1. SPATIAL DISCRIMINATION IN A T MAZE Trials to criterion BL/6 strain FVB strain ACQUISITION AND REVERSAL 0 10 20 30 40 50 60 Day 1Day 2Day 3Day 4Day 5Day 16 0 10 20 30 40 50 60 Day 1Day 2Day 3Day 4Day 5Day 16 60 0 10 20 30 40 50 Day 17Day 18Day 19Day 20 REPETITION 0 10 20 30 40 50 60 Day 17Day 18Day 19Day 20 A B C D

2. PERSEVERATIVE RESPONSE Perseverative errors 0 1 2 3 4 5 Day 2Day 3Day 4Day 5Day 16 0 1 2 3 4 5 Day 2Day 3Day 4Day 5Day 16 SPATIAL DISCRIMINATION IN A T MAZE BL/6 strainFVB strain RETENTION Retention delay % of correct responses 30 40 50 60 70 80 90 100 5 min24 hrs chance Retention delay 30 40 50 60 70 80 90 100 5 min24 hrs chance AB

3. DISCRIMINATION SPATIALE DANS UN LABYRINTHE EN T KO WT

4. DISCRIMINATION SPATIALE DANS UN LABYRINTHE EN T Erreurs perseveratives % de reponses correctes WT KO RETENTION 30 40 50 60 70 80 90 100 5 mn24 h chance Delai 30 40 50 60 70 80 90 100 5 mn24 h chance Delai Souche FVBSouche BL/6