1. Figure 1 Diagnostic tiers of Parkinson disease as single disease
Figure 1 | Diagnostic tiers of Parkinson disease as single disease. In this conceptual scheme proposed for research diagnostic criteria5, three separate a | clinical, b | pathological, and c | genetic–molecular tiers are layered according to high (inner circles) or low (outer circles) likelihood of their convergence to a single Parkinson disease (PD) construct. d | A perfect model of PD, according to the tiered cores, would encompass the clinically established MDS criteria for PD, demonstration of α-synuclein pathology, and a PD-causing gene mutation.
Espay, A. J. et al. (2017) Precision medicine for disease modification in Parkinson disease
Nat. Rev. Neurol. doi: /nrneurol