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Fig. 1. [11C]Martinostat images of all subjects show high cortical binding and distinct gray-white matter differences. [11C]Martinostat images of all subjects.

Published byKonrad Wojciechowski Modified over 5 years ago

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Presentation on theme: "Fig. 1. [11C]Martinostat images of all subjects show high cortical binding and distinct gray-white matter differences. [11C]Martinostat images of all subjects."— Presentation transcript:

1 Fig. 1. [11C]Martinostat images of all subjects show high cortical binding and distinct gray-white matter differences. [11C]Martinostat images of all subjects show high cortical binding and distinct gray-white matter differences. (A) [11C]Martinostat (injected dose, 4.7 mCi; specific activity, 1.1 mCi/nmol) images averaged from 60 to 90 min after radiotracer injection (SUV60-90 min; SUV = radioactivity per injected dose per body weight) from a representative subject overlaid on anatomical magnetic resonance (MR) image. (B) [11C]Martinostat SUVR60-90 min images of individual subjects. To facilitate intersubject comparison of regional HDAC distribution, we normalized regional SUV60-90 min to an individual subject’s white matter SUV60-90 min as SUV60-90 min ratios (SUVR60-90 min). The SUVR60-90 min images were also coregistered with an MNI152 standard human atlas brain. Hsiao-Ying Wey et al., Sci Transl Med 2016;8:351ra106 Published by AAAS

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