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Matrix metalloproteinase 2 is suppressed by trapidil, a CD40–CD40 ligand pathway inhibitor, in human abdominal aortic aneurysm wall  Hirotaka Nagashima,

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Presentation on theme: "Matrix metalloproteinase 2 is suppressed by trapidil, a CD40–CD40 ligand pathway inhibitor, in human abdominal aortic aneurysm wall  Hirotaka Nagashima,"— Presentation transcript:

1 Matrix metalloproteinase 2 is suppressed by trapidil, a CD40–CD40 ligand pathway inhibitor, in human abdominal aortic aneurysm wall  Hirotaka Nagashima, MD, PhD, Yoshikazu Aoka, MD, Yasunari Sakomura, MD, PhD, Kenta Uto, MD, Akiko Sakuta, MD, Shigeyuki Aomi, MD, PhD, Hiromi Kurosawa, MD, PhD, Nobuhisa Hagiwara, MD, PhD, Masatoshi Kawana, MD, PhD, Hiroshi Kasanuki, MD, PhD  Journal of Vascular Surgery  Volume 39, Issue 2, Pages (February 2004) DOI: /j.jvs

2 Fig 1 Trapidil significantly reduced the levels of active MMP-2 in a concentration-dependent manner in organ cultures (A) but did not alter that of MMP-9 (B). Value of the trend test, P < .001. Journal of Vascular Surgery  , DOI: ( /j.jvs )

3 Fig 2 Effect of trapidil (10 μmol/L), anti-CD154 (100 μmol/L), or aspirin (10 μmol/L) on active MMP-2 production in AAA tissues. Both trapidil and anti-CD154 antibody inhibited MMP-2 production. *P < .01 vs lane 1. Journal of Vascular Surgery  , DOI: ( /j.jvs )

4 Fig 3 Representative pattern of semiquantitative RT-PCR for MMP-2 and MMP-9. Trapidil suppressed MMP-2 mRNA expression but not MMP-9 mRNA expression. Journal of Vascular Surgery  , DOI: ( /j.jvs )

5 Fig 4 Immunohistochemical analysis. A, Hematoxylin and eosin staining. AAA tissue contains numerous inflammatory cells (magnification, 40×). B, MMP-2 is positive on macrophages (magnification, 400×). C and D, MMP-9 is produced by macrophages, a lot of neutrophils circulating in blood vessels, or neutrophils infiltrating into the aortic wall tissue (magnification, 400×). Journal of Vascular Surgery  , DOI: ( /j.jvs )

6 Fig 5 Immunostaining for CD40. A, Low magnification (40×). B, High magnification (400×). CD40 was expressed on B cells, T cells, and macrophages. Neutrophils did not express CD40. Journal of Vascular Surgery  , DOI: ( /j.jvs )

7 Fig 6 Schematic hypothesis for the inhibitory effect of trapidil on AAA formation and progression. Journal of Vascular Surgery  , DOI: ( /j.jvs )

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