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Dose responsive suppression of myointimal hyperplasia by dexamethasone

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Presentation on theme: "Dose responsive suppression of myointimal hyperplasia by dexamethasone"— Presentation transcript:

1 Dose responsive suppression of myointimal hyperplasia by dexamethasone
Michael D. Colburn, MD, Wesley S. Moore, MD, Hugh A. Gelabert, MD, William J. Quiñones-Baldrich, MD  Journal of Vascular Surgery  Volume 15, Issue 3, Pages (March 1992) DOI: / (92)90190-J Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

2 Fig. 1 Chart shows effect of graded doses of dexamethasone on IH/IEL index. Journal of Vascular Surgery  , DOI: ( / (92)90190-J) Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

3 Fig. 2 Chart shows effect of graded doses of dexamethasone on measured blood flow. Journal of Vascular Surgery  , DOI: ( / (92)90190-J) Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

4 Fig. 3 Chart shows effect of graded doses of dexamethasone on calculated value ΔP/flow. Journal of Vascular Surgery  , DOI: ( / (92)90190-J) Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

5 Fig. 4 Photomicrograph of control artery shows high degree of intimal hyperplasia (Verhoeff van Geison's stain; original magnification × 20). Journal of Vascular Surgery  , DOI: ( / (92)90190-J) Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

6 Fig. 5 Photomicrograph of artery treated for 8 weeks with dexamethasone mg/kg shows some reduction in degree of intimal hyperplasia (Verhoeff van Geison's stain; original magnification × 20). Journal of Vascular Surgery  , DOI: ( / (92)90190-J) Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

7 Fig. 6 Absence of significant intimal hyperplasia in photomicrograph of artery treated for 8 weeks with dexamethasone mg/kg (Verhoeff van Geison's stain; original magnification × 20). Journal of Vascular Surgery  , DOI: ( / (92)90190-J) Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions


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