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Confidential Pork Quality A look at a new management option Dr. James Bradford DVM, MS, Dipl ABVP Pfizer Animal Health.

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Presentation on theme: "Confidential Pork Quality A look at a new management option Dr. James Bradford DVM, MS, Dipl ABVP Pfizer Animal Health."— Presentation transcript:

1 Confidential Pork Quality A look at a new management option Dr. James Bradford DVM, MS, Dipl ABVP Pfizer Animal Health

2 Confidential Todays purpose Brief you on a new technology currently under FDA review Review the science behind the product Get your thoughts Confidential

3 What is the label claim? … intended for temporary immunological castration (suppresses testicular function) to control boar taint in intact male pigs intended for slaughter. – Veterinary prescription product only – Classified as a production tool – First of its kind in the U.S. Confidential

4 What causes boar taint (off odor)? Its the result of two naturally occurring substances, androstenone and skatole, which begin to accumulate in the fat tissue of intact male pigs as they enter puberty

5 Confidential What options exist for managing off odor? Nutrition Early harvest Genetic selection Physical castration Confidential

6 Managing off odor with nutrition Skatole levels can be decreased by using fermentable carbohydrates in pig diets However, skatole can also be absorbed from manure Only solves half the problem (doesnt address androstenone) Confidential

7 Managing off odor with early harvest Harvesting prior to puberty is effective There are significant disadvantages, including loss of total pig value The UK and Ireland practice early harvest Confidential

8 Managing off odor with genetics Managing off odor by marker-assisted selection may be a future option But its probably years off Confidential

9 Managing off odor with physical castration Used with 95% of the male pig population globally for centuries Highly efficacious Reduces aggressive male pig behavior Confidential

10 What do we give up? All the natural growth advantages of raising an intact male pig: –Better feed efficiencies 1 –Improved growth performance 1 –Greater yield of lean meat 1 Less mortality, morbidity 2 (Photo of barrow) 1.Suster et al. Longitudinal DXA measurements demonstrate lifetime differences in lean and fat tissue deposition in individually penned and group-penned boars and barrows. Australian Journal of Agricultural Research. 2006:57: Allison, J. The impact of physical castration on pig health. Proceedings of Pfizer International Swine Symposium. Ottawa, Canada. 2009: Confidential

11 We could keep all the natural growth advantages by raising intact male pigs … while still ensuring consumers the same high quality pork experience they enjoy today? What if … Confidential

12 For the past 10 years theres been an immunological product that has been doing just that, globally …

13 Confidential Introducing Improvac

14 Confidential Approved in 57 countries, including the EU and Japan < Targeted for 2011

15 Confidential What is Improvac? A protein compound that uses the pigs natural immune system to control the substances that can create off odor in pork Temporary affect Available by veterinary prescription only Vaccine* Confidential * The U.S. form of Improvac will not be classified as a vaccine.

16 Confidential Improvac is NOT Chemical castration Hormone or growth promotant –Studies have demonstrated the Improvac antigen has no intrinsic hormonal activity 1 A genetically modified product 1.Clarke et al. Inherent food safety of a synthetic gonadotropin releasing factor (GnRF) vaccine for swine. International Journal of Applied Research in Veterinary Medicine. 2008:6:7-14.

17 Confidential How does this product work? Show video clip that describes how product works (from Improvac site)

18 Confidential What is the process?

19 Confidential VIDEO CLIP: Canadian video of administration How is it administered?

20 Confidential How does this product perform?

21 Confidential Efficacy As effective as current practices –10 years of studies* show efficacy greater than 99% * Refer to 55+ peer-reviewed studies showing its efficacy, safety and behavior results. Confidential

22 Efficacy Incidence of androstenone and skatole in fat tissue from intact male pigs. Nearly 50% had off odor (boar taint) above the sensory threshold. Not a problem Long-term damage to reputation of pork Risk of consumer complaints

23 Confidential Efficacy Male pigs on the IMPROVAC program (n=228) Confidential

24 Safety Animal: No adverse effects in laboratory studies 1 Worker: 25 million doses safely administered with only a few minor incidents (Vaccination photo) Confidential 1.Singayan-Fajardo et al. Effect of Improvac on the eating quality and acceptability of boar pork. In Proceedings 3rd Asian Pig Vet Society Congress. Wuhan, China

25 Confidential Human and food safety Its safe 1 –No withdrawal time, globally –No oral activity –Product is only active when given by injection More than 10 years of experience in Australia and New Zealand (Photo of people enjoying pork) Confidential 1.Clarke et al. Inherent food safety of a synthetic gonadotropin releasing factor (GnRF) vaccine for swine. International Journal of Applied Research in Veterinary Medicine. 2008:6:7-14.

26 Confidential Meat quality In 17 comparison studies, the pork quality was found to be the same as physical castrates or female pigs – pH – Drip loss/leanness – Shear force/tenderness Boar Improvac Castrate Confidential – Juiciness –Color

27 Confidential Feed conversion & sustainability Compared with barrows there is: –Improvement in feed efficiency 1,2 –Reduction in greenhouse gases, fecal waste 3 1.Moore et al. Paylean® improves feed conversion efficiency of entire and immunocastrated male pigs In J.E. Paterson (Ed.), Manipulating Pig Production X. Proceedings biennial conference of the Australasian Pig Science Association. Christchurch, New Zealand Dikeman, M. Effects of metabolic modifiers on carcass traits and meat quality. Meat Science. 2007: 77: Hennessy, M. Society benefits: The environment. Proceedings of Pfizer International Swine Symposium. Ottawa, Canada. 2009: Confidential

28 Economic impact 8% to 10% increase in feed efficiency 1 Increase in overall yield of lean pork 2 –8 pounds extra lean meat per carcass 1.Crane, J. Improvac®: Product profile, safety and efficacy. Proceedings of Pfizer International Swine Symposium. Ottawa, Canada. 2009: McKeith et al. Impact of using vaccination with Improvac® rather than physical castration on the carcass characteristics of finishing male pigs. Proceedings International Congress Meat Science & Technology. Copenhagen, Denmark Confidential

29 Animal behavior Animals have low aggression, reduced mounting compared to intact male pigs 1 –Some signs of aggression occur at the onset of puberty –22 weeks, 180 lbs. (Photo of sleeping pig/finisher stage) 1.Dunshea, F. Impact of immunization against GnRF on growth performance of male pigs. Proceedings of Pfizer International Swine Symposium. Ottawa, Canada. 2009: Confidential

30 Effect on the animal Decreases pre-weaning mortality 1 Pigs maintain natural growth characteristics 1 Confidential 1.Allison, J. The impact of physical castration on pig health. Proceedings of Pfizer International Swine Symposium. Ottawa, Canada. 2009:22-25.

31 Confidential Cronin et al. (2003) video monitoring study The results of the experiment suggest that the social and feeding behaviors of immuno-castrated males at 21 weeks were similar to surgically- castrated males. Cronin et al. The effects of immuno- and surgical-castration on the behavior and consequently growth of group-housed, male finisher pigs. Applied Animal Behavior Science. 2003:81(2)

32 Confidential Housing of male pigs vaccinated against GnRF in single sex groups of 12 individuals does not increase behavioral problems in the fattening period compared with surgically castrated males. Baumgartner et al. The behavior of male fattening pigs following either surgical castration or vaccination with a GnRF vaccine. Applied Animal Behavior Science. 2010:124(1): Baumgartner et al. (2010) video monitoring study

33 Confidential Fàbrega et al. (2010) video monitoring study Results from this study indicate that some welfare aspects, such as a reduced aggression and mounting behavior, may be improved by vaccination against GnRH… Fàbrega et al. Effect of vaccination against gonadotrophin-releasing hormone, using Improvac®, on growth performance, body composition, behavior and acute phase proteins. Livestock Science. 2010:132(1):53-59.

34 Confidential Rydhmer et al. (2010) After the second injection, immuno- castrated pigs showed less non- violent social and aggressive behaviors than entire male pigs of the same age. Rydhmera et al. Immuno-castration reduces aggressive and sexual behavior in male pigs. Animal. 2010:4:

35 Confidential Zamaratskaia et al. (2008) Immuno-castrated pigs remained sexually inactive throughout the study. Zamaratskaia et al. Long-term effect of vaccination against gonadotropin-releasing hormone, using Improvac, on hormonal profile and behavior of male pigs. Animal Reproduction Science. 2008:108(1):37-48.

36 Confidential We want your thoughts Wed like to get this peer-reviewed research validated by U.S. animal behavior experts

37 Confidential Getting the product right is only half the equation Equally important is to get the process right Success

38 Confidential Whats the quality assurance process? Unprecedented QA process in Brazil … –Verified, certified process –Prescription product –Administered only by trained personnel –Adding traceability system Confidential

39 What is the veterinarians role? Prescribe product Verification process Certification process After training is complete, vets invited to be part of application process Confidential AK: Slide 40 on vet's role --- is this for the US?? No clear to me and we need to be careful on this one as it varies by region. At a minimum, spell out "vet"...

40 Confidential We could have all the natural growth advantages by raising intact male pigs Is this a viable option? … while still ensuring consumers the same high quality pork experience they enjoy today? Confidential What if…

41 Confidential Thank you!


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