Presentation on theme: "Detector R&D and Cancer Care Barbara Camanzi. NDI Kick-Off Meeting, 10/12/102/18 Outline Why cancer Detector R&D projects for cancer care: imaging."— Presentation transcript:
NDI Kick-Off Meeting, 10/12/102/18 Outline Why cancer Detector R&D projects for cancer care: imaging and dosimetry The Futures Programme and the STFC Cancer Care Strategy Summary
Barbara Camanzi NDI Kick-Off Meeting, 10/12/103/18 The challenge of cancer in UK Cancer is the leading cause of mortality in people under the age of 75. 1 in 4 people die of cancer overall 293k people/year diagnosed with cancer, 155k people/year die from cancer Incidence of cancer is rising due to: 1. Population ageing 2. Rise in obesity levels 3. Change in lifestyle Cancer 3 rd largest NHS disease programme
Barbara Camanzi NDI Kick-Off Meeting, 10/12/104/18 Detector R&D projects for cancer care
Barbara Camanzi NDI Kick-Off Meeting, 10/12/105/18 The technological challenges The challenge of radiotherapy from the patient end Make sure that the right dose is delivered at the right place = improved dosimetry + improved imaging The challenge of early diagnosis “See” smaller tumours = improved imaging New advanced technologies desperately needed for dosimetry and imaging
Barbara Camanzi NDI Kick-Off Meeting, 10/12/106/18 The imaging challenge The requirements for new imaging systems: 1. More accurate, more quantitative and highly repeatable imaging 2. Imaging during treatment: organ movement (breathing), patient set-up, tumour shrinkage 3. Image smaller lesions (early diagnosis) 4. Treatment specific requirements (for ex. Bragg position in proton/light ion therapy) The answer: higher spatial resolution, higher linearity, lower noise, less drift, faster imaging
Barbara Camanzi NDI Kick-Off Meeting, 10/12/107/18 Positron Emission Tomography 18 F labelled glucose given to patients: e + annihilates in two back-to-back 511 keV seen by a ring of detectors Conventional PET: straight line-of- response, annihilation point calculated probabilistically 511 keV
Barbara Camanzi NDI Kick-Off Meeting, 10/12/108/18 Time-Of-Flight PET (TOF-PET) TOF-PET scanner: 1. Time difference between signals from two crystals measured 2. Annihilation point along line-of-response directly calculated Goal: 100 ps timing resolution (ideally 30 ps and below) = 3 cm spatial resolution (ideally sub-cm) Advantages: higher sensitivity and specificity, improved S/N Technology needed: fast scintillating materials and fast photon detectors
Barbara Camanzi NDI Kick-Off Meeting, 10/12/109/18 The TOF-PET project Development of a TOF-PET imaging system: 1.Fast scintillating materials (LYSO and LaBr 3 ) 2.SiPMs Seed funding from NEAT (NIHR) and CLIK for feasibility study. Ended: 03/10 Currently: 1.FP7 funding (ENVISION project) through Oxford: one post-doc, Dr Mahfuza Ahmed 2.2 PhD students: Paola Avella (Surrey) and Ed Leming (Sussex) 3.No money for equipment, computer licences, etc.
Barbara Camanzi NDI Kick-Off Meeting, 10/12/1010/18 The dosimetry challenge The requirements for new dosimeters: 1. Measure dose at tumour site and not at skin 2. Measure total dose (including during imaging procedures) 3. Measure in real-time and not long time after treatment 4. System easy to use The answer: in-vivo dosimetry
Barbara Camanzi NDI Kick-Off Meeting, 10/12/1011/18 The in-vivo dosimetry project Development of an in-vivo dosimetry system: 1.RadFET dose sensors 2.RFID wireless communication system 3.Powering system 4.Associated electronics (ASIC) CFI funding for ASIC design. End: 04/11 Scientific coordinator of large consortium (~15 partners). Looking at FP7 funding
Barbara Camanzi NDI Kick-Off Meeting, 10/12/1012/18 The Futures Programme and the STFC Cancer Care Strategy
Barbara Camanzi NDI Kick-Off Meeting, 10/12/1013/18 The Futures Programme Created in January 2009 Goal: to increase STFC impact in meeting the four global challenges (CSR 2007): 1.Energy 2.Environment 3.Healthcare 4.Security Creates opportunities = Identify unmet needs + Match them to in-house skills and expertise and technologies
Barbara Camanzi NDI Kick-Off Meeting, 10/12/1014/18 What Futures does and doesn’t do Futures does: 1. Provide strategic advice to STFC 2. Initiate projects and programmes 3. Increase STFC contribution to RCUK cross- council programmes 4. Build strategic partnerships Futures doesn’t: 1. Bring only external income 2. Provide short-term solutions 3. Try to be perfectly symmetrical across the four global challenges
Barbara Camanzi NDI Kick-Off Meeting, 10/12/1015/18 The Futures Team Catherine Ewart, Head of the Team Nicholas Harrison, Energy Kevin Smith, Environment Gareth Derbyshire, Healthcare Barbara Camanzi, Cancer Care Bryan Edwards, Security Geoff McBride, Horizon Scanning
Barbara Camanzi NDI Kick-Off Meeting, 10/12/1016/18 The opportunity “By 2012 our cancer services can and should become not only among the best in Europe but among the best in the world.” “Everyone with a commitment to delivering world class cancer services should have a role in helping deliver this strategy.” From “Cancer Reform Strategy“, Department of Health http://www.dh.gov.uk/en/Publicationsandstatistics/Publications/PublicationsPolicyAndGuidance/dh_081006 STFC has in-house skills, expertise and technologies to be one of these everyone!
Barbara Camanzi NDI Kick-Off Meeting, 10/12/1017/18 The STFC Cancer Care Strategy Who will input to the STFC strategy: 1. Clinical world: oncologists, medical physicists.. 2. STFC staff 3. University groups 4. Industry Alliances with strategic partners: MRC, CRUK, etc.
Barbara Camanzi NDI Kick-Off Meeting, 10/12/1018/18 Summary One detector R&D imaging project underway: TOF-PET. Enough people working on it; but lack of money for equipment. One detector R&D dosimetry project at the proposal stage. Joined the Futures Team as of 01/09/10: to lead the development of STFC Cancer Care Strategy. The Futures Programme is wider than cancer care.