Presentation on theme: "7.4 Human Genetics and Pedigrees"— Presentation transcript:
17.4 Human Genetics and Pedigrees Set up Cornell Notes on pg. 81Topic: 7.4 Human Genetics and PedigreesEssential Questions:1. NO EQ7.4 Human Genetics and Pedigrees2.1 Atoms, Ions, and MoleculesKEY CONCEPT A combination of methods is used to study human genetics.
2KEY CONCEPT A combination of methods is used to study human genetics.
3Inheritance of many human traits is complex The basic principles of genetics are the same in all sexually reproducing organisms.Inheritance of many human traits is complexSingle-gene traits are important in understanding human genetics.Ex: widow’s peakWidow’s peak
4A pedigree is a chart for tracing genes in a family. Phenotypes are used to infer genotypesPlease copy on Pg. 80Pedigree Key:Boxes = malesCircles = femalesShaded = they show the traitWhite = does not show traitHalf shaded = carrier(Carrier= Only for recessive disorders)
5How many females are in this family? How many carriers?How many children were in generation two?How many offspring in generation three are affected by the trait?Pg. 80Generation 1Generation 2Generation 3Generation 4
6How many females are in this family? 11 How many carriers? 7 How many children were in generation two? 5How many offspring in generation three are affected by the trait? 2Generation 1Generation 2Generation 3Generation 4
7Autosomal Dominant Trait- Many family members will show the trait in the pedigree Widow’s peakNo Widow’s peak
8On pg. 81, please create this pedigree and answer the following questions: Jamie and Joe married in Joe was homozygous dominant for a Widow’s Peak, while Jamie did not have a Widow’s Peak. They had two children: A son named Kyle and a daughter named Marie.Kyle married a woman who had no Widow’s Peak.Marie never married.Kyle and his wife had three children: Two boys and a girl.Do Kyle and Marie have Widow’s Peaks?What percent of Kyle’s children can we expect to have Widow’s Peaks?What percent of Kyle’s children can we expect to have NO Widow’s Peaks?
9? ? ? Joe Jamie LL x ll 100% Ll LL ll Marie Kyle Ll ll Ll Ll x ll 50% Ll and 50% ll???Yes, Kyle and Marie have Widow’s Peaks50% should have Widow’s Peaks50% should have NO Widow’s Peaks
10Autosomal Recessive Disorders will show up if carriers mate, may skip a few generations before reappearing. Only a few, will show the trait/disorderOn pg. 81, Fill in the genotypes of this incomplete pedigree. Shade if necessary.aa
11On pg. 81, Fill in the genotypes of this incomplete pedigree On pg. 81, Fill in the genotypes of this incomplete pedigree. Shade if necessary.aa
12Albinism is an autosomal recessive disorder. Fill in the genotypes. Shade if necessaryAaaaProb.?AaaaAaAaAa or AAAa??aaaaAaAA or Aa
13Pg. 80Mary and Joe were married in Both Mary and Joe were carriers for a fatal recessive disorder called Cystic Fibrosis. They had three children: A son named Pete who was a carrier, a son named Charles who was not a carrier and did not have the disease, and a girl named Isabel who died from Cystic Fibrosis. Pete married a woman who was homozygous dominant. Pete and his wife are worried about having a child with Cystic Fibrosis. Should they worry? What are the chances of any of their children having Cystic Fibrosis? Carriers?
14? ? ? Joe Mary Ff Ff Isabel Charles Pete Ff FF FF ff FF x Ff O%- No chance of any of their children having the disorder50% will be carriers???
15Females can carry sex-linked genetic disorders. Males (XY) express all of their sex linked genes.Expression of the disorder depends on which parent carries the allele and the sex of the child.XY
16Sex-linked traits: More males will show their sex-linked traits because they do not have another X to mask the disorder Ex: Color blindnessmalesfemales
17X-linked Color Blindness- Recessive XMXM= Normal XMXm= carrier XmXm= CBXMY= NormalXmY= CBXmYXMXmXMXmXMXmXMXmXMYXmYOn pg. 80, Fill in the genotypes of this incomplete pedigree. Shade if necessary.?XmYXmYXMXM or XMXm
18A karyotype is a picture of all chromosomes in a cell. X Y
19Karyotypes can show changes in chromosomes. deletion of part of a chromosome or loss of a chromosomelarge changes in chromosomesextra chromosomes or duplication of part of a chromosome
20In down syndrome a person has an extra copy of chromosome 21. In Klinefelter’s syndrome a male has an extra X (XXY).