Presentation is loading. Please wait.

Presentation is loading. Please wait.

Figure 5 The role of Ly6Chi and Ly6Clo monocytes

Published byPhebe Alexander Modified over 5 years ago

Similar presentations

Presentation on theme: "Figure 5 The role of Ly6Chi and Ly6Clo monocytes"— Presentation transcript:

1 Figure 5 The role of Ly6Chi and Ly6Clo monocytes
in the development of different mouse models of arthritis Figure 5 | The role of Ly6Chi and Ly6Clo monocytes in the development of different mouse models of arthritis. a | Ly6Clo monocytes drive the development of sterile inflammatory arthritis. Transfer of serum from K/B × N mice causes a CCR2-independent influx of Ly6Clo monocytes, which give rise to MHCII+ inflammatory macrophages. These polarize towards an alternatively activated phenotype (MHCII−) during the development of arthritis. Tissue-resident synovial macrophages (largely MHCII−) limit the development of arthritis. b | Ly6Chi monocytes drive the development of antigen-induced inflammatory arthritis. Methylated bovine serum albumin (mBSA) challenge causes a CCR2-dependent influx of Ly6Chi monocytes, which in turn leads to an increase in inflammatory MHCII+ macrophage numbers. Proportions of anti-inflammatory CD206+ macrophages are decreased in inflamed knees compared with control knees treated with phosphate-buffered saline (PBS). Ly6C, lymphocyte antigen 6C2. Udalova, I. A. et al. (2016) Macrophage heterogeneity in the context of rheumatoid arthritis Nat. Rev. Rheumatol. doi: /nrrheum

Download ppt "Figure 5 The role of Ly6Chi and Ly6Clo monocytes"

Similar presentations

Figure 1 Lymphocytes during the disease

Figure 1 Lymphocytes during the disease
of different experimental arthritis models

of different experimental arthritis models
Figure 3 Example of how a noncoding regulatory rheumatoid

Figure 3 Example of how a noncoding regulatory rheumatoid
Figure 1 Historical evolution of the clinical classification and

Figure 1 Historical evolution of the clinical classification and
Figure 2 Representative MSI data obtained from human joints

Figure 2 Representative MSI data obtained from human joints
Figure 1 Rheumatoid arthritis development over time in relation to the level of inflammation Figure 1 | Rheumatoid arthritis development over time in relation.

Figure 1 Rheumatoid arthritis development over time in relation to the level of inflammation Figure 1 | Rheumatoid arthritis development over time in relation.
Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Rheumatol. doi: /nrrheum
Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Rheumatol. doi: /nrrheum
Figure 1 Enthesitis versus synovitis

Figure 1 Enthesitis versus synovitis
Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Rheumatol. doi: /nrrheum
Figure 1 Factors underlying metabolic alterations in osteoarthritis

Figure 1 Factors underlying metabolic alterations in osteoarthritis
Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Rheumatol. doi: /nrrheum
Figure 4 Simplified T cell and antigen presenting

Figure 4 Simplified T cell and antigen presenting
Critical Role for Skin-Derived Migratory DCs and Langerhans Cells in TFH and GC Responses after Intradermal Immunization  Clément Levin, Olivia Bonduelle,

Critical Role for Skin-Derived Migratory DCs and Langerhans Cells in TFH and GC Responses after Intradermal Immunization  Clément Levin, Olivia Bonduelle,
Figure 4 Ex vivo synovial tissue culture viability

Figure 4 Ex vivo synovial tissue culture viability
A functional folate receptor is induced during macrophage activation and can be used to target drugs to activated macrophages by Wei Xia, Andrew R. Hilgenbrink,

A functional folate receptor is induced during macrophage activation and can be used to target drugs to activated macrophages by Wei Xia, Andrew R. Hilgenbrink,
Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Rheumatol. doi: /nrrheum
The GR dimer in stromal cells mediates the induction of genes of anti-inflammatory macrophages after DEX treatment in serum transfer-induced arthritis.

The GR dimer in stromal cells mediates the induction of genes of anti-inflammatory macrophages after DEX treatment in serum transfer-induced arthritis.
Figure 2 Main functions of IL-1

Figure 2 Main functions of IL-1
Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Rheumatol. doi: /nrrheum

Similar presentations

Ads by Google