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 Copyright 2011 Digital Enterprise Research Institute. All rights reserved. Digital Enterprise Research Institute www.deri.ie Enabling Networked Knowledge.

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Presentation on theme: " Copyright 2011 Digital Enterprise Research Institute. All rights reserved. Digital Enterprise Research Institute www.deri.ie Enabling Networked Knowledge."— Presentation transcript:

1  Copyright 2011 Digital Enterprise Research Institute. All rights reserved. Digital Enterprise Research Institute Enabling Networked Knowledge An Ontology for Clinical Trial Data Integration Dr. Ratnesh Sahay SMC 2013, Manchester, UK

2 Digital Enterprise Research Institute Enabling Networked Knowledge 2 A4 A1 A4 A1 A2 A1 A2 A1 B3 A4 A2 A1 B3 A1 B3 A1 A2 A1 A4 A2 A1 A4 A2 A1 A2 A1 B3 A1 A2 A1 B3 A1 A4 A1 A2 A1 A4 A1 B3 A2 A4 A1 A2 A1 A2 A1 B3 A4 A1 A4 B3 A1 B3 A4 B3 A1 A4 A1 A4 A2 A1 A4 A1 A2 A1 A4 A1 A4 B3 A1 A4 A2 A4 A1 A2 B3 A1 A2 A1 B3 A1 A4 B3 A2 A1 A4 A1 A4 A1 B3 A1 A2 A1 A4 A2 A1 A2 A1 A2 A1 B3 A4 A1 A4 A2 A1 A4 The Problem If you have heterogeneous clinical terminologies and you want to integrate them…. and if scale of integration grows… A ? A1B3 B8A4F E B8 A1 A4 A1 A2 A4 B3 A1 A4 A6 A2 A5 A4 A1 A4 A1 B3 A1 B3 A1 A4 A1 A4 A1 A2 A1 B3 A1 A4 A1 A2 B3 A2 Heterogeneous Clinical Terminologies Terminology Integration Lot of complex terminologies 2/7

3 Digital Enterprise Research Institute Enabling Networked Knowledge Integrating Clinical Terminologies return number of subjects (i.e., patients) that have been administered the drug Insulin and exhibit BMI > 25 and Dyslipidemia and Agoraphobia as adverse events RxNormLOINCSNOMED DSM-4 Legal and Ethical Regulations HL7/openEHR 3/7

4 Digital Enterprise Research Institute Enabling Networked Knowledge Semantic EHR Ontology  The Semantic EHR Ontology represents the clinical trail domain and described as a domain level ontology  Objectives  Enable sharing and linking of healthcare and clinical terminologies  Sharing consistent and unambiguous knowledge for decision making in medical and clinical research domains  (Sub)Domains,  Partially covers Breast Cancer, Diabetic, Adverse Event (AE), Concomitant Medication (CE), Neurology, Genetics, Psychiatric Disorder, and Respiratory  Local institute (domain)-specific variables 4/7

5 Digital Enterprise Research Institute Enabling Networked Knowledge Layering: Semantic EHR Ontology ACGT BFO imports Domain SEHR CHUV Cardiovascular Psychiatric Adverse Events CING Breast Cancer Diabetic Neurology Genetics Adverse Event (AE) ZEINCRO Adverse Event (AE) Concomitant Medication (CE) Respiratory UPPER UMLS, OBO Foundry (Basic Formal Ontology) Advancing Clinico-Genomic Trials on Cancer (ACGT) 5/7 Class1859 Object Property225 Data Property575

6 Digital Enterprise Research Institute Enabling Networked Knowledge Evaluating Semantic EHR Ontology  The questionnaires were answered by clinical experts from various sub- domain of Healthcare and Life Sciences  Clinical experts suggested conceptualisation fixes (i.e., hierarchy and/or names of classes and properties) that suit their local requirements  Clinical experts agree that SEHR ontology covers the needs of the clinical trial domain  We are doing a final (fourth) round of evaluation 6/7

7 Digital Enterprise Research Institute Enabling Networked Knowledge Thank you 7/7


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