1. GLP-1 and gastrin combination therapy increases pancreatic insulin content (A) and β-cell mass (B) in NOD mice.
GLP-1 and gastrin combination therapy increases pancreatic insulin content (A) and β-cell mass (B) in NOD mice. Pancreata were removed from acutely diabetic NOD mice before and after 3 weeks of the treatments indicated plus an additional 5 weeks after treatments were stopped or sooner if the mice were killed because of severe diabetes as shown in Fig. 1. NOD-scid mice provide normal values for pancreatic insulin content (A) and β-cell mass (B). Values are means ± SE. *P < 0.05, **P < 0.01 vs. pretreatment values for the numbers of mice shown in parentheses.
Wilma L. Suarez-Pinzon et al. Diabetes 2008;57:
©2008 by American Diabetes Association