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Influence of lung injury on cardiac output measurement using transpulmonary ultrasound dilution: a validation study in neonatal lambs  S.L. Vrancken,

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Presentation on theme: "Influence of lung injury on cardiac output measurement using transpulmonary ultrasound dilution: a validation study in neonatal lambs  S.L. Vrancken,"— Presentation transcript:

1 Influence of lung injury on cardiac output measurement using transpulmonary ultrasound dilution: a validation study in neonatal lambs  S.L. Vrancken, W.P. de Boode, J.C. Hopman, M.G. Looijen-Salamon, K.D. Liem, A.F. van Heijst  British Journal of Anaesthesia  Volume 109, Issue 6, Pages (December 2012) DOI: /bja/aes297 Copyright © 2012 The Author(s) Terms and Conditions

2 Fig 1 Histopathological findings. Scoring system adapted from Hilgendorff and colleagues.28 British Journal of Anaesthesia  , DOI: ( /bja/aes297) Copyright © 2012 The Author(s) Terms and Conditions

3 Fig 2 Bland–Altman plot for repeated measurements for the assessment of agreement between TPUD CO (COtpud) and main pulmonary artery blood flow (COufp). The solid line represents the mean bias and the dotted lines represent LOA for all data (OI<10, OI 10–20, OI 20–40, and OI>40). British Journal of Anaesthesia  , DOI: ( /bja/aes297) Copyright © 2012 The Author(s) Terms and Conditions

4 Fig 3 Box and whisker plots for the median bias between CO measured by flow probe (COufp) and TPUD (COtpud) with increasing OI. The box represents the inter-quartile range of the bias: the whiskers express the 95% CI of the bias. Mixed effect linear model showed no significant difference between OI groups. British Journal of Anaesthesia  , DOI: ( /bja/aes297) Copyright © 2012 The Author(s) Terms and Conditions

5 Fig 4 Half circle polar plot representing the changes in CO measured with TPUD (COtpud) and the ultrasound flow probe around the main pulmonary artery (COufp). Central zone data (<10% changes) are excluded. The dashed line represents the mean radial bias (8°), dotted lines the 95% CI (32°). Almost all data are situated within the 30° radial limits. British Journal of Anaesthesia  , DOI: ( /bja/aes297) Copyright © 2012 The Author(s) Terms and Conditions

6 Fig 5 Examples of TPUD curves at baseline measurement (a) and after lung injury (B) of lamb 3. Notice the lower maximum, some increase in width, and an evident higher residual baseline. British Journal of Anaesthesia  , DOI: ( /bja/aes297) Copyright © 2012 The Author(s) Terms and Conditions

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