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Treatment of Stage I and II Non-small Cell Lung Cancer

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Presentation on theme: "Treatment of Stage I and II Non-small Cell Lung Cancer"— Presentation transcript:

1 Treatment of Stage I and II Non-small Cell Lung Cancer
John A. Howington, MD, FCCP, Matthew G. Blum, MD, FCCP, Andrew C. Chang, MD, FCCP, Alex A. Balekian, MD, MSHS, Sudish C. Murthy, MD, PhD, FCCP  CHEST  Volume 143, Issue 5, Pages e278S-e313S (May 2013) DOI: /chest Copyright © 2013 The American College of Chest Physicians Terms and Conditions

2 Figure 1 Outcomes of surgical resection for lung cancer according to specialization. CHEST  , e278S-e313SDOI: ( /chest ) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

3 Figure 2 Outcomes of surgical resection for lung cancer according to case volume. CHEST  , e278S-e313SDOI: ( /chest ) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

4 Figure 3 [Section 2.2.2] Meta-analysis of relationship between outcomes and hospital case volume of lung cancer resections. A, Perioperative mortality. B, Long-term survival. Higher Limit = lowest annual volume in the high-volume category; lower limit = highest annual volume in the lower limit category. (Reproduced with permission from von Meyenfeldt et al.12) CHEST  , e278S-e313SDOI: ( /chest ) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

5 Figure 4 Outcomes of surgical resection for lung cancer according to teaching facility status. CHEST  , e278S-e313SDOI: ( /chest ) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

6 Figure 5 [Section 3.1] Outcomes of thoracoscopic vs open lung cancer resection. Results of a meta-analysis of comparative studies. Most of the included studies were cohort studies, not randomized studies. A, Perioperative outcomes. B. Long-term outcomes. Card = cardiac; Compl = complication; F/U = follow-up; Hosp LOS = hospital length of stay; Periop = perioperative; Pulm = pulmonary; rand = randomized studies; Resp dysfctn = respiratory dysfunction; S at max f/u = survival at maximal follow-up; Surv = survival; VATS = video-assisted thoracic surgery. (Data from Cheng et al.50 Figures reproduced with permission from Detterbeck.51) CHEST  , e278S-e313SDOI: ( /chest ) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

7 Figure 6 Comparative outcomes for lobectomy and sublobar resection.
CHEST  , e278S-e313SDOI: ( /chest ) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

8 Figure 7 Comparative outcomes for wedge resection and segmentectomy.
CHEST  , e278S-e313SDOI: ( /chest ) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

9 Figure 8 Primary tumor control and survival following SBRT for clinical stage I NSCLC. CHEST  , e278S-e313SDOI: ( /chest ) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

10 Figure 9 Primary tumor control and survival following RFA for clinical stage I NSCLC. CHEST  , e278S-e313SDOI: ( /chest ) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

11 Figure 10 Outcomes of adjuvant chemotherapy after surgical resection.
CHEST  , e278S-e313SDOI: ( /chest ) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

12 Figure 11 [Section 6.1.2] Meta-analysis of effect of postoperative chemotherapy on overall survival. A, Effect of traditional cytotoxic chemotherapy. B, Effect of uracil/tegafur chemotherapy. Exploratory analyses of the effect of surgery and chemotherapy vs surgery alone on survival, by use of tegafur plus uracil or tegafur, and by stage and performance status. Overall survival: hazard ratio of death with postoperative chemotherapy vs control (no chemotherapy) by treatment strategy or baseline patient characteristic. PS = performance status. (Reproduced with permission from Pignon et al184 and Arriagada et al.200) CHEST  , e278S-e313SDOI: ( /chest ) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

13 Figure 12 [Section 6.2.1] Meta-analysis of postoperative radiotherapy on overall survival. (Reproduced with permission from Burdett et al.214) CHEST  , e278S-e313SDOI: ( /chest ) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

14 Figure 13 Outcomes of adjuvant radiotherapy after surgical resection.
CHEST  , e278S-e313SDOI: ( /chest ) Copyright © 2013 The American College of Chest Physicians Terms and Conditions


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