1. Histo-blood group antigens as allo- and/or autoantigens
Nydegger, U.E. and Flegel, W.A.
University of Bern, Switzerland and University of Ulm, Germany -
4th International Congress Autoimmunity Budapest 2004

2. Blood group antigens assigned to systems
Slide courtesy of D. Anstee 1997

3. World Wide Web sites for Blood Group Antigens
Nydegger UE, Flegel WA 2004

4. Blood group antigens as autoantigens
I/i P
Kell
Lewis MN
Cold agglutinins
Donath-Landsteiner antibodies
Warm-reactive autoantibodies
Helicobacter pylori
molecular mimicry
Treponema pallidum
Nydegger UE, Flegel WA 2004

5. Blood groups on the RBC Lutheran ABO Ii Gerbich Knops Diego Yt Duffy
MNS
Cromer
Indian LW
Kell Rh
Slide courtesy of E. Sjoberg-Wester

6. Chemical basis of the ABO and Lewis blood group system
Type 1 Precursur Substance
Leb
-L-Fuc(1-2) ß-D-Gal(1-3)[-L-Fuc(1-4)]ß-D-GlcNAc
ß-D-Gal(1-3)[-L-Fuc(1-4)]ß-D-GlcNAc
Lea
B type 1
-D-Gal(1-3) [-L-Fuc(1-2)] ß-D-Gal(1-3)ß-D-GlcNAc
A type 1
-D-GalNAc(1-3) [-L-Fuc(1-2)] ß-D-Gal(1-3)ß-D-GlcNAc
-L-Fuc(1-2) ß-D-Gal(1-3)ß-D-GlcNAc
H type 1
Nydegger UE, Flegel WA 2004
ß-D-Gal(1-3)ß-D-GlcNAc

7. Disappearance of B and appearance of H Antigen
Koestner et al. Lancet 363(2004)1523
Months post transplant
Controls
B type O type O type
Monoclonal antibodies Lectin

8. ABOI heart allograft: follow up for 44 months post transplant
B Antigen
Nydegger UE, Flegel WA 2004
H Antigen
Post transplant: months

9. Conclusion Numerous blood group system antigens Hence, autoantibodies
occur not only on red blood cells
but are also expressed on cells of various other tissues
Hence, autoantibodies
known to impinge on red cells
are also reactive for various other tissues
Blood group antigens
might be more frequently involved as tissue autoantigens
and should be more often considered in this context
Nydegger UE, Flegel WA 2004