1. Improvement of insulin sensitivity by treatment of the annexin A1 receptor agonist in HFD mice.
Improvement of insulin sensitivity by treatment of the annexin A1 receptor agonist in HFD mice. Mice were fed an NCD or HFD for 10 weeks, and then treated with 200 μg/head of WKYMVm or a vehicle control for 5 days. A, Western blot of annexin A1 in the plasma of vehicle-treated NCD or HFD mice. The lower graph shows densitometric analysis of annexin A1. ANXA1 indicates annexin A1. B, Glucose tolerance test for the treatment groups. *p < 0.05, between HFD (Vehicle) and HFD (WKYMVm). C, Fasting plasma glucose concentrations in each treatment group. *p < 0.05, between NCD (Vehicle) and HFD (Vehicle). D, Fasting plasma insulin concentrations in each treatment group. *p < 0.05, between NCD (Vehicle) and HFD (Vehicle). #p < 0.05, between HFD (Vehicle) and HFD (WKYMVm). All data in the figure are presented as mean ± S.E.; n = 3∼5 per group; *, #p < 0.05, in Student's t test or in one-way ANOVA.
Jong Hyuk Yoon et al. Mol Cell Proteomics 2015;14:
© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.