1. A L I M E N T A T I O N A G R I C U L T U R E E N V I R O N N E M E N T AERES September 17th, 2009 Collaborative research, intellectual property and technology transfer

2. A L I M E N T A T I O N A G R I C U L T U R E E N V I R O N N E M E N T AERES September 17th, 2009 Direction de la Valorisation DV INRA Launched in 2001, directly depending on the general board of INRA. An original integrated economical model, active since 2003 : dynamic balance between the revenues of royalties collected by two private subsidaries INRA Transfert Inc and Agri Obtentions Inc and the expenses invested by INRA for the protection of the intellectual property, the incentive measurements for the financial return to innovative scientists, collective return to the scientific units, and financing of the services ordered by INRA and achieved by its subsidaries. A unique management integrated by DV INRA for the two INRA units DV UCPI and DV DPE and the two subsidaries IT and AO. A double network of skills for the negociation of contracts : public partnership in the 21 regional centers, private partnership in the 14 scientific departments.

3. A L I M E N T A T I O N A G R I C U L T U R E E N V I R O N N E M E N T AERES September 17th, 2009 Direction de la Valorisation DV UCPI Missions of the unit DV UCPI : contract law and intellectual property. A legal staff of 15 skills higly specialized in the field of DV INRA, a critical mass of expertise( back office ) supporting the general activities of collaborative research achieved in the two previous networks ( front office ). A relevant expertise for the european consortium agreements, framework agreements with the private sector, finalization of complex contracts. The management of the following strategic portfolio of INRA : invention disclosures, patents, trademarks, databases and softwares. The management each month of the intellectual property national committee : recommandations and decisions for the filings, the extensions and the abandons.

4. A L I M E N T A T I O N A G R I C U L T U R E E N V I R O N N E M E N T AERES September 17th, 2009 Direction de la Valorisation DV DPE Missions of the unit DV DPE : stimulating and encouraging the partnership with private companies. 8 skills located in the west of France, launched in 2003. Expertise in the use of ICT dedicated to the internal communication with the scientists and the external dissemination of our results towards our partners. Economical and industrial survey to stimulate our strategic private partnerships. A national mission for the coordination of our collaborative research implemented within the network of the french regional clusters « Pôles de compétitivité ». Launching in 2008 of the network of our Phd students supported by industry. Annual reporting and follow up of the indicators in the field of DV.

5. A L I M E N T A T I O N A G R I C U L T U R E E N V I R O N N E M E N T AERES September 17th, 2009 « En direct des labos » et « Live from the labs » two electronic free of charge newsletters for our socio-economic partners 4380 partners have subscribed in France…. and 360 outside France www.inra.fr/en_direct_des_laboswww.international.inra.fr/live_from_the_labs Aims and objectives : Providing our private partners, through a professional and attractive tool, with the researches conducted and the results achieved in INRA, Meeting the industrial needs and stimulating the demand of research, Establishing relationships between researchers and private companies in France and Europe, Facilitating the cooperation with the best INRA scientific teams.

6. A L I M E N T A T I O N A G R I C U L T U R E E N V I R O N N E M E N T AERES September 17th, 2009 Collaborative research with industry technology transfer process Research contracts with the private companies Research projects on own funds Proof of concept and development of projects Pre seed of life science projects Licenses Start up Contract research projects: European projects, ANR,... Intellectual Property 205 families of patent applications 163 softwares or databases 56 trademarks 508 Certificats dObtention Végétale 234 contracts with private companies 9.9 M funding from private companies 234 contracts with private companies 9.9 M funding from private companies Filing of 15 to 20 proposals of european project each year Management of 12 european projects coordinated by INRA

7. A L I M E N T A T I O N A G R I C U L T U R E E N V I R O N N E M E N T AERES September 17th, 2009 ANNUAL FLOW OF NEW RESEARCH CONTRACTS WITH INDUSTRY, NEW PATENT APPLICATIONS AND NEW LICENSES

8. A L I M E N T A T I O N A G R I C U L T U R E E N V I R O N N E M E N T AERES September 17th, 2009 Open innovation and strategic private partnerships A wave of « framework agreements » to be consolidated or developed with the most important private international groups of our sectors. Stimulated and encouraged by the dynamics of open innovation and the incentive measurements of the french government ( « research tax credit » ) Animal health : PFIZER, MERIAL, CEVA, SCHERING INTERVET. Animal production and selection (AGENAE ) : EVIALIS, GLON SANDERS, UNCEIA,GRIMAUD. Food industry : NESTLE, DANONE, UNILEVER, PERNOD RICARD, BONGRAIN, BONDUELLE, LACTALIS, CHARAL. Ingredients : DANISCO, LALLEMAND, CH HANSEN, LESAFFRE, ROQUETTE. Seed industry (GENOPLANTE) : LIMAGRAIN, SYNGENTA, BCS. Green chemistry and energy ( FUTUROL) : TOTAL, IFP, DANISCO GENENCOR, DSM, TATE and LYLE, NOVOZYMES. Ecotechnologies : VEOLIA, SUEZ.

9. A L I M E N T A T I O N A G R I C U L T U R E E N V I R O N N E M E N T AERES September 17th, 2009 Open innovation and strategic private partnerships : future perspectives The most exciting and attractive developments for collaborative research to be prepared by INRA are expected in the following key sectors for the next ten years NUTRITION, FOOD FOR HEALTH ANIMAL HEALTH GREEN AND WHITE BIOTECHNOLOGIES FOR BIOMATERIALS, BIOPRODUCTS AND BIOENERGY. ECOTECHNOLOGIES

10. A L I M E N T A T I O N A G R I C U L T U R E E N V I R O N N E M E N T AERES September 17th, 2009 Agri obtentions : key figures Sales figures : 9 M Euros Staff : 42 persons Over 400 licence-holders 10 different species groups Head office : Guyancourt 2 Units : Guyancourt, Clermont- Ferrand Creation : October 1983 The Sustainable Agricultures Seed Breeder

11. A L I M E N T A T I O N A G R I C U L T U R E E N V I R O N N E M E N T AERES September 17th, 2009 Research contracts with the private companies Research projects funded on own support Pre seed of life science projects Licenses Start up Contract research projects: European projects, ANR,... Technology transfer of plant varieties Property Intellectual Property Proof of concept 1,127 licenses on varieties 4,6 M plant varieties royalty 4,6 M of varieties sales turnover

12. A L I M E N T A T I O N A G R I C U L T U R E E N V I R O N N E M E N T AERES September 17th, 2009 Floral ornamental species Cereals Pulses crop Forage and Grain corn Oil seed crops and fibre Forage crops Vegetables Fruit trees Forest trees Vines Agri obtentions : portfolio 10 different species groups - over 450 varieties Oil seed crops and fibre plants Oil seed rape: Sun, Bambin Lin seed : Everest, Eole, Hermès, Sunflower : Inbred lines Hybrids :Inoui, Inoll, Instinct Pulses crops Field bean : Disco, Mélodie,Diva Lupin : Lumen, Ludic Pea : Isard, Apollo, Galactic Cereals Oat : Fringante, Fervente Wheat : Ressor, Ephoros, Farandole, Durum wheat : Duriac, Duetto, Argeles Triticale : Collégial, Talentro, Maximal Forage crops Cocksfoot : Ludac, Lupré, Lude Alfalfa: Magali, Luzelle Red clover : Diadem, Diper Fodder beet : Colosse Fruit trees Apple : Ariane - Pear : Angelys Peach: Caprice - Cherry : Primula Apricot : Bergarouge Vegetables Garlic: Clerdor ®, Flavor® Shallot : Vigarmor Endigia : Isatis, Makis, Selkis Lens : Anicia Floral ornamental species Ranunculus : Friandine®, Pauline® Anemone : Marianne®, Tetranemone® Caryopteris : Le Grand Bleu Coteonaster : Belka Wine grape : Marselan, Caladoc Vines Forage and Grain corn Inbred lines Hybrids : Brait, Supermonark Elms: Lutèce® Poplar : A4A Forest trees

13. A L I M E N T A T I O N A G R I C U L T U R E E N V I R O N N E M E N T AERES September 17th, 2009 Sales figures : 8.4 M (5,9 M royalties, 0,9 M EU grants, 1,6 M INRA services) Staff : 24 persons (PHD in science, experience in enterprise, pay variable on objectives) Head office : Paris 5 Units : Clermont-Ferrand, Sophia-Antipolis, Rennes, Montpellier, Nantes Collaboration with SupAgro Montpellier, Agrocampus West and Clermont-Ferrand University Creation : February 2001 Setting up of Agro Biotech Accelerator in joint venture with Seventure (groupe NATEXIS) INRA Transfert: key figures

14. A L I M E N T A T I O N A G R I C U L T U R E E N V I R O N N E M E N T AERES September 17th, 2009 Research contracts with the private companies Research projects funded on INRA support Pre seed of life science projects Licenses Start up Contract research projects: European projects, ANR,... 320 license agreements 5.8 M of annual fees Technology transfer process Property Intellectual Property Proof of concept and development of projects. Prevalorisation program : providing funding directed towards development of INRA technology to a point suitable for commercialization 10 projects granted each year 600 K annual support

15. A L I M E N T A T I O N A G R I C U L T U R E E N V I R O N N E M E N T AERES September 17th, 2009 INRA LICENSES IT REVENUES

16. A L I M E N T A T I O N A G R I C U L T U R E E N V I R O N N E M E N T AERES September 17th, 2009 Research contracts with the private companies Research projects on own funds Licenses Start up Contract research projects: European projects, ANR,... Prove of concept and development of projects Pre seed of life science projects Start up development effort Intellectual Property 3 to 5 start up projects each year 40 start up created since 1999 250 jobs created and active in 2009

17. A L I M E N T A T I O N A G R I C U L T U R E E N V I R O N N E M E N T AERES September 17th, 2009 OVERVIEW OF THE YOUNG INNOVATIVE COMPANIES CREATED FROM INRA RESEARCH RESULTS

18. A L I M E N T A T I O N A G R I C U L T U R E E N V I R O N N E M E N T AERES September 17th, 2009 Plant A = CMS OGU INRA, male sterile Plant B : pollen giver harbouring fertility restorer Rfo gene X Canola or oilseed rape hybrid seed production (100% hybrid between A et B) Production of hybrid male fertile varieties with low glucosinolate content INRA patent on protoplast fusion (FR 8304298) INRA PATENT CMS OGU (FR 9011670) 2002 : ADVANTA patent WO9702737 assigned to INRA 2002 : crosslicence PIONEER and INRA (to avoid assert against INRA licensies 2002 : INRA patent EP 03291677,7 for low glucosinolate fertility restorer (useful in a complementary way to ease access to genetic material required for crossings) 42 non exclusive licenses 2008 3.8M royalties How INRA has built a worldwide leading patent pool through financial deals and cross license agreements… 2005 : INRA bought 3 patents kosena from MITSUBISHI (to avoid conflict risks)