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1.Twist top casing to release top platform 2.Turn switch to on position 3.Wait 12 seconds for full injection 4.Turn switch to off position 5.Wait 4 minutes.

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Presentation on theme: "1.Twist top casing to release top platform 2.Turn switch to on position 3.Wait 12 seconds for full injection 4.Turn switch to off position 5.Wait 4 minutes."— Presentation transcript:

1 1.Twist top casing to release top platform 2.Turn switch to on position 3.Wait 12 seconds for full injection 4.Turn switch to off position 5.Wait 4 minutes for springs to cool 6.Reset springs by pulling top platform up into starting position 7.Twist top casing to lock platform in place Instructions for Use Concept Generation Validation Testing Metrics Path Forward West Pharmaceutical Services manufactures elastomer closures for injectable drug packaging and drug delivery system components for the pharmaceutical/biotech industry. We worked with Wests Innovation group for Delivery Systems to research a reusable drug delivery aid for home use. Existing West auto-injector products have all been designed to be disposable and are intended for only a single dose of medication. This method of injection, although effective, is not economical. West hopes to expand their product line to include a range of products that are reusable. This would reduce waste and overall cost. To research and develop a novel drive mechanism that can be reset and move a piston in a 1 mL syringe for dispensing of liquid. Acknowledgements 2013 Senior Design: West Pharmaceutical Services Novel Injectable Drug Delivery System Ryan OBoyle 1, Madison DeFrank 1, Derek Hunter 1, Kailey Nelson 2, Hayley Shaw 2, Biomedical 1 and Mechanical 2 Engineering, University of Delaware, Newark DE Background and Overview We would like to thank our sponsor, West Pharmaceutical Services, our advisor, Dr. Anita Singh, and the rest of the Senior Design Staff. Exploring the use of Nitinol springs of different compositions may optimize the force generated to administer 50 cP fluid. Research the use of ultra-capacitors in order to eliminate the need for a large battery. Coating the final prototype in a heat shielding material during manufacturing stages, to eliminate heat shielding tape. Downsizing the system to maximize compactness. Incorporate an automatic shut off system to increase safety and decrease spring fatigue. Inner Assembly Outer Assembly Bottom Platform Plunger Rod Top Platform Nitinol Springs Syringe Design Overview All internal 3D printed parts are lined with 2 layers of heat shielding tape. 8 Nitinol springs compress and return to original length when current is passed through. An 11.1 V battery pack passes 3.5A through each spring. The power source is wired to the springs and controlled by a high-amp toggle switch. A prefilled syringe can be inserted through the bottom platform and followed by a locking platform to secure it into place. When compressing, the springs supply up to 16.9 lb force to dispense the fluid. Syringe can be removed after injection, replaced with new syringe. The system can be reset to prepare for a new injection. Circuit Diagram 11.1 V battery pack wired to 4 Nitinol springs in series connected in parallel with 4 additional springs in series. The resistance in each spring was determined experimentally to be 850 mΩ. Testing of various viscous fluids in the mechanism determined the maximum viscosity achieved by the system. A completion reaches a constant displacement of 1.2 in. when a current of 6.1 A is passed. Scope FINAL CONCEPT: Shape Memory Alloy FINAL CONCEPT: Shape Memory Alloy Round 2 Neodymium Magnets Chemical Reaction Coil Wire/ Electromagnetic Force Round 2 Neodymium Magnets Chemical Reaction Coil Wire/ Electromagnetic Force Round 1 Shape Memory Alloy Soft Metal Alloy Flat Coil Spring Motor Driven Hydraulic Component Round 1 Shape Memory Alloy Soft Metal Alloy Flat Coil Spring Motor Driven Hydraulic Component External Casing Locking Platform Top Casing Inner Assembly , 4 Full Assembly Performing failure testing upon the prototype determined a recommended number of uses and an allotted amount of time to reset the device, for fluids of varying viscosity.


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