1. Cellular Respiration continued

2. Review Purpose of cellular respiration is to convert ________ into _____ energy. Aerobic conditions: the pathway is glucoseATP glycolysisPyruvate oxidationKrebs CycleETC

3. Review: KEY TERMS Phosphorylation Adding a phosphate group (PO 4 ) to a molecule  Substrate-level phosphorylation occurs in glycolysis  Oxidative phosphorylation occurs in ETC Kinase an enzyme that transfers a phosphate group (PO 4 ) to a molecule

4. Glycolysis Glucose gets phosphorylated by a kinase That means that P group from ATP is used Phosphorylation destabilizes glucose Glucose splits into 2 pyruvate molecules

6. Net products from Glycolysis (per glucose) 2 pyruvate 2 NADH 2 ATP Total energy = -61.3 kJ

8. Pyruvate Oxidation Pyruvate enters mitochondria and is converted to acetyl CoA (by acetyl coenzyme A) Occurs in the mitochondrial matrix Electron carriers store the energy from the reaction (to be used in the ETC)

9. Pyruvate Oxidation

10. The Krebs Cycle (aka TCA cycle, aka Citric Acid cycle) Acetyl CoA is completely degraded to CO 2 and H 2 O Metabolism is dominated by the Kreb’s cycle Occurs in the mitochondrial matrix Note: Major amounts of acetyl CoA are also produced by the oxidation of fatty acids (BETA OXIDATION)

11. Krebs Cycle Per Glucose 2 full turns: 2ATP 8NADH 4FADH 2

13. March Break Homework Make a “Cheat Sheet” for each of glycolysis (and pyruvate oxidation), Krebs cycle and ETC. Include structure of each molecule Enzymes ADP, ATP, NAD, NADH, other products Highlight or use color to show what’s happening.