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Indoxyl Sulfate and p-Cresyl Sulfate in Chronic Kidney Disease

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Presentation on theme: "Indoxyl Sulfate and p-Cresyl Sulfate in Chronic Kidney Disease"— Presentation transcript:

1 Indoxyl Sulfate and p-Cresyl Sulfate in Chronic Kidney Disease
Indoxyl Sulfate and p-Cresyl Sulfate in Chronic Kidney Disease. Could These Toxins Modulate the Antioxidant Nrf2-Keap1 Pathway?  Milena Barcza Stockler-Pinto, PhD, Denis Fouque, PhD, Christophe O. Soulage, PhD, Marine Croze, PhD, Denise Mafra, PhD  Journal of Renal Nutrition  Volume 24, Issue 5, Pages (September 2014) DOI: /j.jrn Copyright © 2014 National Kidney Foundation, Inc. Terms and Conditions

2 Figure 1 Nuclear factor (erythroid-2-related factor)-2 levels from hemodialysis patients and healthy individuals (P < .005). Journal of Renal Nutrition  , DOI: ( /j.jrn ) Copyright © 2014 National Kidney Foundation, Inc. Terms and Conditions

3 Figure 2 Putative mechanism of Nrf2 and protein-bound uremic toxins. AREs, antioxidant response elements; Keap1, Kelch-like ECH associating protein-1; NF-κB, nuclear factor-κB; Nrf2, nuclear factor (erythroid-2-related factor)-2; OAT, organic anion transporter; ROS, reactive oxygen species. Journal of Renal Nutrition  , DOI: ( /j.jrn ) Copyright © 2014 National Kidney Foundation, Inc. Terms and Conditions


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