2Prevnar 13™ - Pneumococcal 13-valent conjugate Clinical Application Indications:Immunization of infants and children against Strep pneumoniae caused by included serotypesImmunization of infants and children against otitis media caused by Strep pneumoniae serotypes 4, 6B, 9V, 14, 18C, 19F, and 23FImmunization of adults ≥50 years against pneumococcal pneumonia and invasive disease caused by included Strep pneumoniae serotypes
3Prevnar 13™ - Pneumococcal 13-valent conjugate Clinical Application Place in therapy:Vaccination used to immunize patients as young as 6 weeks against various strains of Strep pneumoniae
4Prevnar 13™ - Pneumococcal 13-valent conjugate Clinical Application Contraindications:HypersensitivityWarnings:Apnea and Acute IllnessPrecautions:Use in pts w/ altered immunocompetenceUse in Elderly (>65yoa)
5Prevnar 13™ - Pneumococcal 13-valent conjugate Clinical Application Pregnancy:BLactation:Excretion in breast milk unknown/use caution
6Prevnar 13™ - Pneumococcal 13-valent conjugate Drug Facts PharmacologyAdministered as a series of 4 injections given at 2, 4, 6, and months of ageFull efficacy w/in 1 month of the final vaccination
7Prevnar 13™ - Pneumococcal 13-valent conjugate Drug Interactions Drug Interactions – Precipitant DrugsBelimumab: May the therapeutic effect of this Vaccine (inactivate)Fingolimod: May the therapeutic effect of this Vaccine (inactivate)
10Cost: Estimated $430 for complete series Prevnar 13™ - Pneumococcal 13-valent conjugate Prescription InformationDosing:Infants and Children 6 weeks-59 months: 0.5 mL/dose X 4 doses:The first dose may be given as young as 6 weeks - 2 months.The 3 remaining doses are usually given at 4, 6, and monthsThe recommended dosing interval is 4-8 weeksThe minimum interval between doses in children <1 year of age is 1 monthThe minimum interval between the third and fourth dose is 2 monthsCost: Estimated $430 for complete series
11Prevnar 13™ - Pneumococcal 13-valent conjugate vaccine Summary Prevnar 13™ is the successor to the previously-marketed Prevnar® and is used in patients as young as 6 weeks.Prevnar 13™ contains an additional 6 serotypes of Streptococcus pneumoniae, compared to the 7 serotypes provided in the original Prevnar® formulation.The CDC has announced that young children appear to be at increased risk of febrile seizures when given the pneumococcal conjugate vaccine (PCV 13) at the same time as the inactivated influenza virus vaccine (TIV). The risk appears to be greatest from ages months. Because febrile seizures are typically benign and occur in 2% to 5% of all young children, the ACIP does not recommend a delay in administration of either vaccine or altering the vaccine schedule in any manner due to the potential risk of infection.