3 Visual Pathway Each eye sees both left and right visual field. Ipsilateral information crosses over at optic chiasm.Some connections to superior colliculi.Reflexive eye movmentsOthers go to thalamus (lateral geniculate nuclei) and then cortex.
5 V1Primary visual cortex (V1) lies in calcarine fissure.Complete damage leads to Homonymous hemianopia.Partial damage leads to scotomas
6 V1 – retinotopic mapping V1 is retinotopic: distorted spatial map of visual sceneFovea has massively over represented.
7 V1 damage and blindsight People with damage to V1 fail to report objects presented in their field defect.However, when forced to guess, they can accurately point to location of unseen visual stimulus!Can also accurately report direction of motion.Weiskrantz et al., 1974
8 Implications of Blindsight V1 is crucial for conscious awareness.What explains blindsight? Why do only 20% of V1 patients show blindsight?Incomplete damage to V1? Islands of spared tissue (Gazzaniga, 1994).Typically seen in people who had injury while young – neural plasticity?Small number of indirect connections to later cortical visual centers?Visual connections to colliculi?
9 The visual processing stream Three major streams of vision:SubcorticalDorsalVentralDifferent streams do different things…
10 Cortical visual processing Dorsal system is fast, but color blind.Helps with motor control (Where/How).ParietalMTV5MagnoLGNV1V2V3M-ganglion cellsParvoLGNP-ganglion cellsV1V2ITcortexV4Ventral system is slow, but detailed.Helps with object identification (What).
11 Achromatopsia :: V4Achromatopsia is usually caused by bilateral damage to V4 - lingual and fusiform gyri (occipitotemporal junction) and is characterized by an inability to identify or discriminate colourStill able to perceive form and motion
12 Akinetopsia (Motion Blindness) Zilles reported first case of akinetopsia. Pure cases are rare, as requires bilateral injury.Case LM - akinetopsia43 yr old. Sinus vein thrombosisV5 damaged bilaterally - V1 sparedCould not see movement of objects but could see still objects. People would suddenly appearDiagnosed as agoraphobicCan see movements/reach for/catch very slow moving objects (< 10°/s)
13 V5 timecourseBeckers & Zeki (1995) examined brief V5 disruption using TMS.Motion perception disrupted most with V5 stimulation up to 30ms after visual stimulation onsetV1 stimulation also partially disrupts motion perception, but later (60-70ms after VS onset).Takes 30-50ms for signals to go from V1 to V5Direct route to V5?Reafference to V1?May explain motion performance in blindsight?
14 Three reasons why people might fail to recognize objects: AgnosiasThree reasons why people might fail to recognize objects:Perceptual Deficit: e.g. acuity, field cut, loss of color visionApperceptive agnosia: unable to perceive full shape of object despite intact low level processing.Associative agnosia: ability to perceive shape, but unable to recognize it.
15 Intact low-level perception Apperceptive agnosiaIntact low-level perceptionacuitybrightness discriminationcolor visionUnable to recognize objectsUnable to extract global structure.
16 Associative agnosiaAble to see whole form of shapesNo problem copying figuresHowever, unable to recognize the objects
17 Theoretical explanations: Associative agnosiaTheoretical explanations:Disconnection between visual representation and language?Damage to visual memory representation?Slightly impaired perception?
19 ProsopagnosiaWigan (1844), Quaglino & Borelli (1867), Hughlings Jackson (1872), Charcot & Bernard (1883), Wilbrand (1892)Inability to visually recognize facesEven a spouse’s face does not seem familiar
20 Prosopagnosia - specificity Seems specific to faces. Patients can still recognize others by:SilhouetteVoiceClothingNote: not like amnesia
21 Is face processing special? ProsopagnosiaIs face processing special?Or, are faces simply the most difficult objects we discriminate?Most people withprosopagnosia have difficulty recognizing differences within categories:types of carporcelain fixturesbreed of dogAlso, often suffer achromatopsia
22 Faces are difficult Most objects are identified by unique components However, faces have the same basic components:nose, eyes,ears, hair
23 Are faces special? Farah tried to find objects as difficult as faces: Spectacle framesUndergrads recognized 87% of faces, 67% of eyeglass frames (faces easier)LH recognized only 64% of faces, and 63% of eyeglass frames
27 Assal, Faure & Anderes (1984) report zooagnosic farmer MX Double dissociationsAssal, Faure & Anderes (1984) report zooagnosic farmer MXLost ability to recognise cowsStill recognises facesBruyer et al (1983) report reverseFails to recognise facesIntact perception of cows
28 Double DissociationIf faces are simply difficult, we should not find patients with spared face recognition who are impaired on other tasks.MXRBAccuracyRBMXFacesCows
29 Prosopagnosia Selective to faces in a few patients Unable to recognize facesAble to discriminate equally difficult objects:cowsoffice furniturespectacle framesWhy are ‘pure’ prosopagnosics so rare?Lesions tend to be large?Overlap in processing in most patients?Functional imaging can resolve this question
30 Anatomical considerations Fusiform gyrus.Usually bilateral, occasionally right hemisphere only (Landis et al. 1986)Near V4 (color vision)Functional imaging gives convergent evidence (Sergent & Signoret 1992)
31 Vision in split brain patients Commissurotomy is neurosurgical treatment for intractable epilepsy where the Corpus callosum is completely divided.Allows systematic investigation of hemispheric specialization and integration
32 Split brain patientsBy using rapid (tachistoscopic) stimuli we can avoid eye movements.Using chimeric faces, Sperry projected different images to each hemisphere.Most able to return to work within 2 years of surgery.Typically, appear healthyLanguage‘man’Left handwoman
33 Split brain patients Picture presented in RVF (i.e. to LH) Patient could name or reach for the object correctly with right hand.Picture presented in LVF (i.e. to RH)Patients could not name/describe the objectSubjects could reach for the correctobject with their left handLikewise, unable to find a object felt with one hand by using the other hand.
34 Split brain patients Left hemisphere clearly specialized in language. Right hemisphere appears better at copying designs, reading facial expressions, fitting forms in moldsSimilar effects can be seen in healthy people, e.g. most think A and C look more similar than A and B
35 Cortical visual processing Dorsal system is fast, but color blind.Helps with motor control (Where/How).ParietalMTV5MagnoLGNV1V2V3M-ganglion cellsParvoLGNP-ganglion cellsV1V2ITcortexV4Ventral system is slow, but detailed.Helps with object identification (What).
36 Visual Form Agnosia DF has ventral damage Profound agnosia :: can not even tell orientation of objectMotor control accurate :: motor system functions accurately.Posting taskPatient DFControlsPerceptualmatchingPosting
37 Ventral vs Dorsal damage (Goodale et al.  Curr Biol. 4:604-610) When shown two shapes (left), DF was poor at saying if the shapes were same or different, RV was good at this task.100%chance0%DFRVWhen asked to grasp an object, DF grasped near the centre (like healthy people), RV was poor at this task.DFRVControl25%Frequency0%Distance from centre (mm)
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