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Research Institute for Medicinal Plants and Herbs FAO Expert Roundtable BUDAPEST / Budakalasz 2012.04.2-5 Jozsef Peter PALLOS CEO RIMPH - PannonPharma.

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Presentation on theme: "Research Institute for Medicinal Plants and Herbs FAO Expert Roundtable BUDAPEST / Budakalasz 2012.04.2-5 Jozsef Peter PALLOS CEO RIMPH - PannonPharma."— Presentation transcript:

1 Research Institute for Medicinal Plants and Herbs FAO Expert Roundtable BUDAPEST / Budakalasz Jozsef Peter PALLOS CEO RIMPH - PannonPharma

2 RIMPH-PannonPharma  RIMPH member of the group of pharma companies:  PannonPharma Pharmaceuticals Ltd R+D, mid scale Manufacturing of solid dosage drugs  Trigon Biotech Ltd -  Clongen – Biopharma - Ltd  RIMPH - GYNKI vertically integrated company for medicinal plants to herbal medicines

3 >100 years of tradition >100 years of tradition  1884 Páter Béla the founder of medicinal plant research Kolozsvar  1915 Irk Károly established the HR Establishment for Medicinal Plants  1924 Kabay János started the poppy opiates extraction R+D  1925 Augustin Béla developped the medicinal plant improvement, and qualification system, as the model of the european medicinal plant regulations1951  1934 Békésy Miklós started thef claviceps purpurea R+D activities  1951 Institute for mMedicinal Plants - GyógynövényKutató Intézet  1957-től Tétényi Péter started new varieties, improvents > 50 officially tested end approved varieties  1969 Budakalasz site opening  1970 official medicinal plant state control activities, release of batches (plants, drugs, extracts etc) for medicinal use  1982 joint venture company of Hungarian (big )pharmaceutical companies  2003 Nature Conservation Area of Chemotaxonomy Botanical Garden

4 Janos Kabay (1896–1936) Invented the o pium free world Developped the Extraction process of alkaloids from poppy straw - first patent y1925 extraction from green plant - final patent y1931 extraction from dried poppy capsule - first pre INCB audit ever y1935 League of Nations -UN predecessor

5 World class researchers of RIMPH  Augustin Béla  Száhlender Károly  Kabay János  Kelp Ilona  Békésy Miklós  Kuntz János  Boros Ádám  Szathmáry Géza  Máthé Imre  Nyiredy Szabolcs  Dános Béla  Bernáth Jenő  Kiniczky Márta  Tyihák Ernő  Szatmáry Miklós  Máthé Imre jnr  Máthé Ákos

6 First ever medicinal plant state control system ( s) - y1922 Publishing of Guidelines for wild crfting, collection of medicinal plants „Útmutatás a vadontermő gyógynövények gyűjtésére” (Augustin-Darvas, Gyógy- és Ipari Növényforgalmi Iroda Kiadó Budapest, 1922, 199 pps.) -y1922 Publishing of Guidelines for cultivation of plant for medicinal and chemical use „Gyógy- és vegyipari növények termesztése” (Augustin-Darvas-Schneider, FM kiadás, Pátria Nyomda, Vác, 1922, 176 pps.) FM kiadás, Pátria Nyomda, Vác, 1922, 176 pps.) - y1923 control and use of state seal in export release - y1934 extension of control to field activities (cultivation, crafting, processing on site) This system was kept in force until years of 90s No control exists in recent years. No control exists in recent years.

7 RIMPH - GYNKI today as is RIMPH - GYNKI the vertically integrated company from medicinal plants research to finished products as herbal medicines involving: research, development, genebanking, varieties improvements, identification and QC analysis laboratories, extraction of APIs, manufacturing of finished pharmaceuticals, research, development, genebanking, varieties improvements, identification and QC analysis laboratories, extraction of APIs, manufacturing of finished pharmaceuticals, registration of own new products

8 Mission  Research on plants for medicinal use  New added value products  New varieties  New technologies in agriculture of MAPs  New API extraction technologies  11 new medicinal products 4 new varieties in pipeline

9 Herbal succes elements  New varieties (efficient, safe)  Motivated farmers  Skilled integrators  High tech processors  Market driven companies  Responsible authorities  Reasonable regulation  Supportive state admin

10 There are markets for sure - The y2050 vision - More people (?10 Bn) % / year market growth - example the poppy

11 Example -poppy alkaloids the growth is evident

12 Poppy the wonder chemical plant

13 Opium centuries are down

14 Morfin, Tebain are up

15 Morfin growth

16 Tebain growth

17 Aussi success story

18 Hungary lost markets


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