1. Treatment of Glioma in the 21st Century: An Exciting Decade of Postsurgical Treatment Advances in the Molecular Era 
Joon H. Uhm, MD, Alyx B. Porter, MD 
Mayo Clinic Proceedings 
Volume 92, Issue 6, Pages (June 2017)
DOI: /j.mayocp
Copyright © 2017 Mayo Foundation for Medical Education and Research Terms and Conditions

2. Figure 1
Signal transduction pathways in glioma. AKT = protein kinase B or serine/threonine kinase; mTOR = mechanistic target of rapamycin; PKC = protein kinase C; PTEN = phosphatase and tensin homolog; p53 = tumor protein 53; TF = transcription factor; VEGF = vascular endothelial growth factor. ∗ Indicates targets for chemotherapy.
Mayo Clinic Proceedings  , DOI: ( /j.mayocp )
Copyright © 2017 Mayo Foundation for Medical Education and Research Terms and Conditions

3. Figure 2
Therapeutic challenges and potential solutions presented by immunologically based therapies. A = tumor mass; B = tumor antigens are processed by the dendritic cells, which present the antigens to T cells, thereby converting naive T cells to their activated forms; C = activated T cells are capable of entering the central nervous system via expression of specific cell surface molecules; D = tumor microenvironment; EGFR = epidermal growth factor receptor; red triangles = blood-brain barrier.
Mayo Clinic Proceedings  , DOI: ( /j.mayocp )
Copyright © 2017 Mayo Foundation for Medical Education and Research Terms and Conditions