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Presentation of the laboratory of Cellular Metabolism Péter Bay, PhD University of Debrecen Faculty of Medicine.

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Presentation on theme: "Presentation of the laboratory of Cellular Metabolism Péter Bay, PhD University of Debrecen Faculty of Medicine."— Presentation transcript:

1 Presentation of the laboratory of Cellular Metabolism Péter Bay, PhD University of Debrecen Faculty of Medicine

2 3 postdocs, 5 PhD students, 1 technician Peter Bay, PhD Omar Abdul Rahman, PhD Edit Mikó, PhD András Vida, PhD Ádám Dér, MD Tamás Fodor Tünde Kovács Judit Márton Lilla Nagy László Gelenczey-Finta Presentation of the team

3 Main projects Studies on poly(ADP-ribose) polymerases PARP-1/2 n NAD + (ADPR) n + NA PAR

4 Main projects I. Metabolic role of poly(ADP-ribose) polymerases – mitochondrial regulation Trends Endocrin Metab. 2015 in press Mol Aspects Med. 2013 34(6):1168-201. Cell Metab. 2012 16(3):290-5. Cell Metab. 2011 13(4):461-8. Cell Metab. 2011 13(4):450-60.

5 Main projects II. Metabolic role of poly(ADP-ribose) polymerases – other organs RXR PPAR  PARP2 aP2 LPL CD36 stb. PARP2 +/+ RXR PPAR  PARP2 aP2 LPL CD36 stb. PARP2 -/- ChIP Biochim Biophys Acta. 2014 Apr;1842(4):594-602. J Biol Chem. 2007 Dec 28;282(52):37738-46.

6 glycolysis TCA cycle glucose ATP pentose- phosphate shunt ribose, NADPH lactate nucleotides terminal oxidation O2O2 ATP glutamine citrateAc-CoA fatty acids Energy sensors AMPK antimetabolies methotrexate (MTX) Main projects III. Studies on the Warburg-type metabolism

7 EPFL, Lausanne DU, Department of Cardiology Attila Tóth Ibolya Rutkai Ágnes Czikora Université de Strasbourg, IREBS, FRE3211-CNRS UD, Department of Biochemistry and Molecular Biology Fésüs László Nagy László Balajthy Zoltán Ralph Rühl Endre Kristóf CEPE, CNRS UPR9010, Strasbourg Hughues Oudart PTE, Department of Pediatrics Tamás Décsi Tamás Marosvölgyi Inotek Pharmaceuticals Corporation Csaba Szabó Pál Pacher Vaslin Anne IMIM, Barcelona, Department of Immunology, José Yelamos Weill Cornell Medical College, Department of Pharmacology Anthony A. Sauve Yana Chen Soleil Synchrotron, Párizs Paul Dumas UD, Department of Medicine György Paragh Zoltán Balogh Ildikó Seres Péter Fülöp IGMBC, ULP, Strasbourg László Tora György Vámosi University of Debrecen Dept. Of Biophysiscs Johan Auwerx Sander Houten Hiroyasu Yamamoto Charles Thomas Riekelt Houtkooper Josiane Menissier-de Murcia Gilbert de Murcia Valérie Schreiber Francoise Dantzer Jean-Cristophe Ame Aline Huber Adeline Martz Marie-Pierre Reck Nestlé Institute of Health Sciences, Lausanne Carles Cantó Uniklinik RWTH Aachen Institut für Biochemie und Molekularbiologie Bernhard Lüscher Rudgers University, Jersey, NJ György Haskó Balázs Csóka Lucas Liaudet UNIL, Lausanne UD, Department of Dermatology Borbála Kiss Collaborations UD, Department of Radiation Therapy György Trencsényi TamásNagy Judit Péli


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