Presentation is loading. Please wait.

Presentation is loading. Please wait.

J Heart Lung Transplant 2009;28: 989-1049 HEART-LUNG TRANSPLANTATION Overall ISHLT 2009.

Similar presentations


Presentation on theme: "J Heart Lung Transplant 2009;28: 989-1049 HEART-LUNG TRANSPLANTATION Overall ISHLT 2009."— Presentation transcript:

1 J Heart Lung Transplant 2009;28: HEART-LUNG TRANSPLANTATION Overall ISHLT 2009

2 J Heart Lung Transplant 2009;28: NUMBER OF HEART-LUNG TRANSPLANTS REPORTED BY YEAR ISHLT NOTE: This figure includes only the heart-lung transplants that are reported to the ISHLT Transplant Registry. As such, this should not be construed as evidence that the number of heart-lung transplants worldwide has declined in recent years. 2009

3 J Heart Lung Transplant 2009;28: AVERAGE CENTER VOLUME Heart-Lung Transplants: January 1, June 30, 2008 ISHLT 2009

4 J Heart Lung Transplant 2009;28: DISTRIBUTION OF HEART-LUNG TRANSPLANTS BY CENTER VOLUME Heart-Lung Transplants: January 1, June 30, 2008 ISHLT 2009

5 J Heart Lung Transplant 2009;28: DISTRIBUTION OF HEART-LUNG TRANSPLANTS BY LUNG CENTER VOLUME Lung Transplants: January 1, June 30, 2008 ISHLT 2009

6 J Heart Lung Transplant 2009;28: HEART-LUNG TRANSPLANTATION Kaplan-Meier Survival for All Ages (Transplants: January June 2007) ISHLT 2009

7 J Heart Lung Transplant 2009;28: HEART-LUNG TRANSPLANTATION Adult Recipients ISHLT 2009

8 J Heart Lung Transplant 2009;28: DIAGNOSIS IN ADULT HEART-LUNG TRANSPLANTS (January June 2008) Other includes cancer, LAM, OB, sarcoidosis, bronchiectasis ISHLT 2009

9 J Heart Lung Transplant 2009;28: DIAGNOSIS IN ADULT HEART-LUNG TRANSPLANTS (Transplants: January June 2008) Diagnosis N (%) Congenital Heart Disease921 (34.9%) Idiopathic Pulmonary Arterial Hypertension719 (27.2%) Cystic Fibrosis373 (14.1%) COPD/Emphysema101 ( 3.8%) Acquired Heart Disease77 ( 2.9%) Idiopathic Pulmonary Fibrosis76 ( 2.9%) Alpha-153 ( 2.0%) Sarcoidosis37 ( 1.4%) Re-Transplant: Not Obliterative Bronchiolitis31 ( 1.2%) Re-Transplant: Obliterative Bronchiolitis24 ( 0.9%) Bronchiectasis20 ( 0.8%) Obliterative Bronchiolitis (not Re-Transplant)14 ( 0.5%) Other193 ( 7.3%) ISHLT 2009

10 J Heart Lung Transplant 2009;28: DIAGNOSIS IN ADULT HEART-LUNG TRANSPLANTS BY ERA (Transplants: January June 2008) Other includes OB (non-ReTX), Bronchiectasis, Sarcoidosis ISHLT 2009

11 J Heart Lung Transplant 2009;28: ADULT HEART-LUNG TRANSPLANTATION Indications By Year (%) ISHLT 2009

12 J Heart Lung Transplant 2009;28: ADULT HEART-LUNG TRANSPLANTATION Indications By Year (Number) ISHLT 2009

13 J Heart Lung Transplant 2009;28: ADULT HEART-LUNG TRANSPLANTS: AGE DISTRIBUTION BY LOCATION Transplants between January 2000 and June 2008 ISHLT 2009

14 J Heart Lung Transplant 2009;28: ADULT HEART-LUNG TRANSPLANTS: DIAGNOSIS DISTRIBUTION BY LOCATION Transplants between January 2000 and June 2008 ISHLT 2009

15 J Heart Lung Transplant 2009;28: ADULT HEART-LUNG TRANSPLANTS: DONOR AGE DISTRIBUTION BY LOCATION Transplants between January 2000 and June 2008 ISHLT 2009

16 J Heart Lung Transplant 2009;28: HEART-LUNG TRANSPLANTATION Kaplan-Meier Survival for Adult Recipients (Transplants: January June 2007) ISHLT 2009

17 J Heart Lung Transplant 2009;28: HEART-LUNG TRANSPLANTATION Kaplan-Meier Survival for Adult Recipients by Era (Transplants: January June 2007) ISHLT 2009

18 J Heart Lung Transplant 2009;28: ADULT HEART-LUNG TRANSPLANTATION Kaplan-Meier Survival By Diagnosis (Transplants: January 1990 – June 2007) ISHLT 2009

19 J Heart Lung Transplant 2009;28: ADULT HEART-LUNG TRANSPLANTATION Kaplan-Meier Survival By Diagnosis Conditional on Survival to 1 Year (Transplants: January 1990 – June 2007) ISHLT 2009

20 J Heart Lung Transplant 2009;28: ADULT HEART-LUNG RECIPIENTS Functional Status of Surviving Recipients (Follow-ups: April 1994 – June 2008) ISHLT 2009

21 J Heart Lung Transplant 2009;28: ADULT HEART-LUNG RECIPIENTS Functional Status of Surviving Recipients For the Same Patients (Follow-ups: April 1994 – June 2008) ISHLT 2009

22 J Heart Lung Transplant 2009;28: ADULT HEART-LUNG RECIPIENTS Employment Status of Surviving Recipients (Follow-ups: April 1994 – June 2008) ISHLT 2009

23 J Heart Lung Transplant 2009;28: ADULT HEART-LUNG RECIPIENTS: Rehospitalization Post-transplant of Surviving Recipients (Follow-ups: April June 2008) ISHLT 2009

24 J Heart Lung Transplant 2009;28: ADULT HEART-LUNG RECIPIENTS Induction Immunosuppression For transplants between January 2001 through June 2008 ISHLT Analysis is limited to patients who were alive at the time of the follow-up 2009

25 J Heart Lung Transplant 2009;28: ADULT HEART-LUNG RECIPIENTS Induction Immunosuppression (Transplants: January December 2007) ISHLT Analysis is limited to patients who were alive at the time of the follow-up 2009

26 J Heart Lung Transplant 2009;28: ADULT HEART-LUNG RECIPIENTS Induction Immunosuppression (Transplants: January December 2007) ISHLT Any Induction Polyclonal ALG/ATG OKT3 IL2R-antagonist Analysis is limited to patients who were alive at the time of the follow-up 2009

27 J Heart Lung Transplant 2009;28: ADULT HEART-LUNG RECIPIENTS Maintenance Immunosuppression at Time of Follow-up For follow-ups between January 2001 through June 2008 NOTE: Different patients are analyzed in Year 1 and Year 5 ISHLT Analysis is limited to patients who were alive at the time of the follow-up 2009

28 J Heart Lung Transplant 2009;28: ADULT HEART-LUNG RECIPIENTS Maintenance Immunosuppression Drug Combinations at Time of Follow-up For follow-ups between January 2001 through June 2008 NOTE: Different patients are analyzed in Year 1 and Year 5 ISHLT Analysis is limited to patients who were alive at the time of the follow-up 2009

29 J Heart Lung Transplant 2009;28: POST-HEART-LUNG TRANSPLANT MORBIDITY FOR ADULTS Cumulative Prevalence in Survivors within 1 Year Post-Transplant (Follow-ups: April June 2008) ISHLT 2009

30 J Heart Lung Transplant 2009;28: POST-HEART-LUNG TRANSPLANT MORBIDITY FOR ADULTS Cumulative Prevalence in Survivors within 5 Years Post-Transplant (Follow-ups: April June 2008) ISHLT 2009

31 J Heart Lung Transplant 2009;28: Freedom from Coronary Artery Vasculopathy For Adult Heart-Lung Recipients (Follow-ups: April 1994-June 2008) ISHLT 2009

32 J Heart Lung Transplant 2009;28: Freedom from Bronchiolitis Obliterans Syndrome For Adult Heart-Lung Recipients (Follow-ups: April 1994-June 2008) ISHLT 2009

33 J Heart Lung Transplant 2009;28: Freedom from Severe Renal Dysfunction* For Adult Heart-Lung Recipients (Follow-ups: April 1994-June 2008) ISHLT 2009

34 J Heart Lung Transplant 2009;28: MALIGNANCY POST-HEART-LUNG TRANSPLANT FOR ADULTS Cumulative Prevalence in Survivors (Follow-ups: April 1994-June 2008) Malignancy/Type1-Year Survivors 5-Year Survivors 10-Year Survivors No Malignancy 352 (93.1%)119 (88.8%)32 (84.2%) Malignancy (all types combined) 26 (6.9%)15 (11.2%)6 (15.8%) Malignancy Type* Skin246 Lymph1860 Other430 Type Not Reported220 ISHLT * Recipients may have experienced more than one type of malignancy so sum of individual malignancy types may be greater than total number with malignancy. 2009

35 J Heart Lung Transplant 2009;28: Freedom from Malignancy For Adult Heart-Lung Recipients (Follow-ups: April June 2008) ISHLT 2009

36 J Heart Lung Transplant 2009;28: ADULT HEART-LUNG TRANSPLANT RECIPIENTS: Cause of Death (Deaths: January June 2008) CAUSE OF DEATH 0-30 Days (N = 282) 31 Days - 1 Year (N = 217) >1 Year - 3 Years (N = 187) >3 Years - 5 Years (N = 134) >5 Years (N = 274) BRONCHIOLITIS 04 (1.8%)39 (20.9%)26 (19.4%)43 (15.7%) ACUTE REJECTION 3 (1.1%)6 (2.8%)2 (1.1%)1 (0.7%)1 (0.4%) LYMPHOMA 08 (3.7%)10 (5.3%)5 (3.7%)5 (1.8%) MALIGNANCY, OTHER 03 (1.4%)7 (3.7%)4 (3.0%)16 (5.8%) CMV 01 (0.5%)01 (0.7%)0 INFECTION, NON-CMV 51 (18.1%)76 (35.0%)60 (32.1%)43 (32.1%)80 (29.2%) GRAFT FAILURE 82 (29.1%)52 (24.0%)31 (16.6%)25 (18.7%)54 (19.7%) CARDIOVASCULAR 24 (8.5%)9 (4.1%)12 (6.4%)9 (6.7%)18 (6.6%) TECHNICAL 57 (20.2%)6 (2.8%)1 (0.5%)1 (0.7%)0 OTHER 65 (23.0%)52 (24.0%)25 (13.4%)19 (14.2%)57 (20.8%) ISHLT 2009

37 J Heart Lung Transplant 2009;28: ADULT HEART-LUNG TRANSPLANT RECIPIENTS: Relative Incidence of Leading Causes of Death (Deaths: January June 2008) ISHLT 2009

38 J Heart Lung Transplant 2009;28: HEART-LUNG TRANSPLANTATION Pediatric Recipients ISHLT 2009

39 J Heart Lung Transplant 2009;28: AGE DISTRIBUTION OF PEDIATRIC HEART-LUNG RECIPIENTS (Transplants: January June 2008) ISHLT 2009

40 J Heart Lung Transplant 2009;28: AGE DISTRIBUTION FOR DONORS OF PEDIATRIC HEART- LUNG RECIPIENTS (Transplants: January June 2008) ISHLT 2009

41 J Heart Lung Transplant 2009;28: AGE DISTRIBUTION OF PEDIATRIC HEART-LUNG RECIPIENTS By Year of Transplant Number of Transplants ISHLT NOTE: This figure includes only the heart transplants that are reported to the ISHLT Transplant Registry. As such, this should not be construed as evidence that the number of pediatric heart- lung transplants worldwide has declined in recent years. 2009

42 J Heart Lung Transplant 2009;28: AGE DISTRIBUTION OF PEDIATRIC HEART-LUNG RECIPIENTS By Era of Transplant Percentage of Transplants ISHLT 2009

43 J Heart Lung Transplant 2009;28: NUMBER OF CENTERS REPORTING PEDIATRIC HEART-LUNG TRANSPLANTS ISHLT NEED TO UPDATE 2009

44 J Heart Lung Transplant 2009;28: NUMBER OF CENTERS REPORTING PEDIATRIC HEART-LUNG TRANSPLANTS Stratified by center volume ISHLT 2009

45 J Heart Lung Transplant 2009;28: DIAGNOSIS IN PEDIATRIC HEART –LUNG TRANSPLANT RECIPIENTS (Transplants: ) Other includes Bronchiectasis, Alpha-1, and OB (non-ReTX) ISHLT 2009 NOTE: Unknown diagnoses were excluded from this tabulation.

46 J Heart Lung Transplant 2009;28: PEDIATRIC HEART-LUNG TRANSPLANTS: AGE DISTRIBUTION BY LOCATION Transplants between January 2000 and June 2008 ISHLT 2009

47 J Heart Lung Transplant 2009;28: PEDIATRIC HEART-LUNG TRANSPLANTS: DIAGNOSIS DISTRIBUTION BY LOCATION Transplants between January 2000 and June 2008 ISHLT 2009

48 J Heart Lung Transplant 2009;28: PEDIATRIC HEART-LUNG TRANSPLANTS: DONOR AGE DISTRIBUTION BY LOCATION Transplants between January 2000 and June 2008 ISHLT 2009

49 J Heart Lung Transplant 2009;28: PEDIATRIC HEART-LUNG TRANSPLANTATION Kaplan-Meier Survival By Diagnosis (Transplants: January 1990 – June 2007) ISHLT 2009

50 J Heart Lung Transplant 2009;28: PEDIATRIC HEART-LUNG TRANSPLANTATION Kaplan-Meier Survival (Transplants: January June 2007) ISHLT 2009

51 J Heart Lung Transplant 2009;28: PEDIATRIC HEART-LUNG TRANSPLANTATION Kaplan-Meier Survival by Era (Transplants: January June 2007) ISHLT 2009

52 J Heart Lung Transplant 2009;28: PEDIATRIC HEART-LUNG TRANSPLANTATION Kaplan-Meier Survival by Era (Transplants: January June 2007) Conditional on Survival to 1 Year ISHLT 2009

53 J Heart Lung Transplant 2009;28: PEDIATRIC HEART-LUNG TRANSPLANT RECIPIENTS: Cause of Death (Deaths: January June 2008) CAUSE OF DEATH 0-30 Days (N = 37) 31 Days - 1 Year (N = 49 ) >1 Year - 3 Years (N = 45 ) >3 Years - 5 Years (N = 31 ) >5 Years (N = 43) BRONCHIOLITIS 2 (4.1%)21 (46.7%)10 (32.3%)8 (18.6%) ACUTE REJECTION 2 (4.1%)1 (2.2%) LYMPHOMA 2 (4.1%)1 (2.2%)1 (3.2%)2 (4.7%) MALIGNANCY, OTHER 1 (3.2%) CMV 2 (4.1%) INFECTION, NON-CMV 6 (16.2%)16 (32.7%)4 (8.9%)1 (3.2%)14 (32.6%) GRAFT FAILURE 16 (43.2%)9 (18.4%)14 (31.1%)14 (45.2%)11 (25.6%) CARDIOVASCULAR 2 (5.4%)3 (6.1%)1 (2.2%)2 (6.5%)3 (7.0%) TECHNICAL 6 (16.2%) ISHLT 2009

54 J Heart Lung Transplant 2009;28: PEDIATRIC HEART-LUNG TRANSPLANT RECIPIENTS: Cause of Death (Deaths: April June 2008) CAUSE OF DEATH0-30 Days (N = 31) 31 Days - 1 Year (N = 35) >1 Year - 3 Years (N = 39) >3 Years - 5 Years (N = 27) >5 Years (N = 43) BRONCHIOLITIS1 (2.9%)18 (46.2%)9 (33.3%)8 (18.6%) ACUTE REJECTION1 (2.9%)1 (2.6%) LYMPHOMA2 (5.7%)1 (2.6%)1 (3.7%)2 (4.7%) MALIGNANCY, OTHER1 (3.7%) CMV1 (2.9%) INFECTION, NON-CMV4 (12.9%)12 (34.3%)4 (10.3%)1 (3.7%)14 (32.6%) GRAFT FAILURE14 (45.2%)6 (17.1%)11 (28.2%)12 (44.4%)11 (25.6%) CARDIOVASCULAR2 (6.5%)2 (5.7%)1 (2.6%)1 (3.7%)3 (7.0%) TECHNICAL4 (12.9%) ISHLT 2009

55 J Heart Lung Transplant 2009;28: PEDIATRIC HEART-LUNG TRANSPLANT RECIPIENTS: Relative Incidence of Leading Causes of Death (Deaths: April June 2008) ISHLT 2009


Download ppt "J Heart Lung Transplant 2009;28: 989-1049 HEART-LUNG TRANSPLANTATION Overall ISHLT 2009."

Similar presentations


Ads by Google