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Progress Against Breast Cancer. 1970–1979 Progress Against Breast Cancer 1970–1979 1971: More limited mastectomy proven effective for early-stage breast.

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Presentation on theme: "Progress Against Breast Cancer. 1970–1979 Progress Against Breast Cancer 1970–1979 1971: More limited mastectomy proven effective for early-stage breast."— Presentation transcript:

1 Progress Against Breast Cancer

2 1970–1979

3 Progress Against Breast Cancer 1970–1979 1971: More limited mastectomy proven effective for early-stage breast cancer

4 Progress Against Breast Cancer 1970–1979 1974: Doxorubicin active against advanced breast cancer

5 Progress Against Breast Cancer 1970–1979 1975: Adjuvant chemotherapy increases cure rates for early-stage breast cancer

6 Progress Against Breast Cancer 1970–1979 1977: Estrogen receptor status proven to predict risk of breast cancer recurrence 1977: Many women can opt for breast-conserving surgery 1977: Breakthrough drug, tamoxifen, receives initial FDA approval Late 1970s: Growing use of mammography saves lives

7 Progress Against Breast Cancer 1980–1989

8 Progress Against Breast Cancer 1980–1989 1986: Tamoxifen reduces breast cancer recurrence

9 Progress Against Breast Cancer 1990–1999

10 Progress Against Breast Cancer 1990–1999 Mid-1990s: BRCA1 and BRCA2 gene mutations linked to increased breast cancer risk 1994, 2008: Taxanes emerge as vital chemotherapy option for breast cancer

11 Progress Against Breast Cancer 1990–1999 Mid-1990s: Bone-building drugs help reduce complications of breast cancer and its treatment

12 Progress Against Breast Cancer 1990–1999 1996: Sentinel lymph node biopsy introduced to assess breast cancer spread

13 Progress Against Breast Cancer 1990–1999 1998: Oral chemotherapy drug, capecitabine, approved for advanced breast cancer 1998: Drug therapy can reduce breast cancer risk in women at high risk 1998: Chemotherapy before surgery helps more women benefit from breast-conserving treatment 1998: First targeted anti-breast cancer drug, trastuzumab (Herceptin), has major impact on care

14 Progress Against Breast Cancer 2000–Present

15 Progress Against Breast Cancer 2000–Present 2000: High-dose chemotherapy plus stem cell transplant does not improve breast cancer survival 2000: Breast cancer subtypes identified

16 Progress Against Breast Cancer 2000–Present 2002–2004: Novel genetic tests help guide breast cancer therapy

17 Progress Against Breast Cancer 2000–Present 2003: Higher density, shorter term chemotherapy improves breast cancer survival

18 Progress Against Breast Cancer 2000–Present 2004: New class of drugs, aromatase inhibitors, introduced 2004: Adding new drug, gemcitabine, extends survival for some women with advanced breast cancer 2004: Docetaxel helps reduce breast cancer recurrence

19 Progress Against Breast Cancer 2000–Present 2005: Low-fat diet and regular exercise may reduce risk of breast cancer recurrence 2005: Digital mammography more accurate than standard mammography in younger women

20 Progress Against Breast Cancer 2000–Present 2006: Screening, treatment key to declining U.S. breast cancer mortality 2006: Tamoxifen and raloxifene equally effective for preventing invasive breast cancer 2006: Many breast cancer survivors experience fatigue

21 Progress Against Breast Cancer 2000–Present 2007: Lapatinib approved for patients whose HER2-positive breast cancer no longer responds to trastuzumab 2007: MRI screening recommended for women at high risk of breast cancer 2007: Declining breast cancer incidence linked to lower use of hormone replacement therapy 2007: Shorter course of radiation therapy is as effective as less frequent radiation therapy for early-stage breast cancer

22 Progress Against Breast Cancer 2000–Present 2007: First in new class of drugs approved for advanced breast cancer that resists other treatments 2008–2010: Bevacizumab (Avastin) approved for advanced breast cancer

23 Progress Against Breast Cancer 2000–Present 2009: Preventive surgery confirmed to reduce breast and ovarian cancer risk in women with BRCA gene mutations 2009: Standard chemotherapy is an option for older women 2009: PARP inhibitors show promise for difficult-to- treat breast cancers

24 Progress Against Breast Cancer 2000–Present 2010: Targeted drug denosumumab helps prevent common bone-related complications in advanced breast cancer 2010: Removing fewer lymph nodes for some breast cancer patients does not impair survival 2010: New chemotherapy drug improves survival for advanced breast cancer 2011: Aromatase inhibitors cut breast cancer risk among women at high risk

25 Progress Against Breast Cancer 2000–Present 2012: Two targeted drugs together are more potent than one for HER-2 positive breast cancer 2012-2013: Armed-antibody drug improves survival for women with resistant HER2 positive cancers

26 Progress Against Breast Cancer Five-Year Survival Source: National Cancer Institute

27 Progress Against Breast Cancer Mortality Source: National Cancer Institute

28 Progress Against Breast Cancer New Cases Source: National Cancer Institute

29 Visit CancerProgress.Net for an interactive timeline of progress against a range of common cancers CancerProgress.Net is a project of the American Society of Clinical Oncology, which represents nearly 30,000 physicians who treat people with cancer and research new cures


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