1. Jim Matthews Arizona Biomedical Research Commission Jungdae Kokotov 5AM Solutions July 27, 2010 www.5amsolutions.com

2. Webinar Technical Details Type questions in advance; click sendQuestions + answers appear in chat window During discussion time, raise hand to speak

3. The Issue of Tissue Biospecimens are at the core of discovery-oriented scientific research. Issues: Collecting Annotating Finding Obtaining

4. About ABRC Funding Proceeds from the Sale of Tobacco Products Funding Arizona Lottery Arizona Biomedical Research Commission Research Program Arizona Translational Resource Network (AzTransNet)

5. What Led Us Here Difficulty in finding tissue for research The Tissue Issue January 2007 Anna Barker January 2007

6. Our Process RFPResponsesSelection CriteriaDeciding Factors5AM Solutions The Solicitation

7. Our Vision Sun Health Research Institute

8. Arizona Biospecimen Consortium Governance Committee Business Model Commitments Governance Model Regulatory Compliance Agreements Standards Committee Standardized Collection Procedures Minimum Data Set Federal Standards Tissue Types/ Informed Consent Quality Control A Consortium of Institutional Partners

9. Our Challenges Partnership buy-in Synchronicity of technology + governance

10. From Vision to Working System Agile processes Engaged stakeholders 5AM participation in Consortium meetings

11. Biolocator: High Level Workflow 11

12. How We Integrate – and Share – the Data ABL Commercial BioBanking Solution Custom Application CBM – NCIs caGrid Automatic data pullPeriodic data import

13. Share Information Over NCIs caGrid http://portal.training.cagrid.org/web/guest/home

14. Our Technical Challenges Mapping data Fields Diverse systems, diverse data fields How do we find a common model…? NCIs Common Biorepository Model Values Diverse systems, diverse data values How do we find a common disease vocabulary…? SNOMED-CT Collection Date Quality Rating Specimen Type Tumor Rating Disease Type Liquid Nitrogen Paraffin Block Collection Date Quality Rating Specimen Type Tumor Rating Disease Type Liquid Nitrogen Paraffin Block Date Time Tissue Type Cancer Boolean Lab Report Freetext Date Time Tissue Type Cancer Boolean Lab Report Freetext Malignant Tumor of Breast Breast Carcinoma 254837009 Breast Cancer Breast Cancer Type 1 Susceptibility Protein

15. https://demo.5amsolutions.com/tissuelocator-web/

16. ABRCs Future Role in the Arizona Biomedical Consortium Funding the ABL program Demonstrating usefulness Assisting institutional partners Equipment Personnel Integration Support

17. Next Steps for the Arizona Biospecimen Consortium Develop a Platform for Future Services Cord blood bank Cord blood patient registry Trauma center data warehouse linkage Expand our Partners + Participants Phoenix Indian Medical Center Phoenix VA Others

18. Contact Us James Matthews Deputy Director Arizona Biomedical Resource Commission james.matthews@azabrc.gov Jungdae Kokotov Project Manager Biolocator 5AM Solutions jkokotov@5amsolutions.com Arizona Biospecimen Locator Demo: https://demo.5amsolutions.com/tissuelocator-web/

19. ??? What else would you like to discuss – open discussion of your questions, topics, concerns