1. Problem: How can you investigate inheritance patterns in families.
Materials: Paper, Pen/Pencil

2. Case Study 1
Joshua and Bella have a son named Ian. Ian has been diagnosed with cystic fibrosis.
Joshua and Bella are both healthy
Bella’s parents are both healthy
Joshua’s parents are both healthy
Joshua’s sister, Sara has cystic fibrosis.

3. Create a pedigree that shows all of the family members.
Shade in the circles or squares representing individuals who have cystic fibrosis.
Determine the genotype of each family member starting with Ian. Write it next to each person.
N= dominant normal allele
n= recessive allele (cystic fibrosis)

4. Case Study 2
The father, Li, has a skin condition (purple dots). The mother, Mai, does not.
Li and Mai’s first child, a girl named Gemma, has the same skin condition as Li.
Mai’s sister, Lu has the same skin condition, but Mai’s parents do not.
Li has one brother, Chen whose skin is normal, and one sister, Mulan who has the skin condition.
Li’s mother has the skin condition. His father does not.

5. Create a pedigree that shows all of the family members.
Shade in the circles or squares representing individuals who have the skin condition.
Determine the genotype of each family member.
H= Healthy skin
h=dots

6. How does this activity relate to the topics that you and your classmates discussed in chapter 4? Why?

7. Daniel has tongilitis, his wife Semone does not.
Daniel’s mother and father, Tyreek and Cheyenne, are both healthy.
Daniel’s sister, Danielle, is healthy. Their brother John has tongilitis.
Semone’s mother, Daisha, is healthy. Her father Malik has tongilitis.
Daniel and Semone have three children. Noelani and Jaisha are both healthy, but Kaseem has tongilitis.