1. Ranked as one of Americas best in cancer care by U.S.News & World Report, including our top rankings in digestive disorders, urology and neurology. Over 250 cancer specialists and researchers More than 350 active cancer clinical trials Annually serves more than 26,000 cancer patients

2. Taussig Cancer Institute Strengths Nationally recognized staff Multi-disciplinary clinics Translational research efforts Educational programs State-of-the-art technology

3. We have entered into a very dynamic period in oncology with breathtaking developments in our understanding of the basic biology of cancer and a dramatic increase in the number of novel anticancer agents. The job going forward is to integrate translational science and clinical research with optimal and compassionate patient care. Robert Dreicer, MD Chairman, Department of Solid Tumor Oncology

4. Did you know? Our multidisciplinary clinic for GI cancer incorporates close collaboration with a number of departments including: Gastroenterology Colorectal Surgery Interventional Radiology Radiation Oncology Patients are offered a wide variety of clinical trials, ranging from large randomized trials sponsored by the NCI to Cleveland Clinic local trials of experimental drugs.

5. The Renal Cell Carcinoma Program at the Cleveland Clinic Taussig Cancer Institute is a recognized international leader that provides best in class multidisciplinary care of kidney cancer patients. In conjunction with the Glickman Urological and Kidney Institute, the program has played a critical role in the development of practice-changing novel therapy. We will continue to innovate through translational clinical trials that advance both the science of kidney cancer and the clinical care of patients. Brian Rini, MD Department of Solid Tumor Oncology

6. Fully Certified Staff Physicians are board-certified in Therapeutic Radiology by the American Board of Radiology Senior medical physicists are certified by the American Board of Radiology and/or the American Board of Medical Physics Therapist staff are certified by the American Registry of Radiologic Technologists Registered nursing staff are certified by the Oncology Nursing Society Dosimetrists are certified by the Medical Dosimetrist Certification Board

7. Lung cancer is managed by a team of experts, including medical and radiation oncologists, thoracic surgeons, and pulmonary physicians who work hand in hand. We focus on innovative multidisciplinary approaches for the treatment of lung cancer. Tarek Mekhail, MD Department of Solid Tumor Oncology

8. Cancer Consult An Update for Physicians from Cleveland Clinic Taussig Cancer Institute Includes articles on the latest advances in basic science and clinical research. Recent articles include: The State of Myelodysplastic Syndrome (MDS) Treatment G1P3 Antagonizes TRAIL-induced Apoptosis in Human Myeloma Cells Translating Acute Leukemia Research from Bench-to-Bedside

9. "We have entered the era of molecular targeting in cancer therapy. Optimal management of the disease requires an intimate knowledge of cancer biology and therapeutic targets, the development of creative ways of delivering drugs to those targets, and well-trained research oriented clinicians dedicated to providing cutting edge therapy." Timothy Spiro, MD Chair, Department of Regional Oncology

10. Physicians and researchers in the Taussig Cancer Institute pioneered the use of early chemotherapy after initial surgery to improve cure rates in bladder and prostate cancer. They also have developed novel anti-cancer drugs for patients with cancers of the prostate, bladder, testes, kidney and other tumors of the genitourinary system. Did you know?

11. We understand the importance of research and innovation in delivering the most current and best medical care to individuals with leukemia, lymphoma, and other hematological malignancies, but never lose sight of the fact that clinical excellence and compassion is our primary mission. Brian Bolwell, MD Chairman, Department of Hematologic Oncology and Blood Disorders

12. The Center for Hematology Oncology and Molecular Therapeutics at the Taussig Cancer Institute is investigating targeted therapies that will be helpful in improving treatments for renal carcinoma. This research extends advances made in clinical use of growth factor receptor inhibitors for renal carcinoma. Ernest Borden, MD Department of Solid Tumor Oncology

13. The real advantage of Gamma Knife ® radiosurgery compared to traditional surgery is that patients can go on with their lives. For a patient with cancer that is very important. John Suh, MD Chairman, Department of Radiation Oncology

14. Did you know? Recently Taussig Cancer Institute introduced a Late Effects Clinic for cancer survivors. This multidisciplinary clinic helps to address health problems that can arise as late effects of successful cancer treatment.

15. At Cleveland Clinic all patients with head and neck cancer are approached by a multidisciplinary team from head and neck surgery, radiation and medical oncology, dentistry, speech pathology, physical therapy and dietary services. Aggressive, cutting-edge treatments, many developed at Cleveland Clinic, have led to successful organ preservation and cure in the vast majority of patients with these formerly devastating malignancies." David Adelstein, MD Department of Solid Tumor Oncology

16. Visit us on the web: www.clevelandclinic.org/cancer Get up-to-date information from Cleveland Clinic right from your computer. Learn about some of the latest innovations and techniques from the Taussig Cancer Institute. View recent physician publications.

17. The science of palliative and supportive therapies is integral to the advancement of anti-tumor therapies. Without them many of the present day advances would not be possible. Research in symptom management and supportive care is equally important now, because patients are living longer as a result of disease modifying chemotherapy, targeted tyrosine kinase inhibitors and monoclonal antibodies. Mellar Davis, MD Department of Solid Tumor Oncology

18. In our multidisciplinary clinics, subspecialists bring their expertise to bear on specific tumor types and aspects of treatment and recovery. Medical, surgical and radiation oncologists collaborate closely with pathologists, radiologists, oncology nurses and social workers. These interactions enhance effective communication and optimize the options for individual patients with complex problems. Did you know?

19. At Cleveland Clinic we seek to individualize the treatment of breast cancer patients, based on sound scientific research. Patients are offered state-of-the- art and investigational therapies based on their individual tumor's biology. G. Thomas Budd, MD Department of Solid Tumor Oncology

20. Cleveland Clinic is consistently ranked as one of Americas top hospitals by U.S.News & World Report

21. "The cutting edge is an effective tool only in the hands of someone experienced with cutting. Our breadth of expertise is the hand that guides our cutting edge therapies." Matt Kalaycio, MD Director, Chronic Leukemia and Myeloma Program, Department of Hemotologic Oncology and Blood Disorders

22. Active research in anti-cancer drug discovery and development, combined with further refinement of treatment delivery approaches, will continue to improve our level of service and the resulting outcomes. Derek Raghavan, MD, PhD Chairman, Taussig Cancer Institute Chairman, Cancer Division, Cleveland Clinic

23. Isolation of serotonin, a key factor in hypertension (1940s) Development of no-touch colorectal surgery (1950s) First coronary angiography (1958) Development and refinement of coronary bypass surgery (1967) First minimally invasive aortic heart valve surgery (1996) First successful larynx transplant (1999) Discovery of first gene linked to juvenile macular degeneration (2000) Discovery of first gene linked to coronary artery disease (2003) Worlds first use of surgical robot for spinal surgery (2005) First minimally invasive combined mitral valve surgery and ablation of atrial fibrillation (2006) Pioneered the use of deep brain stimulation to successfully treat profound depression, Tourette syndrome and OCD (2006) Numerous other breakthroughs and innovations have happened at Cleveland Clinic in fields ranging from basic science to brain surgery. Cleveland Clinic Innovations

24. Cleveland Clinics Lerner Research Institute is one of three NHLBI-funded Specialized Centers for Clinically Oriented Research (SCCOR) in Thrombosis. We are excited about the progress to date and are anticipating many clinically significant discoveries. Roy L. Silverstein, MD Chair, Department of Cell Biology Cleveland Clinic Lerner Research Institute

25. Cleveland Clinic Annual Statistics Patient Care 3,458,509... Total Visits 163,000.... Admissions 112,000.... Surgical Cases 1,808...... Physicians and Scientists Education 1,170...... Residents and Fellows 624........Medical Students Research $244M.... Total Research Funding

26. Treating patients with stage IV head and neck cancer is challenging because of their poor prognosis and difficult tolerance, but the combined chemoradiotherapy approach offers excellent survival and organ preservation. Jerrold Saxton, MD Department of Radiation Oncology