Every gene Every gene involved, directly and/or indirectly in energy formation (ATP)
Every gene Every gene involved, directly and/or indirectly in energy formation (ATP) obesity gene is an obesity gene.
Every gene Every gene involved, directly and/or indirectly in energy formation (ATP) Probably several hundred genes. obesity gene is an obesity gene.
efficient To find efficient drugs against obesity, lipidemia and type II diabetes through innovative a completely innovative approach. Our goal
Our Goal: Efficiency - Our target is specific - Its function is not redundant - Efficiency - No side effect
Slimness Slimness gene as new target for the treatment of obesity, lipidemia and type II diabetes
Is there any genetic disease in which the phenotype is : lean, low cholesterol and low triglycerides ? Our strategy A single gene with a tissue specific expression
From a particular case (slim phenotype) To treat general obesity cases
Advantages of our anti-obesity target versus competitor targets Specificity - Specific function - Tissue specific expression (intestine) Non Redundant
Current Situation A first therapeutic target validated Patent pending A list of potential hit compounds obtained by virtual screening Patent pending A patented HTS assay design for our first target
Next steps In-vitro and cellular testing hit compounds In-vivo testing for best leads Clinical Study phase I first Q1 2004 HTS for new hit compounds Transgenic rabbits dominant/negative and/or RNAi Polymorphism of other candidat genes Enhance the value of the company and reduce the risks to investors in order to attract Venture Capital
Slimness genes allow you to eat without gaining weight.