What is Life All About : Self-compiling & self-assembling Complementary surfaces Watson-Crick base pair (Nature April 25, 1953)
Life Science vs Computing Where do parasites come from? (computer & biological viral codes) Over $12 billion/year on computer viruses LoveBug Set dirtemp =3D fso.GetSpecialFolder(2) Set c =3D fso.GetFile(WScript.ScriptFullName) c.Copy(dirsystem&"\MSKernel32.vbs") c.Copy(dirwin&"\Win32DLL.vbs") c.Copy(dirsystem&"\LOVE-LETTER-FOR-YOU.TXT.vbs") regruns() html() spreadtoemail() listadriv() 20 M dead (worse than black plague & 1918 Flu) AIDS - HIV-1 Polymerase drug resistance mutations M41L, D67N, T69D, L210W, T215Y, H208Y PISPIETVPV KLKPGMDGPK VKQWPLTEEK IKALIEICAE LEKDGKISKI GPVNPYDTPV FAIKKKNSDK WRKLVDFREL NKRTQDFCEV
Concept Computers Organisms Instructions Program Genome Bits 0,1 a,c,g,t Stable memory ROM,Disk,tape DNA Active memory RAM RNA Processing CPU/Compiler enzyme/Ribosome Editing Editor tRNA Environment Sockets,people Water,salts,heat I/O AD/DA proteins Monomer Minerals Nucleotide Polymer chip DNA,RNA,protein Replication Cut/Paste DNA replication Sensor/In scanner Chem/photo receptor Exciting Life ??
of RNA-based life: C,H,N,O,P Useful for many species: Na, K, Fe, Cl, Ca, Mg, Mo, Mn, S, Se, Cu, Ni, Co, Si Elements
X-linked recessive disorder. The inheritance pattern is shown for a recessive gene on the chromosome X, designated in bold. Male XY (normal) FemaleX (normal) Female XX (normal) Female XX (normal) Male XY (normal) Male XY (affected)
Protein Folding Problem (Sequence 3D Structure) 1 Protein folding is thermodynamically determined (Anfinsen’s thermodynamic principle ) Protein + Environment 2. Protein folding is a reaction imvolving other interacting molecules (Principle of molecular interactions) Protein + Chaperonins +….
Bioinformatics : A Long Journey (How far are we away from knowing the God ??) Sequence to exon 80% [Laub 98] Exons to gene (without cDNA or homolog) ~30% [Laub 98] Gene to regulation ~10% [Hughes 00] Regulated gene to protein sequence 98% [Gesteland ] Sequence to secondary-structure ( , ,c) 77% [CASP] Secondary-structure to 3D structure 25% [CASP] 3D structure to ligand specificity ~10% [Johnson 99] Expected accuracy overall ~ = 0.8*.3*.1*.98*.77*.25*.1 =.0005 ?