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Endocrine Disruptors: What are they, and why should we care? httpwww.usgs.govthemesFS-189-97
The Endocrine System Hormones secreted into bloodstream from glands Conveys information throughout body Regulates metabolism, growth, reproduction, immune function, etc.
Examples of Human Hormones Testosterone Estrogen Growth hormone Insulin Thyroxine Adrenaline
Hormone Receptors Each hormone molecule fits a specific receptor protein Different cells, organs, have different receptors Hormones can target specific cells, organs via these receptors
Hormones target specific cells via their receptors
Different cells have different receptors
Endocrine disruptors: Molecules that interfere with endocrine system Naturally occurring or man-made Enter organisms via air, water, diet, skin Can cause problems with an organisms development, reproduction, immune system, etc.
Effects of Endocrine Disruptors Intersex characteristics: both male and female characteristics are present in the same fish; feminization of males Abnormal breeding cycles Impaired immune systems
http://pubs.usgs.gov/fs/fs-043-01/ http://snhs-plin.barry.edu/endocrine_disruptors.htm Cellular growth/tumors Abnormal development
Sources of Endocrine Disruptors: Drugs/medicines Pesticides Plasticizers Consumer products (plastic bottles, metal cans, detergents, cosmetics, toys, food)
Examples of Endocrine Disruptors DDT PCBs (polychlorinated biphenyls) BPA (bisphenol A) Phthalates
Dealing with Endocrine Disruptors Prevent exposure (laws, policy-making) Remove contaminants ???
Endocrine Disruptors and Frogs Limb development http://www.epa.gov/ncer/science/endocrine/ pdf/wildlife/r827398_gardiner-030105- final.pdf
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The endocrine system consists of a complex collection of glands that produce chemical messengers called hormones. Its function is to regulate metabolism,
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The Endocrine System. o Def: System of glands in various parts of the body that manufacture & secrete hormones into the bloodstream o hormones = chemical.
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