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Chris Healey, MD, Patrick Forgione, MD, Karen M

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Presentation on theme: "Chris Healey, MD, Patrick Forgione, MD, Karen M"— Presentation transcript:

1 A new in vitro model of venous hypertension: the effect of pressure on dermal fibroblasts 
Chris Healey, MD, Patrick Forgione, MD, Karen M. Lounsbury, PhD, Kim Corrow, AAS, Turner Osler, MD, Michael A. Ricci, MD, Andrew Stanley, MD  Journal of Vascular Surgery  Volume 38, Issue 5, Pages (November 2003) DOI: /S (03)

2 Fig 2 Digital images of dermal fibroblasts grown for 10 days under conditions of atmospheric pressure (ATM) and 120 mm Hg above ATM (ATM + 120). Images at 2500× magnification. Journal of Vascular Surgery  , DOI: ( /S (03) )

3 Fig 3 Cell growth at atmospheric pressure (ATM) and elevated pressures (ATM + 60 and ATM + 120). Journal of Vascular Surgery  , DOI: ( /S (03) )

4 Fig 4 Immunohistochemistry stains of (A) cells grown for 10 days at atmospheric pressure (ATM) and (B) cells grown for 10 days at 120 mmHg above ATM. Red coloration of cytoplasm represents fibronectin immunostaining (mouse anti-human fibronectin monoclonal ab followed by fluorescein conjugated goat anti-mouse IgG polyclonal ab. Green color represents YoYo RNAse stain of nuclei. Confocal microscopy was used for imaging. Journal of Vascular Surgery  , DOI: ( /S (03) )

5 Fig 5 Percentage of cell population staining positive for fibronectin of ATM, ATM + 60, and ATM Journal of Vascular Surgery  , DOI: ( /S (03) )

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