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Histo-blood group antigens as allo- and/or autoantigens Nydegger, U.E. and Flegel, W.A. University of Bern, Switzerland and University of Ulm, Germany.

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Presentation on theme: "Histo-blood group antigens as allo- and/or autoantigens Nydegger, U.E. and Flegel, W.A. University of Bern, Switzerland and University of Ulm, Germany."— Presentation transcript:

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2 Histo-blood group antigens as allo- and/or autoantigens Nydegger, U.E. and Flegel, W.A. University of Bern, Switzerland and University of Ulm, Germany - 4th International Congress Autoimmunity Budapest 2004

3 Blood group antigens assigned to systems Slide courtesy of D. Anstee 1997

4 World Wide Web sites for Blood Group Antigens Nydegger UE, Flegel WA 2004

5 Blood group antigens as autoantigens I/i P Kell Lewis MN Cold agglutinins Donath-Landsteiner antibodies Warm-reactive autoantibodies Helicobacter pylori –molecular mimicry Treponema pallidum –molecular mimicry Nydegger UE, Flegel WA 2004

6 Blood groups on the RBC Gerbich Knops Kell Lutheran LW Duffy MNS ABO Ii Rh Indian Cromer Yt Diego Slide courtesy of E. Sjoberg-Wester

7 Chemical basis of the ABO and Lewis blood group system ß-D-Gal(1-3)ß-D-GlcNAc Type 1 Precursur Substance  -L-Fuc(1-2) ß-D-Gal(1-3)ß-D-GlcNAc H type 1A type 1  -D-GalNAc(1-3) [  -L-Fuc(1-2)] ß-D-Gal(1-3)ß-D-GlcNAc B type 1  -D-Gal(1-3) [  -L-Fuc(1-2)] ß-D-Gal(1-3)ß-D-GlcNAc Le b  -L-Fuc(1-2) ß-D-Gal(1-3)[  -L-Fuc(1-4)]ß-D-GlcNAcß-D-Gal(1-3)[  -L-Fuc(1-4)]ß-D-GlcNAc Le a Nydegger UE, Flegel WA 2004

8 Disappearance of B and appearance of H Antigen Koestner et al. Lancet 363(2004)1523 B type O type O type Monoclonal antibodies Lectin Months post transplant Controls

9 ABOI heart allograft: follow up for 44 months post transplant B Antigen H Antigen Post transplant: months Nydegger UE, Flegel WA 2004

10 Conclusion Numerous blood group system antigens –occur not only on red blood cells –but are also expressed on cells of various other tissues Hence, autoantibodies –known to impinge on red cells –are also reactive for various other tissues Blood group antigens –might be more frequently involved as tissue autoantigens –and should be more often considered in this context Nydegger UE, Flegel WA 2004


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