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Presentation of the laboratory of Cellular Metabolism

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Presentation on theme: "Presentation of the laboratory of Cellular Metabolism"— Presentation transcript:

1 Presentation of the laboratory of Cellular Metabolism
Péter Bay, PhD University of Debrecen Faculty of Medicine

2 Presentation of the team
3 postdocs, 5 PhD students, 1 technician Peter Bay, PhD Omar Abdul Rahman, PhD Edit Mikó, PhD András Vida, PhD Ádám Dér, MD Tamás Fodor Tünde Kovács Judit Márton Lilla Nagy László Gelenczey-Finta

3 Studies on poly(ADP-ribose) polymerases
Main projects Studies on poly(ADP-ribose) polymerases n NAD+ (ADPR)n + NA PAR PARP-1/2

4 Main projects I. Metabolic role of poly(ADP-ribose) polymerases – mitochondrial regulation Trends Endocrin Metab in press Mol Aspects Med (6): Cell Metab (3):290-5. Cell Metab (4):461-8. Cell Metab (4):

5 II. Metabolic role of poly(ADP-ribose) polymerases – other organs
Main projects II. Metabolic role of poly(ADP-ribose) polymerases – other organs RXR PPARg PARP2 aP2 LPL CD36 stb. PARP2+/+ PARP2-/- ChIP Biochim Biophys Acta Apr;1842(4): J Biol Chem Dec 28;282(52):

6 III. Studies on the Warburg-type metabolism pentose-phosphate shunt
Main projects III. Studies on the Warburg-type metabolism antimetabolies methotrexate (MTX) glucose ATP pentose-phosphate shunt ribose, NADPH glycolysis nucleotides lactate citrate Ac-CoA TCA cycle fatty acids glutamine O2 terminal oxidation ATP Energy sensors AMPK

7 Collaborations UD, Department of Biochemistry and Molecular Biology
DU, Department of Cardiology UD, Department of Dermatology Attila Tóth Ibolya Rutkai Ágnes Czikora Borbála Kiss Fésüs László Nagy László Balajthy Zoltán Ralph Rühl Endre Kristóf Nestlé Institute of Health Sciences, Lausanne Université de Strasbourg, IREBS, FRE3211-CNRS Carles Cantó Josiane Menissier-de Murcia Gilbert de Murcia Valérie Schreiber Francoise Dantzer Jean-Cristophe Ame Aline Huber Adeline Martz Marie-Pierre Reck UD, Department of Medicine CEPE, CNRS UPR9010, Strasbourg György Paragh Zoltán Balogh Ildikó Seres Péter Fülöp Hughues Oudart IMIM, Barcelona, Department of Immunology, PTE, Department of Pediatrics José Yelamos Tamás Décsi Tamás Marosvölgyi EPFL, Lausanne UNIL, Lausanne Inotek Pharmaceuticals Corporation Lucas Liaudet Johan Auwerx Sander Houten Hiroyasu Yamamoto Charles Thomas Riekelt Houtkooper Csaba Szabó Pál Pacher Vaslin Anne University of Debrecen Dept. Of Biophysiscs György Vámosi Uniklinik RWTH Aachen Institut für Biochemie und Molekularbiologie IGMBC, ULP, Strasbourg Rudgers University, Jersey, NJ László Tora György Haskó Balázs Csóka Bernhard Lüscher Weill Cornell Medical College, Department of Pharmacology UD, Department of Radiation Therapy Soleil Synchrotron, Párizs György Trencsényi TamásNagy Judit Péli Anthony A. Sauve Yana Chen Paul Dumas

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