1. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. FETTE ABSOLUT Filter system For production processes in chemical and pharmaceutical industries

2. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. Reason for development of new containment technologies The rise of the usage of potent compounds within the pharma industry worldwide The awareness of the dangers created by cross contamination and personnel safety The general industrial dust filters applied in the pharmaceutical industry today Result: Creating the missing link to meet the latest requirements in hygienic pharmaceutical production processes

3. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. Disassembly Conventional HEPA filter units manufactured for the nuclear industry Highest possible requirements in regard to: Efficiencies Containment Origin of the new filter system for production lines For manual handling of hazardous products in chemical and pharmaceutical industry

4. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. Laminar Flow Ceilings Personnel Floodgate FETTE Absolut fields of production Dust Filtration Glove- Boxes Isolators Gasab- sobtion Ventilation

5. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. Product overview

6. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. Dust filtration and recovery of high dust loads from production machines such as: Fluid bed dryers Tablet presses Capsule filling machines Tablet coaters Tablet filling machines etc. Application of the new filter system

7. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. General survey GMP series for production rooms Single module unit Application : Dust recovery from tablet presses Features: 2 stage HEPA filter unit Integrated glove box Scanning device

8. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. GMP series for production rooms Multiple module unit Application : Dust recovery from tablet presses Features: 2 stage HEPA filter unit Integrated glove box Tablet for filter stage General survey

9. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. Standard series for machine rooms Single module unit Application : Dust recovery from tablet presses Features: 2 stage HEPA filter unit Reinforced body for application in explosion areas General survey

10. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. DOP Measuring of efficiency Typical Laser- Particle Counter

11. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. Take away the servicing door Filter Change Pull out the inner plastic bag, which is always part of the unit Lower the sealed filter cassette for take out 12 3

12. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. Pull the cassette out into the existing plastic bag Filter Change Heat sealing of the cassette twice to cut the bag in between In the end the used and sealed filter cassette is ready for disposal 4 56

13. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. The Operator pulls the can to the front, in order to seal it, inside the isolator Dust recovery He puts a lid onto the inner plastic bag 12

14. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. The operator puts the can to the side in order to pull the closed inner bag out Dust recovery 3 4 As a further step he pulls the inner bag out through a LaCalhene valve into the outer bag

15. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. The door is closed from inside to be able to undock the alpha port (outer port) Dust recovery The outer alpha port is being undocked by turning The double sealed product now is ready for take away in a safest possible way 567

16. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. Weighing of recovered product The operator, according to the efficiency measurement of the cassettes, gets a printout for documentation of the recovered product

17. © All rights reserved by Fette GmbH, also in case of pending patens. All uses, e.g. like copying or disclosure to third parties, strictly restricted to us. Targets Our targets are to close the gap in hygienic pharmaceutical production processes by providing: Lowest possible OELs Highest possible filter efficiencies