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Graduation Project I Device for controllable administration of drug dosage Prepared By: - Mona Ibrahim 200002091 - Azza Al Hassani 200002019 - Asma Ahmed.

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Presentation on theme: "Graduation Project I Device for controllable administration of drug dosage Prepared By: - Mona Ibrahim 200002091 - Azza Al Hassani 200002019 - Asma Ahmed."— Presentation transcript:

1 Graduation Project I Device for controllable administration of drug dosage Prepared By: - Mona Ibrahim Azza Al Hassani Asma Ahmed Hamda Al Ketbi Moza Al Shamsi Advisers name: - Dr. Yousef Haik

2 Presentation Layout Motivation Objectives Design Process Testing Device Dispensing Device Communication Device Conclusion

3 Motivation

4 Dispensing Device Testing Device Physician Patient Project Description

5 Blood Clotting A natural process in which blood cells and fibrin strands clump together to stop bleeding

6 Blood Coagulation Mechanism

7 Prothrombin Time (PT) The time it takes plasma to clot. PT is reported in seconds

8 International Normalization Ratio (inr) The ratio of the patient's clotting time to the mean reference value.

9 Anticoagulants Medications that delay the coagulation of blood Some of these are: Heparin Argatroban Hirudin Warfarin

10 the most widely used oral anticoagulant. It is a non-habit forming medication. to prevent formation of new blood clots in high-risk patients

11 Motivation Frequent Monitoring Dose adjustment Reduce patient error Time saving Availability of a patient medical history Reduce visitation to clinic.

12 Objectives Design a blood testing mechanism Design a drug dispensing mechanism Design and construct a working prototype of the system Dispensing Device Testing Device Physician Patient

13 Design Process Gantt Chart

14 The ProTime System-PT- INR Testing Market Analysis Coaguchek System INRatio®PT Monitoring System The Harmony INR Monitoring System

15 Function Structure Drug dose Blood sample System Global device function Overall function structure Blood Sample Testing Device Dispenser Communicator INR valueDose Drug Dosage Hold Sample

16 Specifications Dispensing DeviceMeasuring Device

17 Touch button operation Portable and easy to use Large, easy to read reporting screen Durable Repeatable Cost effective meter and test strip Dimension 5"×3" Touch button operation Portable and easy to use Large, easy to read reporting screen Durable Repeatable Cost effective meter and test strip Dimension 5"×3" Small sample volume: 20 µL Perform measurement automatically as soon as the sample is applied Measuring time is less than one minute Sensitive: can measure less than 1 mg/mL of Prothrombin Small sample volume: 20 µL Perform measurement automatically as soon as the sample is applied Measuring time is less than one minute Sensitive: can measure less than 1 mg/mL of Prothrombin Measuring Device Made of biocompatible materials Disposable sample holder Meet the International Biomedical Instrumentation standards Made of biocompatible materials Disposable sample holder Meet the International Biomedical Instrumentation standards

18 Store medicine Dispense one tablet at the time Time for dispensing to be less than 2 minutes Patient interference to the device is negligible Store medicine Dispense one tablet at the time Time for dispensing to be less than 2 minutes Patient interference to the device is negligible Cost effective Durable Dimension 5×2.5 Safe, no sharp corner Cost effective Durable Dimension 5×2.5 Safe, no sharp corner Dispensing Device

19 Cost effective Dimension 5×3 Communication between the medical doctor and the device within one day Cost effective Dimension 5×3 Communication between the medical doctor and the device within one day Communication Device The whole device dimension should not exceed 26.5"×12"

20 Developing concepts

21 Testing Morphological Chart Hold Sample Testing methods 1.RLC 2. Protein separation 3. Contact angle 4. Plasma profile 5. Viscosity 6. Light intensity 7. Shear stress 8.Charged Particle9.Elisa 10.Cantilever beam 11.Piezoelectri c 12. Blood layer thickness Display INR Digital display Printer LED monitor LCD

22 Testing Methods 1. RLC Testing Method

23 Experiments Measuring the capacitance across the copper plates with time

24 experiments Measuring the capacitance across the copper plates with time for different INR values (adding tissue factor)

25 Contact angle Method

26 Contact angle measurements camera sample stage light source Syringe Captive Bubble Contact Angle apparatus Result θ is too small to measure Measure surface area

27 Surface Area method

28 Protein Separation Method

29 viscosity Method Charged particle Method Resistance measurements

30 Measuring the distance moved Shear stress

31 Light intensity Blood layer thickness

32 Cantilever beam Method Plasma profile Method More

33 viscosity Method

34 Charged particle Method Function Generator +

35 Flow in pipes piezoelectric Method

36 Drug dispensing device

37 dispenser Morphological Chart Tablet Holder Mover Belt Shaft Gear Pulleys Manual Rollers Piston

38 dispenser Morphological Chart Actuator Dc motor pneumatichydraulic Step motor count IR sensor Laser Sensor Distance Sensor Lock solenoidWorm gearSpring damping Spring solenoid arm locking (hook)

39 dispenser Morphological Chart Cutter cutter Scissors (Sharp) Paper cutter Utility Knife Ejector

40 Dispensing concept 1

41 Dispensing concept 2

42 Dispensing concept 3

43 Dispensing concept 4

44 Dispensing concept 5

45 Communication device

46 communication Morphological Chart Sending signals Wire modem Sound Fiber optic Laser transmitter

47 Cost estimation

48 The budget

49 Testing device

50 Dispensing device

51 Communication part

52 Experimental part

53 CONCLUSION

54 FUTURE WORK Resuming investigating the testing methods Evaluating testing methods to select the proper one Analyzing the design of testing, dispensing, and communication Building a prototype for the whole device Experiments

55 Tasks

56 GANTT CHART


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