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Dr Martin Smith Consultant Paediatric Neurologist Birmingham Children’s Hospital Dyskinetic Cerebral Palsy Greater Manchester Cerebral Palsy Network Meeting.

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Presentation on theme: "Dr Martin Smith Consultant Paediatric Neurologist Birmingham Children’s Hospital Dyskinetic Cerebral Palsy Greater Manchester Cerebral Palsy Network Meeting."— Presentation transcript:

1 Dr Martin Smith Consultant Paediatric Neurologist Birmingham Children’s Hospital Dyskinetic Cerebral Palsy Greater Manchester Cerebral Palsy Network Meeting 7 th November 2013

2 Chorea Athetosis Dystonia Intermittent; irregular Sustained postures Unsustained; flowing

3 Abnormal (usually high) muscle tone Weakness Impaired motor control

4 Dystonia Involuntary sustained or intermittent muscle contractions cause twisting and repetitive movements, and/or abnormal postures ‘Inserted postures and movements’

5 Chorea Greek, khoreia, meaning dance Involuntary, random (appearing), quick jerking movements Abrupt, non-repetitive and arrthymic Variable frequency and intensity

6 Athetosis Described by Hammond (1871) as “an inability to retain the fingers and toes in any position they might be placed, and by their continual motion” Hyperkinetic movement disorder characterised by involuntary writhing movements of the distal extremities and peri-oral muscles Some consider athetosis as a variant of dystonia

7 Symmetrical high signal in ventro- lateral thalamus and putamen following acute near total hypoxic- ischaemic injury in term infant

8 Treatments Orthosis e.g. lycra, second skin etc Medication for dystonia e.g. Trihexiphenidyl, Clonidine, L-Dopa Medication for chorea e.g. Levitarecetam, Valproate, Tetrabenzine Intra-thecal Baclofen Deep brain stimulation Stem cells ???

9 Thanks to Birmingham colleagues past and present Dr Hardev Pall Dr Manju Kurian Dr Stuart Green Thanks to children and families for allowing me to use videos for teaching and education


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