPAlzheimer's/ BM & diagnosis STREPHeart /CV disease STREPReproduction from VPH NoESecurity and Privacy in VPH CAClinics
12 Second VPH call: FP7 call 4 International Cooperation on VPH Focus:Interoperability (interfaces databases, web services, mark-up languages, meta-data, ontologies)Tools and services for global cooperation (for modelling/simulation, curated models, interconnected libraries)International validation environment (joint verification of clinical relevance of models)Budget: 5M€Results: 5 proposals selected, all of which include international partners.Focused on increasing international cooperation between existing VPH-related projects and similar international projects or initiatives.Retained proposals are currently under negotiation and will hopefully start early 2010.
13 ICT for Patient safety Results: 9 retained (2 IPs, 6 STREPs, 1 SA) Focus of Call:ICT for safer surgeryICT for integration of clinical research and clinical careICT-enabled early detection of public health eventsBudget: 30M€Results: 9 retained (2 IPs, 6 STREPs, 1 SA)But: Public health policy is mainly the responsibility of Directorate General Health and Consumer (DG SANCO) projectsRetained proposals are currently under negotiation and will hopefully start early 2010.13
14 eInfrastructure: the European HPC Service PRACENationalDEISA and EGINational/RegionalWe are an application domain so we are not funding infrastructure, just the applications and interfaces on top of existing infrastructures. But we are closely cooperating with the research infrastructure funded under the Capacity programme. That the reason I would like to give this overview on Infrastructure.Best path: a bottom-up approach.Start with the local resource; if not sufficient, cluster with local network (such a universities etc).If not sufficient, seek to cluster on a national or regional level with supercomputers (DEISA) or EGIIf still not sufficient, and if you are looking for best in the world machine, go for PRACE.EGI: European Grid InitiativeEGEE: Enabling Grids for E-sciencELocalDEISA/PRACE Symposium – Amsterdam, NL••• 1414
15 DEISA: ‘virtual’ HPC services 12 sites in 7 countries connected at 10 Gb/sOver 22,000 CPUs with an aggregated peak performance of close to 1 Peta flopsRunning larger parallel applications in individual sitesEnabling workflow applications with grid technologies (UNICORE)Providing a global data management serviceExtreme Computing InitiativeDEISA is an aggregation of National resources.DEISA resources are accessible through 2 mechanisms:Bid for research through national schemeBid at EU level through Call on DEISA Extreme Computing initiative – this is new!!There are 12 DEISA machines in EuropeDEISA is for highly coupled applications. Where parallelism is possible then EGI might be more relevant.DEISA/PRACE Symposium – Amsterdam, NL••• 1515
16 establishing new organisational model for sustainable grid service provisioning EGI_DS (Design study)NGI-Nordic StatesCoordinatingentity (EGI)NGI-UKNGI-IRLKey elements of new scheme:Coordination/pooling of National and European funding for sustainable service provision and for more efficient planning of investmentsService provisioning beyond project cyclesOne-stop-shop service provisioning (including training) to users who want to access grid-based resourcesNGI-NLNGI-BNGI-PONGI-DNGI-FNGI-CZNGI-SKNGI-AEGI: European Grid InitiativeEGEE: Enabling Grids for E-sciencEEGI is an aggregation of resources. It could be seen as the next step to EGEE but with a quite different approach.EGI will have the following features:Resource provisioning (this is where the focus of EGI lies)EGI will also be middleware neutral (compatible with Glite, UNICORE…). It will also involve the user community to influence the services offeredCompared to EGEE it is much more structured with nodes at national level called National Grid Initiative. These nodes are in the process of creation. In this domain of eInfrastructures, a Call is currently open with a deadline of November 24th 2009.FP7-INFRASTRUCTURESContact information for people working on this call will be shown at the end of the presentation.NGI-ENGI-INGI-PNGI-GR
17 PRACE: preparatory phase Late 2009: 1PF in the top 5Late 2010: 2 PF in the top 5; 1PF in the top 102011: 3 PF in the top 5; 2 PF in the top 102020: an exaflop in the top 5PRACE aims at building EU super computer top of the range.It could link national super computers but also aim at developing new computers. It aims to release 1 or 2 machines per year.Here you see the aims in terms of performance which the they are aiming for.DEISA/PRACE Symposium – Amsterdam, NL••• 1717
18 ICT for Health research activities Relevant Grid-related activities OutlineICT for Health research activitiesRelevant Grid-related activitiesWhere are we going in the short/medium term?Where do we go beyond FP7?
19 Virtual Physiological Human future activities Keep the overall VPH goals:Early diagnostics & Predictive medicinePersonalised (Patient-specific) healthcare solutionBy means of:Modelling & simulation of human physiology and disease-related processesAdd emphasis on tools/infrastructure for biomedical researchersVPH in 2010Call 6 expected to open November 2009 and to close in April 2010Budget 63M€
20 VPH infrastructure needs Demand for:Data managementComputing powerRequirements (coupling research activities with applications)No longer sufficient to make technological advances within the GRID researchEngage usersUsability/user accessibilityRoutinely used in applied research in other domains (VPH and others)Develop culture of sharingNo infrastructure developments can be done in isolation from the application side. This means that a coupling of infrastructure with research activities is essential.Users to us are BMI and/or VPH researchers! This means that it must be easy to access and use grid resources without needing to be an expert on how grid technologies work.Only by showing that the funds which have already been invested in infrastructure are being of benefit to the research community and sociely as a whole can we justify further funding in this field.Sharing of information with other researchers is essential – will come back to this point.
21 VPH Call 6Focus a):Patient-specific computer based models and simulationMultiscale models & simulation of organs/systems targeting specific clinical needs.Better understanding of the functioning of the organs and their pathologies aiming at prediction/early diagnosis.Emphasis on:Integration of existing modelsClinical benefits demonstratedData acquisition, medical, clinical, bio research (if needed) < 25%Access to external computing facilities supportedMore or less same as Call 4, but:Requirement of multiscale models (i.e. integration of anatomical and physiological data from multiple levels: molecular, cell, tissue, organs or systems)Explicit support to HPC access
22 VPH call 6Focus b):ICT tools, services and infrastructures for bio-medical researchers to support at least 2 of the 3 activities:Share data and knowledgeJointly develop and share models/simulatorsCreate collaborative environmentsInterface to access to resources like Grid/HPC infrastructuresAbility to interface with existing medical research infrastructureComplement/compatible with existing methods/standards to be suggested by VPH-NoETheme of this focus: to develop a culture of sharingFocus on tools, services for BMI researcherssharing of data & resultsjoint developments of modelscollaborative enviroments
23 VPH Call 6Focus c) & d)Evaluation and assessment of VPH Projects w.r.t. optimal use and contribution ofShared tools/infrastructureClinical achievementsMarket potential/ penetrationObservatory on achievements and evolution of the broader BMI field (e.g. bioinformatics, Medical informatics, neuro-informatics):Facilitate communication between projectsDissemination and trainingAim at:Sustaining cross collaboration among different fieldsBuild on related NoEs.Important that all stakeholders interested in contributing to these either apply to participate in one of these consortia or provide their point of view to the selected consortia at the appropriate time.
24 ICT for Health research activities Relevant Grid-related activities OutlineICT for Health research activitiesRelevant Grid-related activitiesWhere are we going in the short/medium term?Where do we go beyond FP7?
25 Support projects cutting across research, innovation and deployment As part of COM(2009)116 on « A strategy for ICT R&D Innovation in Europe », the Commission proposedLimited set of project cases that cut across the innovation chainEach project focused on specific characteristics of a pan-European service infrastructures addressing a specific societal goalTo speed up the achievement of results there is a need to orchestrate efforts across research, innovation and deploymente.g. multi-financed large-scale initiatives in FP and CIP and national and regional actions including procurement of R&D and innovationVision for large-scale action which combines all aspects of innovation funding:policyresearchimplementationdeployment
26 Example projects cutting across research, innovation and deployment European Large Scale Action in ICT for HealthICT service infrastructure for personal healthcareSpecific societal goal: better integrated care and management of chronic diseases at the point of need; continuous and personalised care …Specific characteristics: accuracy of measurements, remote control by health professionals, self-monitoring …eHealth has been identified as 1 of 4 potential topics for such a large-scale action.On September 29th there was a consultation meeting held in Brussels to clarify the direction such an eHealth project could take. The report is currently being finalised, and further discussions on the topic will be held on a meeting organised by the Swedish presidency on November 10th-11th in Visby, Sweden.
27 Contact persons DG Information Society and Media Unit “ICT for Health” Virtual Physiological Human team:Joël BacquetKarin JohanssonAmalia VladeInfrastructure team:Enric MitjanaMaria RamalhoBernhard Fabianek Contact person for EGI-related part of FP7-INFRASTRUCTURES :Monika Kacik