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The Immune and Lymph System

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Presentation on theme: "The Immune and Lymph System"— Presentation transcript:

1 The Immune and Lymph System
Chris DePietro Luke Sanderell

2 First: The Lymphatic System
Lymphatic cardiovascular system *Associated*

3 How homeostasis is maintained
4 functions: Absorb excess fluid  bloodstream *Cardiovascular System Capillaries absorb fats bloodstream *in small intestines Production, maintenance, distribute lymphocytes Defense against pathogens

4 The System Consists of: Vessels- 1 way system; begins with capillaries
excess tissue fluid capillary involvement Skeletal muscle Organs Red bone marrow Thymus gland Nodes spleen

5 Excess Tissue Fluid Fluid inside capillary: lymph
Contains: H2O, fat, ions, nutrients, gases, proteins Contains antibodies from lymphocytes Fight infection

6 Capillaries Join to form vessels that merge before entering:
Thoratic Duct- lymph to left of subclavin vein -OR- Right Duct- right of subclavin vein

7 Skeletal Muscle Contraction
Similar to heart in cardiovascular Forces pump lymph through vessels Always outward No flowing back in

8 Organs Red bone marrow: Thymus gland More common in children
Spongy and semisolid red tissue Site of stem cell division Various types of blood cells made Ex: Lymphocytes (mature B cells) Thymus gland In thoraic cavity T cells mature here by thymosin hormone

9 Organs Nodes Spleen Small Occur along vessels
swollen=fighting infection Spleen Red pulp Blood vessels and sinuses Removes old blood cells White pulp In red pulp where B/T cells are Can live without. Weaker immunity

10

11 Video Summary

12 Immunity Human body at 98.6° is ideal for pathogens to thrive
Nonspecific and Specific defenses Bodily defenses keep us alive

13 Nonspecific Defenses 4 defenses Barriers to entry Protective proteins
Phagocytes and natural killer cells Inflammatory response

14 Barriers to Entry Nonchemical, mechanical barriers
Skin and mucous membranes- impermeable In respiratory, digestive, urinary tracts

15 Protective Proteins 3 ways:
When enhanced inflamation histamine release Bind to pathogen surface and engulf White blood cells Joint proteins allow swell and burst

16 Phagocytes and Natural Killer Cells
Kill pathogens Neutrophils in connective tissue Eosinophils- parasite defense Macrophages (everywhere) and dendritic (skin) cells Engulf and destroy by enzyme NK cells Lymphocytes Kill virus infected cells and cancer cells

17 Go to 1:17

18 Inflammatory Response
4 signs: Redness Heat Swelling Pain/inflamation *red/warm- histamine makes capillaries grow Increased permeability=swelling Stimulates nerves=pain Fever natural response Takes pathogen out of “comfort zone”

19 Specific Defenses Second in line Work to immunity
Used when nonspecific is inadequate Work to immunity No infection now or later Attack and directed to antigen Pathogen or cancer cell Explains immunity to chicken pox Takes 5-7 days first infection Shorter each time after (immunity)

20 Specific Defenses B and T cells B cells- antibody immunity
T cells- cell-mediated immunity

21 B cells Produce antibodies Produce memory b cells Release cytokines
Response to antigens Produce memory b cells After killing virusmitosisimmunity and memory Release cytokines Proteins to help cells communicate to protect These proteins attract killer cells

22 T cells Cell immunity Recognize antigen Mitosis produces same T cells
Introduced by macrophage/dendrite Kills antigen on contact Mitosis produces same T cells Memory cells to protect from same antigen

23 Innate V Adaptive

24 So… Innate immunity= nonspecific defenses
Adaptive, or acquired immunity=specific defenses

25 Active and Passive Immunity
Artificial Immunization gives antigen Natural Have pathogen Develop disease and immunity Passive Inject antibodies for protection Passing of antibodies Ex: pregnancy, breast feeding

26

27 Immunity: against us? HIV virus Tissue rejection Host is a T cell
Attacks macrophages Reproduces in T cell to kill T cells Tissue rejection Complicated transplants Antibodies and T cells object new tissue Solution: give immuno-suppressive drug

28 Diseases Autoimmune Diseases Allergies Self antigen or foreign?
Chronic inflammation and attacking Ex: Rheumatoid Arthritis Allergies Hypersensitivity Sensitive to substance antigens Antibodies launch attack to antigens=symptoms

29 Works Cited "Active and Passive Immunity." Web. 15 Apr <www.infoplease.com/leb/sci/A html>. "Innate and Acquired Immunity." School of Veterinary Medicine. University of Wisconson. Web. 15 Apr <www.vetmed.wisc.edu/data/coursematerial/suresl/lecture3.ppt>. "Innate or Non-specific Immunity." Redirect to New Biomedical Graduate Page. Web. 15 Apr <http://rathmicro.med.sc.edu/ghaffar/innate.htm>. Mader, Sylvia S. "Chapter 33- Lymph Transport and Immunity." Biology. New York: McGraw-Hill Higher Education, Print. "Organs of the Lymphatic System." Welcome to Hillfield Strathallan College. Web. 15 Apr <http://www.hsc.on.ca/moffatt/bio3a/circulation/lymphsys.html>. "The Immune System." Rapid Learning Center. Web. 15 Apr <http://www.rapidlearningcenter.com/biology/high-school-biology/The-Immune-System.html>.


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