1. Bortezomib sensitivity correlates with basal NF-κB activity in KP lung adenocarcinoma cell lines.
Bortezomib sensitivity correlates with basal NF-κB activity in KP lung adenocarcinoma cell lines. A, relative cell viability in cell lines treated with increasing doses of bortezomib for 24 hours. 3TZ, diamond; LKR13, triangle; KP, solid lines; KPM, dashed lines. Error bars are SD (n = 3). B, lung cancer cell lines with high basal NF-κB activity were sensitive to bortezomib. NF-κB p65 DNA-binding activity was determined by ELISA from nuclear extracts of KP cell lines and LKR13 cells (set as 1). Relative viability was measured after 5 nM bortezomib treatment, as in A.
Wen Xue et al. Cancer Discovery 2011;1:
©2011 by American Association for Cancer Research