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Effect of Diabetes Mellitus on Sepsis Induced Multiple Organ Dysfunction Syndrome By Hayes Brown.

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Presentation on theme: "Effect of Diabetes Mellitus on Sepsis Induced Multiple Organ Dysfunction Syndrome By Hayes Brown."— Presentation transcript:

1 Effect of Diabetes Mellitus on Sepsis Induced Multiple Organ Dysfunction Syndrome By Hayes Brown

2 Need Each year 500,000 people develop sepsis, with a survival rate of 29 percent Each year 500,000 people develop sepsis, with a survival rate of 29 percent Millions are spent on patient safety research Millions are spent on patient safety research 250,000 die each year in the United states 250,000 die each year in the United states

3 Knowledge Base

4 Cytokine

5 Diabetes Mellitus Death in women from diabetes

6 Type 1 and Type 2

7 DM and Sepsis

8 Knowledge Base Studies could help determine the relationship of DM and reduced risk of ALI Studies could help determine the relationship of DM and reduced risk of ALI

9 Suggested Reasons Hospitalized Earlier Hospitalized Earlier Red blood cell deformability increases risk of renal failure Red blood cell deformability increases risk of renal failure Diabetics more vulnerable to bacteremia Diabetics more vulnerable to bacteremia

10 Literature Review Dr Tomsen (2008)-heightened risk of infections in diabetic people Dr Tomsen (2008)-heightened risk of infections in diabetic people Dr. Reimar(2007)-patients with bacteremia caused by E. coli and related bacteria found about 17 percent had diabetes, compared with 6% without diabetes Dr. Reimar(2007)-patients with bacteremia caused by E. coli and related bacteria found about 17 percent had diabetes, compared with 6% without diabetes Dr. Friedman(2005)- DM Dr. Friedman(2005)- DM patients have a greater risk of renal failure due risk of renal failure due to red blood cell deformibility

11 Literature Review Dr. Annette Esper (2006)-patients with Diabetes Mellitus less likely to develop respiratory failure during periods of sepsis, but more likely to develop infection of the urinary system Dr. Annette Esper (2006)-patients with Diabetes Mellitus less likely to develop respiratory failure during periods of sepsis, but more likely to develop infection of the urinary system Dr. Martin- those with (2006) Dr. Martin- those with (2006) DM less likely to develop DM less likely to develop respiratory infection because DM patients may be hospitalized earlier hospitalized earlier

12 Bibliography ^ Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A, Steingrub JS, Garber GE, Helterbrand JD, Ely EW, Fisher CJ Jr ( ). "Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group. Efficacy and safety of recombinant human activated protein C for severe sepsis ^ Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A, Steingrub JS, Garber GE, Helterbrand JD, Ely EW, Fisher CJ Jr ( ). "Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group. Efficacy and safety of recombinant human activated protein C for severe sepsis ^Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group. Efficacy and safety of recombinant human activated protein C for severe sepsis ^Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group. Efficacy and safety of recombinant human activated protein C for severe sepsis Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G (Apr 2003). "2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G (Apr 2003). "2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference Meduri GU, Golden E, Freire AX, et al (Apr 2007). "Methylprednisolone infusion in early severe ARDS: results of a randomized controlled trial Meduri GU, Golden E, Freire AX, et al (Apr 2007). "Methylprednisolone infusion in early severe ARDS: results of a randomized controlled trialMethylprednisolone infusion in early severe ARDS: results of a randomized controlled trialMethylprednisolone infusion in early severe ARDS: results of a randomized controlled trial Cannon JG (2000). "Inflammatory Cytokines in Nonpathological States". News Physiol Sci. 15: Cannon JG (2000). "Inflammatory Cytokines in Nonpathological States". News Physiol Sci. 15: Kabay B, Kocaefe C, Baykal A, et al. (2007). "Interleukin-10 gene transfer: prevention of multiple organ injury in a murine cecal ligation and puncture model of sepsis". World J Surg 31 Kabay B, Kocaefe C, Baykal A, et al. (2007). "Interleukin-10 gene transfer: prevention of multiple organ injury in a murine cecal ligation and puncture model of sepsis". World J Surg 31 Janeway CA, et al., ed (2005). Immunobiology. The immune system in Health and Disease (6th ed.). New York: Taylor & Francis Group; Garland Science Janeway CA, et al., ed (2005). Immunobiology. The immune system in Health and Disease (6th ed.). New York: Taylor & Francis Group; Garland Science Lucas AD, Greaves DR (November 2001). "Atherosclerosis: role of chemokines and macrophages". Expert Rev Mol Med 3 (25): 1–18. Lucas AD, Greaves DR (November 2001). "Atherosclerosis: role of chemokines and macrophages". Expert Rev Mol Med 3 (25): 1–18. Dellinger RP, Levy MM, Carlet JM, et al., for the International Surviving Sepsis Campaign Guidelines Committee. (2008). Dellinger RP, Levy MM, Carlet JM, et al., for the International Surviving Sepsis Campaign Guidelines Committee. (2008). McKenna M (December 2008). "Controversy swirls around early goal-directed therapy in sepsis: pioneer defends ground- breaking approach to deadly disease". Ann Emerg Med 52 (6): 651–4 McKenna M (December 2008). "Controversy swirls around early goal-directed therapy in sepsis: pioneer defends ground- breaking approach to deadly disease". Ann Emerg Med 52 (6): 651–4 Carr R, Brocklehurst P, Doré CJ, Modi N (January 2009). "Granulocyte-macrophage colony stimulating factor administered as prophylaxis for reduction of sepsis in extremely preterm, small for gestational age neonates (the PROGRAMS trial): a single-blind, multicentre, randomised controlled trial" Carr R, Brocklehurst P, Doré CJ, Modi N (January 2009). "Granulocyte-macrophage colony stimulating factor administered as prophylaxis for reduction of sepsis in extremely preterm, small for gestational age neonates (the PROGRAMS trial): a single-blind, multicentre, randomised controlled trial"


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