1. BriSCEV Survey ’08-09’ Ascertainment: all UK BriSCEV members (’07-’08) received survey (n=70) Follow up e-mails and phone calls One response only requested / unit 15 units responded (no non - member response i.e. likely neurophysiology units) 83% response

2. responding centres routinely offer 15/15 ERG & pattern reversal VEP 14/15 PERG 13/15 pattern onset VEPs 12/15 EOGs 5/15 mfERGs, though number of respondents waiting kit 2/15 mfVEP 1/15 steady state step VEP Imaging: 6/15 centres acquire or access OCT, 2 of these 6 also do additional imaging BriSCEV Survey Results #0 available tests

3. Px numbers 8825 –2800 –1400 –700 (55% in 3 responding centres) BriSCEV Survey Results 1 px nos and staff number of people number of patients/annum 56 staff 24/56 PhD (42%) Nb number days testing vary 7/15 part time staff mix 5 medical physics 5 ophthalmology 2 optometry 1 clin neurophysiol 2 stand alone patients/annum 0 500 1000 1500 2000 2500 3000 123456789101112131415 number of staff involved 0 2 4 6 8 10 12 123456789101112131415 nos tests/annum 0 1000 2000 3000 4000 5000 123456789101112131415

4. Normative ERG data –13 centres provided Ganzfeld ERG data –2 centres have no data Of 13 giving data 1 centre purchased from Coupland 1 centre supplemented by crackERG 6 using median data 2 using mean data Rest not stated 8/13 using DTL, of these 5/9 sub-palpebral BriSCEV Survey Results # 2 mean & median data ERG norms

5. Range flash luminances: 0.005-0.1 (blue & white) BriSCEV Survey Results # 2 mean & median data ERG norms: Rod driven b-wave Amplitude Flash luminance Time to peak rod driven b-wave 0 50 100 150 200 250 300 350 123456789101112131415 amplitude (uV) rod driven flash luminance 0 0.02 0.04 0.06 0.08 0.1 0.12 123456789101112131415 b time to peak 0 20 40 60 80 100 120 123456789101112131415 ms DTL GF GF SKIN DTL DTL DTL GF GF DTL DTL GF DTL DTL

6. flash range 1.5 -11.5, mode 3 scot standard flash b-wave amp 0 100 200 300 400 500 600 700 123456789101112131415 amplitude (uV) scotopic standard flash 0 5 10 15 123456789101112131415 scot b time to peak 0 10 20 30 40 50 60 123456789101112131415 ms Amplitude Flash luminance Time to peak BriSCEV Survey Results # 2 mean & median data ERG norms: scot. Std flash b-wave DTL GF GF SKIN DTL DTL DTL GF GF DTL DTL GF DTL DTL

7. Amplitude Flash luminance Time to peak scot standard a-wave (uV) 0 50 100 150 200 250 300 350 400 123456789101112131415 scotopic standard flash 0 5 10 15 123456789101112131415 scot standard a time to peak 0 5 10 15 20 123456789101112131415 ms BriSCEV Survey Results # 2 mean & median data ERG norms: scot. Std flash a-wave DTL GF GF SKIN DTL DTL DTL GF GF DTL DTL GF DTL DTL

8. flash range 1.5 – 8cd.s.m 2, background 17 -70 cd/m 2 phot b-wave amp 0 50 100 150 200 250 123456789101112131415 amp (uV) phot flash luminance 0 1 2 3 4 5 6 7 8 9 123456789101112131415 phot b time to peak 0 5 10 15 20 25 30 35 40 123456789101112131415 ms Amplitude Flash luminance Time to peak BriSCEV Survey Results # 2 mean & median data ERG norms: phot std a-wave DTL GF GF SKIN DTL DTL DTL GF GF DTL DTL GF DTL DTL

9. phot a-wave amplitude 0 10 20 30 40 50 60 123456789101112131415 amplitude (uV) phot flash luminance 0 1 2 3 4 5 6 7 8 9 123456789101112131415 phot a time to peak 0 5 10 15 20 25 30 123456789101112131415 ms Amplitude Flash luminance Time to peak BriSCEV Survey Results # 2 mean & median data ERG norms: phot std a-wave DTL GF GF SKIN DTL DTL DTL GF GF DTL DTL GF DTL DTL

10. Previous graphs for the mean and median, 8 centres also gave range and these data are plotted for each condition. BriSCEV Survey Results #3 range data rod driven Extreme range 84-527µV, 46-113ms nb age mix mean range amp: min 120 µ V mid 202µV max 361µV mean range time to peak min 71ms mid 86ms max 102ms gf sp sub-palpebral dtl gf gold foil sp

11. Scot std a-wave data BriSCEV Survey Results #3 range data scot standard flash Extreme range 54-525µV (400µV), 9-23ms nb age mix & flash luminance mean range amp: min 124µV mid 212µV max 287µV mean range time to peak min 13ms mid 15ms max 22ms sp gf

12. Scot std b-wave data BriSCEV Survey Results #3 range data scot standard flash Extreme range 142-866µV, 33-61ms nb age mix & flash luminance mean range amp: min 225µV mid 361µV max 545µV mean range time to peak min 39ms mid 47ms max 55ms sp gf

13. Phot a-wave data, one data set missing BriSCEV Survey Results #3 range data phot standard flash Extreme range 2-79µV, 11-17ms nb age mix mean range amp: min 16µV mid 33µV max 51µV mean range time to peak min 12ms mid 14ms max 16ms sp gf

14. Phot b-wave data, BriSCEV Survey Results #3 range data phot standard flash Extreme range 33-336µV, 22-34ms nb age mix mean range amp: min 70µV mid 129µV max 199µV mean range time to peak min 27ms mid 29ms max 32ms 0 100 200 300 400 12345678 phot b-wave amplitude min mid max sp gf

15. µ V ms b-wave rod-driven 0 10 20 30 40 50 60 70 80 90 4 11 µ V ms a-wave scot std µ V ms b-wave scot std µ V ms a-wave phot std µ V ms b-wave phot std There is concordance in skin ERG data between two centres nb std 3 vs 2.51cd.s.m 2 and phot background 70 vs 30 cd.m 2 Photopic ERGs Scotopic ERGs BriSCEV Survey Results #4 skin & ganzfeld data

16. 14 respondents: 14/14 centres seen children 5-16yrs, range less 1/week – 8/week 13/14 centres see children 1-5yrs range 1/month -16/week 11/14 centres seen children 1yr and underrange 2/month – 11/week Under 1 yr – 11 centres 10/11 centres use skin ERGs and only rarely use sedation/ anaesthesia 1/11 uses routine anaesthesia and sedation 1yr and uses corneal electrodes. They see the smallest number under 1/ annum 2/12 centres see more than 4 children under 1yrs /wk (both children centres) 1-5yrs – 13 centres 12/13 centres seeing 1-5yr olds use skin electrodes mainly, but introduce corneal electrodes, 1/13 uses corneal electrodes only – smallest number of 1-5yr olds Aged 5-16yrs - 14 centres Corneal electrodes are mostly used, but 8/14 centres would occasionally use skin electrodes Sedation: very rare but occasionally used by 3/14 centres includes 2 responding children hospitals use under anaesthesia in theatre BriSCEV Survey Results #5 paediatric data

17. Duration of test typical ERG 60 minutes PERG 15 minutes VEPs 10-45 minutes EOG 30 - 60 minutes mfERG 15-60 minutes mfVEP 25-80 minutes Others many tests one session e.g. 105 minutes ERG PVEP mfERG and OCT 90 minutes to do all tests needed freq of appts /day 0 1 2 3 4 1234567 number of appts/ day BriSCEV Survey Results #6 appointment times

18. Where next ? Can we combine data : no Can we use others data: mostly no Can we identify close data sets: yes Could national collaborations occur: yes With proviso than have common luminances to start with – calibration stimulators Investigate outliers, but outliers by definition are our normal limits!! –standardise eye OUTCOME UK TRAVELLING EYE PROJECT 2010 ISCEV small project grant funding