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Figure 2 Three distinct mechanisms of activation of

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1 Figure 2 Three distinct mechanisms of activation of
the epidermal growth factor receptor (EGFR) pathway Figure 2 | Three distinct mechanisms of activation of the epidermal growth factor receptor (EGFR) pathway. a | Ligand binding. Soluble ErbB ligands can bind and thereby activate their ErbB receptor (here EGFR) in an endocrine (distant cell), paracrine (neighbouring cell), or autocrine (same cell) way. b | Membrane-anchored ligands can activate ErbB receptors (here EGFR) present on membranes of adjacent cells (juxtacrine signalling). c | Transactivation of EGFR by G-protein coupled receptors (GPCRs). Of note, the cytoplasmic tail of the ligand is depicted in panels a and c. Harskamp, L. R. et al. (2016) The epidermal growth factor receptor pathway in chronic kidney diseases Nat. Rev. Nephrol. doi: /nrneph


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