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Confidential Document : Access to Approved Users Only CavinKare Research Centre CavinKare Pvt. Ltd. Presentation - R&D Confidential Document : Access to.

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Presentation on theme: "Confidential Document : Access to Approved Users Only CavinKare Research Centre CavinKare Pvt. Ltd. Presentation - R&D Confidential Document : Access to."— Presentation transcript:

1 Confidential Document : Access to Approved Users Only CavinKare Research Centre CavinKare Pvt. Ltd. Presentation - R&D Confidential Document : Access to Approved Users Only

2 Objectives of R&D To make R&D a self-supporting / profit making activity by creating and developing Intellectual Property through out-licensing or national / international collaborations To contribute to the business objectives of CKPL by developing innovative, cost effective and superior products and processes

3 Confidential Document : Access to Approved Users Only Pickles Chinnis, Ruchi SpicesChinnis VermicelliChinnis Sweets Ruchi Dry FruitsChinnis Moments Snack BarChinnis Cruncho Foods : Ready-to-eat Personal Care : Hair, Skin and Home ShampooChik, Nyle, Meera, Karthika Hair Wash PowderMeera, Karthika Hair DyeIndica Hair OilMeera, Nyle Cream / LotionFairever, FE Mantra, Nyle CC & ML Talc, Deo & Dab-on Spinz Toilet Bowl CleanerTex Mosquito CoilDishoom Product Portfolio

4 Confidential Document : Access to Approved Users Only R&D - Relationships Salon Business (Trends in Vogue) International Business Personal Care (Domestic Business) Foods (Domestic Business)

5 Confidential Document : Access to Approved Users Only Discovery of new ingredients (exclusivity; superior performance) Developing new / improved processes (cost effectiveness) Developing new technology (exclusivity; superior performance) Strengthening biology (developing capability; studying new pathways) Leveraging IPR (drafting claims; analysis; competitive intelligence) Superior Formulation (sensory experience; delivery of benefit; care) R&D Strategy for Competitive Advantage To Provide Superior Products at Affordable Price Points

6 Confidential Document : Access to Approved Users Only R&D Set-up & Facilities

7 Confidential Document : Access to Approved Users Only CRC at a Glance Total Build-up Area = Ft 2 Buildings = 2 Annual Expenditure of Turnover Personnel Strength= 40 (Projected 2007) (Technical) Educational Status Number Doctorates8 Masters24 Graduates4 Total36 Personnel Status (As on Aug 07)

8 Confidential Document : Access to Approved Users Only Organisation Chart ( ) Head – R&D Formulation Development (Foods) Pickles & Spices Snacks & Value Added Products Food Preparation Formulation Development (PHC) Hair Care I (Liquid Hair Wash) Skin Care Hair Care II (Powders & Colours) Home & Hygiene Perfumery Claims Substantiation Measurement Product Analysis (PHC) Product Performance Product Analysis (Foods) Chemistry Biochemistry & Cell Biology Microbiology Admin & Commercial Library (Knowledge Management) Secretarial & Coordination

9 Confidential Document : Access to Approved Users Only Gas Chromatograph HPLC TLC Scanner UV Spectrophotometers Moisture analyser (Infrared, Karl-Fischer) Viscometer Mexameter Skin Testing Equipment (sebum level, moisture, pH, elasticity, TEWL) Hair Testing Equipment (tensile prop., combability, volume) Reflection Spectrophotometer Major Equipments (Analytical)

10 Confidential Document : Access to Approved Users Only Stability chambers Rotary evaporator Clean air workbench Cold room Ultra-low Temp Fridge (-70°C) Washing Machine Soxhlet extractor Autoclave Tray Driers Major Equipments (Infrastructural) Cell culture facility Tergetometer Triple Roll Mill Contra-Rotary Mixer Sigma Mixer Simplex Plodder Ribbon Mixer Horizontal Mixer Mini Soap Plodder Rotary coating pan Generator Backup Effluent Treatment Plant

11 Confidential Document : Access to Approved Users Only Library Number of Books= 806 Number of Periodicals Subscribed= 35 Number of Databases Subscribed= 3 (CTFA – online; CTFA-IRDB; STN; Delphion) Number of Libraries to which affiliated= 5 (CLRI, IIT, IISc., BCL & MGR Medical Univ) Membership of Other Organisations /= 2 Professional Bodies (CTFA (USA), BIS) Information / Knowledge Management

12 Confidential Document : Access to Approved Users Only Information / Knowledge Management A fully networked facility with a central control (server) based on thin client technology and a Document Management System Sample Tracking for all analytical operations including work flow Information Systems

13 Confidential Document : Access to Approved Users Only R&D Programme

14 Confidential Document : Access to Approved Users Only Extraction, isolation and characterisation of bioactive / functional compounds from natural sources Synthesis, characterisation and new process development of ingredients for personal care products Screening of natural products for microbiocidal activities with an emphasis on preservation of products and functional delivery (e.g. antidandruff) Characterisation of major ingredients presently used in personal care products to optimise their performance R&D Programme : Basic Research

15 Confidential Document : Access to Approved Users Only Development of Formulations and Processes for Safe & Effective Products with emphasis on functional delivery in the areas of - Hair Care Products Skin Care Products Cleaning and Hygiene Products Development of Spices, Vermicelli and Ready-to-Eat Products Such as Pickles, Nut based products (like peanuts, cashew), Snack foods and Traditional Sweets Continuous optimisation and development of new formulation to keep the product cost under control R&D Programme : Product Development

16 Confidential Document : Access to Approved Users Only Outline of R&D Activities

17 Confidential Document : Access to Approved Users Only Focus on Benefits Delivery of Promise (Claims substantiation) Superior Sensory Experience Gentle / Safe Product Development (Selection of Ingredients) Product Development (Selection of Ingredients)

18 Confidential Document : Access to Approved Users Only Typical Analysis Product Development : Shampoo Typical Ingredients

19 Confidential Document : Access to Approved Users Only Sensory Evaluation for Products

20 Confidential Document : Access to Approved Users Only Product Support Identifying / Developing New Ingredients (biochemistry, microbiology & chemistry) Developing New Processes (Chemistry) Developing Specifications & Methods (Measurement) Demonstrating Efficacy (Biochemistry, Claim substantiation) Information / Knowledge Management (Library) Facilitating Activities (IT services, administration etc) Facing the Challenge of Contamination (Microbiology)

21 Confidential Document : Access to Approved Users Only Claim Substantiation Safety evaluation of Products e.g. Irritancy test Developing study protocol Identifying clinical investigator Preparing documents like Consent Form, Investigator Declaration Form, Product Brief, Assessment Form etc Recruitment of volunteers Coordination and conduct of the study Data collation, Analysis and Report submission

22 Confidential Document : Access to Approved Users Only Note : No. of hairs obtained is the number of hair collected during combing in the clinic Hair Oil - Study Highlights (Claim Substantiation)

23 Confidential Document : Access to Approved Users Only Evaluating a Skin Lightening Cream (Claim Substantiation) Volunteer Perception of Efficacy Reduction in Average Mexameter Reading = 248 % Reduction = % Assessing Reduction in Pigmentation

24 Confidential Document : Access to Approved Users Only Biochemical Assays Mildness Assay (Shampoo) 1.Zein assay 2.Collagen swelling 3.pH rise Skin Lightening Assay 1.Tyrosinase inhibition assay 2.DOPA autooxidation inhibition assay Anti-aging Assay Elastase inhibition asssay Antiinflammatory Assay Soyabean lipooxygenase inhibition assay Antioxidant Assay 1.DPPH radical scavenging assay 2.Deoxyribose degradation assay 3.Superoxide Dismutase assay

25 Confidential Document : Access to Approved Users Only Skin Lightening 1. Melanin assay 2. Tyrosinase inhibition assay Oxidative stress Cytotoxicity Assay Cytotoxicity / Proliferation MTT assay Mildness Assay (Shampoo) 1. Cytotoxicity assay 2. RBC lysis assay Cell Based Assays Cell lines Available : Melanocyte (melanoma) B16-F10, B16-F1 & G361 Fibroblast (normal)NIH / 3T3 Keratinocyte (carcinoma)A431 General (cancer)HeLa Primary cell lines Fibroblasts & Keratinocytes

26 Confidential Document : Access to Approved Users Only Extraction, isolation and characterisation of bioactive / functional Compounds from natural sources (skin lightening, antioxidants, antiaging etc.) Screening of natural products for microbiocidal activities with an Emphasis on preservation of products and functional delivery (e.g. antidandruff) Chemistry Synthesis, characterisation and new process development of Ingredients for personal care products Development of natural hair colours

27 Confidential Document : Access to Approved Users Only Chemical Process Oleochemicals 1.Monoethanol amides 2.Amidopropyl betaines Secondary Surfactants Also useful as Thickening Agent

28 Confidential Document : Access to Approved Users Only Microbiology Screening natural products for antidandruff activity Preservative Challenge Test Selection of suitable preservatives for products Study of anti-microbial efficacy (MIC, synergy etc) Evaluation of competitive products Estimation of microbial load during development

29 Confidential Document : Access to Approved Users Only Measurements Total No. Assays= >190 Analysis of Own Products Analysis of Competitor Products Setting up Specifications Interfacing with Regulatory Authorities (BIS, Drug Controllers) Major Responsibilities Sample Tracking

30 Confidential Document : Access to Approved Users Only


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