1. CavinKare Research Centre
Presentation - R&D
CavinKare Research Centre
CavinKare Pvt. Ltd.
Confidential Document : Access to Approved Users Only

2. Objectives of R&D To contribute to the business objectives
of CKPL by developing innovative, cost
effective and superior products and
processes
To make R&D a self-supporting / profit
making activity by creating and
developing Intellectual Property through
out-licensing or national / international
collaborations

3. Product Portfolio Personal Care : Hair, Skin and Home
Shampoo Chik, Nyle, Meera, Karthika
Hair Wash Powder Meera, Karthika
Hair Dye Indica
Hair Oil Meera, Nyle
Cream / Lotion Fairever, FE Mantra, Nyle CC & ML
Talc, Deo & Dab-on Spinz
Toilet Bowl Cleaner Tex
Mosquito Coil Dishoom
Foods : Ready-to-eat
Pickles Chinni’s, Ruchi
Spices Chinni’s
Vermicelli Chinni’s
Sweets Ruchi
Dry Fruits Chinni’s Moments Snack Bar Chinni’s Cruncho

4. R&D - Relationships Personal Care (Domestic Business)
Salon Business (Trends in Vogue)
International Business
Personal Care (Domestic Business)
Foods (Domestic Business)

5. R&D Strategy for Competitive Advantage
To Provide Superior Products at Affordable Price Points
Superior Formulation (sensory experience; delivery of benefit; care)
Discovery of new ingredients (exclusivity; superior performance)
Developing new / improved processes (cost effectiveness)
Developing new technology (exclusivity; superior performance)
Strengthening biology (developing capability; studying new pathways)
Leveraging IPR (drafting claims; analysis; competitive intelligence)

6. R&D Set-up & Facilities

7. CRC at a Glance Buildings = 2 Total Build-up Area = 30000 Ft2
Annual Expenditure of Turnover
Personnel Strength = 40 (Projected 2007)
(Technical)
Educational Status
Number
Doctorates 8
Masters 24
Graduates 4
Total 36
Personnel Status
(As on Aug 07)

8. Organisation Chart
( )

9. Major Equipments (Analytical) Gas Chromatograph HPLC TLC Scanner
UV Spectrophotometers
Moisture analyser (Infrared, Karl-Fischer)
Viscometer
Mexameter
Skin Testing Equipment
(sebum level, moisture, pH, elasticity, TEWL)
Hair Testing Equipment
(tensile prop., combability, volume)
Reflection Spectrophotometer

10. Major Equipments (Infrastructural) Stability chambers
Rotary evaporator
Clean air workbench
Cold room
Ultra-low Temp Fridge (-70°C)
Washing Machine
Soxhlet extractor
Autoclave
Tray Driers
Cell culture facility
Tergetometer
Triple Roll Mill
Contra-Rotary Mixer
Sigma Mixer
Simplex Plodder
Ribbon Mixer
Horizontal Mixer
Mini Soap Plodder
Rotary coating pan
Generator Backup
Effluent Treatment Plant

11. Information / Knowledge Management
Library
Number of Books = 806
Number of Periodicals Subscribed = 35
Number of Databases Subscribed = 3
(CTFA – online; CTFA-IRDB; STN; Delphion)
Number of Libraries to which affiliated = 5
(CLRI, IIT, IISc., BCL & MGR Medical Univ)
Membership of Other Organisations / = 2
Professional Bodies (CTFA(USA), BIS)

12. Information / Knowledge Management
Information Systems
A fully networked facility with a central control (server)
based on ‘thin client’ technology and a Document
Management System
Sample Tracking for all analytical operations
including work flow

13. R&D Programme

14. R&D Programme : Basic Research
Extraction, isolation and characterisation of bioactive / functional
compounds from natural sources
Synthesis, characterisation and new process development of
ingredients for personal care products
Screening of natural products for microbiocidal activities with an
emphasis on preservation of products and functional delivery
(e.g. antidandruff)
Characterisation of major ingredients presently used in personal
care products to optimise their performance

15. R&D Programme : Product Development
Development of Formulations and Processes for Safe & Effective
Products with emphasis on functional delivery in the areas of -
Hair Care Products
Skin Care Products
Cleaning and Hygiene Products
Continuous optimisation and development of new formulation
to keep the product cost under control
Development of Spices, Vermicelli and Ready-to-Eat Products
Such as Pickles, Nut based products (like peanuts, cashew),
Snack foods and Traditional Sweets

16. Outline of R&D Activities

17. (Selection of Ingredients)
Product Development
(Selection of Ingredients)
Focus on Benefits
Delivery of Promise (Claims substantiation)
Superior Sensory Experience
Gentle / Safe

18. Product Development : Shampoo
Typical Ingredients
Typical Analysis

19. Sensory Evaluation for Products

20. Product Support Identifying / Developing New Ingredients
(biochemistry, microbiology & chemistry)
Developing Specifications & Methods (Measurement)
Developing New Processes (Chemistry)
Demonstrating Efficacy (Biochemistry, Claim substantiation)
Facing the Challenge of Contamination (Microbiology)
Information / Knowledge Management (Library)
Facilitating Activities (IT services, administration etc)

21. Claim Substantiation Safety evaluation of Products e.g. Irritancy test
Developing study protocol
Identifying clinical investigator
Preparing documents like
Consent Form,
Investigator Declaration Form,
Product Brief, Assessment Form etc
Recruitment of volunteers
Coordination and conduct of the study
Data collation, Analysis and Report submission

22. Hair Oil - Study Highlights
(Claim Substantiation)
Note : No. of hairs obtained is the number of hair collected during combing in the clinic

23. Evaluating a Skin Lightening Cream
(Claim Substantiation)
Reduction in Average Mexameter Reading = 248
% Reduction = %
Assessing Reduction in Pigmentation
Volunteer Perception of Efficacy

24. Biochemical Assays Mildness Assay (Shampoo) Skin Lightening Assay
Zein assay
Collagen swelling
pH rise
Skin Lightening Assay
Tyrosinase inhibition assay
DOPA autooxidation inhibition assay
Anti-aging Assay
Elastase inhibition asssay
Antiinflammatory Assay
Soyabean lipooxygenase inhibition assay
Antioxidant Assay
DPPH radical scavenging assay
Deoxyribose degradation assay
Superoxide Dismutase assay

25. Cell Based Assays Skin Lightening 1. Melanin assay
2. Tyrosinase inhibition assay
Oxidative stress Cytotoxicity Assay
Cytotoxicity / Proliferation MTT assay
Mildness Assay (Shampoo) 1. Cytotoxicity assay
2. RBC lysis assay
Cell lines Available :
Melanocyte (melanoma) B16-F10, B16-F1 & G361
Fibroblast (normal) NIH / 3T3
Keratinocyte (carcinoma) A431
General (cancer) HeLa
Primary cell lines Fibroblasts & Keratinocytes

26. Chemistry
Extraction, isolation and characterisation of bioactive / functional
Compounds from natural sources (skin lightening, antioxidants, antiaging etc.)
Synthesis, characterisation and new process development of
Ingredients for personal care products
Screening of natural products for microbiocidal activities with an
Emphasis on preservation of products and functional delivery
(e.g. antidandruff)
Development of natural hair colours

27. Chemical Process Oleochemicals Secondary Surfactants
Monoethanol amides
Amidopropyl betaines
Also useful as Thickening Agent

28. Microbiology Study of anti-microbial efficacy (MIC, synergy etc)
Selection of suitable preservatives for products
Estimation of microbial load during development
Preservative Challenge Test
Screening natural products for antidandruff activity
Evaluation of competitive products

29. Measurements Total No. Assays = >190 Major Responsibilities
Analysis of Own Products
Analysis of Competitor Products
Setting up Specifications
Interfacing with Regulatory Authorities
(BIS, Drug Controllers)
Major Responsibilities
Sample
Tracking

30. Thank You
Confidential Document : Access to Approved Users Only