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Psychoneuroimmunology and HIV Phil Kucab Mind-Body Medicine A brief look at the psyche, the neuroendocrine system and the immune system.

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Presentation on theme: "Psychoneuroimmunology and HIV Phil Kucab Mind-Body Medicine A brief look at the psyche, the neuroendocrine system and the immune system."— Presentation transcript:

1 Psychoneuroimmunology and HIV Phil Kucab Mind-Body Medicine A brief look at the psyche, the neuroendocrine system and the immune system

2 Michael Irwin, Kavita Vedhara (2005). Human Psychoneuroimmunology. Oxford University Press. ISBN Thomas C. Neylan, M.D. "Hans Selye and the Field of Stress Research" J Neuropsychiatry Clin Neurosci 10:230, May 1998 Freeman H, Elmadjian F. The relationship between blood sugar and lymphocyte levels in normal and psychotic subjects. Psychosom Med 1947; 9: 226–33. Phillips L, Elmadjian F. A Rorschach tension score and the diurnal lymphocyte curve in psychotic subjects. Psychosom Med 1947; 9: 364–71 Vaughan WTJ, Sullivan JC, Elmadjian F. Immunity and schizophrenia. Psychosom Med 1949; 11: 327–33. Solomon GF, Moos RH. Emotions, immunity, and disease: a speculative theoretical integration. Arch Gen Psychiatry 1964; 11: 657–74 R Ader and N Cohen. Behaviorally conditioned immunosuppression. Psychosomatic Medicine, Vol 37, Issue Robert Ader- Robert Ader - Papers on Psychoneuroimmunology. Pert CB, Ruff MR, Weber RJ, Herkenham M. Neuropeptides and their receptors: a psychosomatic network. 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"Drug disease interactions: role of inflammatory mediators in depression and variability in antidepressant drug response". J Pharm Pharm Sci. 2006;9(3): O'Brien SM, Scott LV, Dinan TG. "Cytokines: abnormalities in major depression and implications for pharmacological treatment". Hum Psychopharmacol Aug;19(6): Roberts, Thomas B. (2006). "Do Entheogen-induced Mystical Experiences Boost the Immune System?: Psychedelics, Peak Experiences, and Wellness." Chapter 6 in Psychedelic Horizons. Westport, CT: Praeger/Greenwood. HIV and stress = 2068

3 The goal is to stay as healthy as possible as long as possible

4 Viral Load CD4+ T-Cell Count H ow do we measure health status in HIV positive people ? 1 = speed of train = track remaining

5 Finding out you are HIV positive is stressful 7

6 more rapid HIV progression ? Is depression associated with be depressed Lyketsos, JAMA, 1993 were more likely to Men with more symptoms 38% greater loss Burack, JAMA, 1993 of CD4+ T-cells/year

7 AIDS P rogression to AIDS and Stressful Stressful Life Events. 8

8 Is there a ? basis biological

9 “Slow HIV progression is CCR5 receptor density. ” correlated with low 10 “ norepinephrine enhanced replication of both CCR5 in vitro via chemokine receptor up-regulation and enhanced viral gene expression” 3

10 by stress, “ To the extent that one’s medical condition and/or symptoms are caused or made worse we can help. ” Herbert Benson, MD Benson-Henry Institute for Mind-Body Medicine

11 M ost frequently used alternative and complementary therapies 5

12 Non-exercise control showed significant increases in anxiety and depression as well as decreases in their NK cell count 5

13 exercise treatment group Those in the exercise treatment group showed no similar changes and showed a significant increase in CD4+ Lymphocyte levels. 5

14 Prayer has been clinically examined in an HIV-negative cohort with regard to self- esteem, anxiety, depression and showed significant improvement in 11 outcome measures. (O’Laire, 1997) The majority HIV+ participants increase their practice of prayer since their HIV diagnosis. 5

15 Massage boosts immune system function by : Reducing anxiety and stress Increasing white blood cell counts Decreasing levels of cortisol Activating natural killer cells

16 Reframing challenges may not change reality, but it can change attitude.


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